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UrduPolygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person’s risk of developing certain diseases, such as coronary artery disease (CAD). By analyzing a person’s DNA, PRSs offer insights into an individual’s genetic predisposition for conditions like heart disease, potentially informing a more personalized approach to healthcare. But there can be significant variability across currently available PRSs, which may limit their reliability for individual predictions, according to new research from the Perelman School of Medicine at the University of Pennsylvania published this week in JAMA and presented at the American Heart Association’s Scientific Sessions in Chicago.
Tag: Coronary Artery Disease
Hackensack Meridian Mountainside Medical Center Cardiac Catheterization Laboratory Adopts Cathworks Technology
Hackensack Meridian Mountainside Medical Center’s Cardiac Catheterization Laboratory is proud to announce the integration of the Cathworks FFRangio® System, a cutting-edge non-invasive tool that enhances decision-making during coronary interventions. This advanced technology reaffirms the lab’s commitment to providing world-class care to patients with coronary artery disease.
ESC Congress 2024: Smidt Heart Institute Experts Available to Comment
Cardiac physicians and investigators from the Smidt Heart Institute at Cedars-Sinai will share new research and clinical insights at the European Society of Cardiology Congress in London Aug. 30 through Sept. 2.
CRF Announces TCT 2024 Late-Breaking Clinical Trials and Science
The Cardiovascular Research Foundation (CRF) is pleased to announce the late-breaking clinical trials and science to be featured at TCT 2024.
Hackensack Meridian Jersey Shore University Medical Center Providing Patients the First Revisional, In-Stent Heart Treatment
Heart care experts at Hackensack Meridian Jersey Shore University Medical Center are now providing patients with the AGENTTM Drug-Coated Balloon (DCB), designed to treat coronary in-stent restenosis (ISR) in patients with coronary artery disease.
New AI Tool Finds Rare Variants Linked to Heart Disease in 17 Genes
Using an advanced artificial intelligence tool, researchers at the Icahn School of Medicine at Mount Sinai have identified rare coding variants in 17 genes that shed light on the molecular basis of coronary artery disease (CAD), the leading cause of morbidity and mortality worldwide. The discoveries, detailed in the June 11 online issue of Nature Genetics, reveal genetic factors impacting heart disease that open new avenues for targeted treatments and personalized approaches to cardiovascular care. The investigators used an in silico, or computer-derived, score for coronary artery disease (ISCAD) that holistically represents CAD, as described in a previous paper by the team in The Lancet. The ISCAD score incorporates hundreds of different clinical features from the electronic health record, including vital signs, laboratory test results, medications, symptoms, and diagnoses. To build the score, they trained machine learning models on the electronic health records of 604,914 individuals
Passive heat exposure increases stress on the heart, posing risk to adults with history of CAD
A laboratory controlled experiment including both healthy adults and adults with coronary artery disease (CAD) found that passive heat exposure was enough to increase myocardial blood flow (MBF) in all participants, regardless of age and health status, creating significant stress on the heart.
Mount Sinai Experts to Present New Research on Long COVID, Lung Cancer, Asthma, Sleep Apnea, and More at ATS 2024 International Conference
Available for interview on breaking news, trending topics in respiratory medicine
BIDMC-led trial leads to FDA approval of coronary drug-coated balloons
In the largest randomized clinical trial and first of its kind to date in the United States, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) assessed the efficacy and safety of using a drug-coated balloon in patients undergoing coronary angioplasty.
8 Key Facts About Statins and Cholesterol
Statins can help lower cholesterol and reduce the risk of heart attacks, stroke and other heart and vascular problems. But they aren’t right for all patients, and they can rarely cause side effects. Cardiologist Melissa Tracy answers patients’ most frequently asked questions about statins.
Intravascular Imaging Significantly Improves Survival, Safety, and Outcomes in Cardiovascular Stenting Procedures Over Conventional Angiography
Results from this large-scale synthesis of all prior clinical trials could increase usage of several types of high-resolution imaging for guiding interventional coronary procedures
Cardiac Arrest: Hispanics, Latinos With Kidney Disease at High Risk
Hispanics and Latinos with chronic kidney disease are at significant risk for suffering from sudden cardiac arrest, according to a new study from the Smidt Heart Institute at Cedars-Sinai.
New Study Confirms HeartFlow FFRCT Leads to Improved Patient Outcomes
A diagnostic test, first offered in the United States at University Hospitals Harrington Heart & Vascular Institute, has now shown through a clinical study to significantly decrease cardiovascular mortality, reduce additional non-invasive heart testing, and increase cath lab efficiency.
Researchers uncover how a genetic mutation can cause individuals with normal cholesterol levels to develop coronary artery disease at a young age
A novel molecular pathway to explain how a mutation in the gene ACTA2 can cause individuals in their 30s – with normal cholesterol levels and no other risk factors — to develop coronary artery disease has been identified, according to researchers with UTHealth Houston.
Coronary Bioresorbable Scaffolds Nearly as Safe and Effective as Conventional Metal Stents for Heart Disease Patients
First-generation bioresorbable vascular scaffolds (BVS) may be just as effective as drug-eluting metallic stents, which are currently the standard treatment for heart disease patients undergoing percutaneous coronary intervention (PCI).
Hackensack Meridian Mountainside Medical Center Receives the HeartFlow® CT Quality Award for Commitment to Patients’ Heart Health
Mountainside received the HeartFlow® CT Quality Award. Honorees are in the top 22% of medical centers providing patients with better pathways for identifying and understanding heart health using CT scans and HeartFlow® Analysis, a groundbreaking technology for diagnosing coronary artery disease.
Digital Marker for Coronary Artery Disease Built by Researchers at Mount Sinai
Using machine learning and clinical data from electronic health records, researchers at the Icahn School of Medicine at Mount Sinai in New York constructed an in silico, or computer-derived, marker for coronary artery disease (CAD) to better measure clinically important characterizations of the disease.
Chest Pain Patients Benefit from Precision Diagnostic Testing Approach
A study comparing two approaches for diagnosing heart disease found that a risk analysis strategy is superior to the usual approach of immediately performing functional tests or catheterization for low- to intermediate-risk patients with new-onset chest pain.
Symptoms, quality of life important to guide treatment for peripheral artery disease (PAD)
For the approximately 8.5 million people in the U.S. living with peripheral artery disease (PAD – pronounced P-A-D), which is narrowed or clogged arteries in the legs, treatment decisions and criteria for success should be led by their symptoms and self-reported quality of life, according to a new American Heart Association scientific statement published today in the Association’s flagship, peer-reviewed journal Circulation.
Nordic Walking Improves Functional Capacity in People with Heart Disease
Researchers identified a greater increase in functional capacity, the ability to perform activities of daily living, as a result of Nordic walking in patients with coronary heart disease compared to standard high-intensity interval training and moderate-to-vigorous intensity continuous training.
Revealing the individual immune cells inside the plaque that causes life-threatening heart attacks
Through single-cell RNA sequencing, a research group has successfully illuminated the characteristics of Myeloid immune cells in coronary plaque, which causes acute coronary syndrome (this term includes conditions such as unstable angina and acute myocardial infarction (heart attack)). Based on this data, they hope to develop a treatment method that can stabilize coronary plaque.
Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease
Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…
New Treatment Approach for Advanced Coronary Artery Disease Leads to Improved Outcomes
Study outlines better way to identify where stents are necessary
Novel Lithotripsy Technology to Treat Coronary Blockages
For Joseph Komor, what started out as six months of neck pain, wound up in a lifesaving procedure to treat his coronary artery disease using advanced sonic wave technology.
Game-Changing Tool for Preventing Heart Attacks
The Valley Hospital, in Ridgewood, NJ, is among the first to use non-invasive, artificial intelligence imaging technology to prevent heart attacks by characterizing unstable plaque buildup with a high potential to rupture that can lead to a heart attack.
Mother and son receive the same lifesaving procedure by the same surgeon
In an odd twist of fate, 57-year-old Burnett Langley discovered after his four-vessel coronary artery bypass that his surgeon, Steven Eisenberg, MD, performed the same procedure on his mother, Monnie, exactly 10 years earlier.
Media Registration for TCT 2021 Now Open
Media registration is now open for TCT 2021 (Transcatheter Cardiovascular Therapeutics), the annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT will be held November 4-6, 2021 in Orlando, Florida at the Orange County Convention Center and simultaneously broadcast live.
Stair climbing offers significant cardiovascular and muscular benefits for heart patients, researchers find
A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits.
Scientists find genetic link to clogged arteries
High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.
Genetic testing proves beneficial in prescribing effective blood thinners
A new research paper funded in part by the National Heart, Lung and Blood Institute (NHLBI) shows a clear advantage of genetic testing in helping health care providers choose the appropriate anti-platelet drug. Testing helps determine if a patient carries genetic variants in CYP2C19 that cause loss of its function. These variants interfere with the body’s ability to metabolize and activate clopidogrel, an anti-platelet medication.
New Non-Invasive Cardiac Test Can Help Physicians Diagnose Heart Disease
MedStar Washington Hospital Center became first in Washington, D.C. and central Maryland to adopt the HeartFlow® Analysis, a first-of-its-kind non-invasive technology to help physicians diagnosis heart disease and determine the next steps in treatment for each patient.
TCT Connect Agenda Now Available
The TCT Connect agenda is now available online. TCT, the annual scientific symposium of CRF and the world’s premier educational meeting specializing in interventional cardiovascular medicine, will take place online October 14-18. Every year, TCT features major medical research breakthroughs and gathers leading researchers and clinicians from around the globe to present and discuss the latest evidence-based research in the field.
Announcing the TCT Connect Late-Breaking Trials and Science
The Cardiovascular Research Foundation (CRF) has announced over 30 late-breaking trial and science presentations that will be reported at TCT Connect. TCT, the annual scientific symposium of CRF and the world’s premier educational meeting specializing in interventional cardiovascular medicine, will take place online October 14-18.
International cardiology trial shows potential benefit of using personalized medicine in blood thinner therapy selection
An international, first-of-its-kind cardiology trial used personalized genetic testing to reduce by 34 per cent the number of serious adverse events following balloon angioplasty, a treatment for the most common form of heart disease.
Brooklyn Heart Patient Saves Own Life Amid COVID-19
Ann Apasewicz was hesitant to seek care at the height of the pandemic, but consulting her NYU Langone Hospital—Brooklyn doctor saved her life
TCT 2020 Is Now a Virtual Event: TCT Connect
The Cardiovascular Research Foundation (CRF) has announced that Transcatheter Cardiovascular Therapeutics (TCT) 2020 will now take place as a virtual event called TCT Connect. The event will take place online October 14-18, 2020 and feature live case-based transmissions from around the globe, late-breaking clinical trials and science, virtual training, and countless opportunities to learn and engage with the brightest minds in interventional cardiovascular medicine.
New Research Supports Initial Conservative Management of Stable Coronary Artery Disease
New study results confirm that guideline-directed medical therapy is as effective as more invasive procedures at preventing death, stroke, and heart attack in patients with stable coronary artery disease (CAD).
The study results suggest that guideline-directed medical therapy should be the initial treatment strategy for patients with stable CAD.
The study results validate the evidence-based, guideline-directed, conservative treatment approach that the cardiovascular specialists at Nuvance Health have always used to treat CAD.