Genetic Breakthrough Identifies Heart Failure Risk in African and Latino Americans

Findings may inform genetic screening test for patients at risk and medically under-served

Genetic Variant Largely Found in Patients of African Descent Increases Risk for Heart Failure

A genetic variant in the gene transthyretin (TTR) is a more significant cause of heart failure than previously believed. The study also revealed that a disease caused by this genetic variant, called hereditary transthyretin amyloid cardiomyopathy, is significantly underdiagnosed.

Stem Cell Therapy Helps Broken Hearts Heal in Unexpected Way

A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

Researchers Discover New Mutations in Gene Associated with Disease That Causes Weakening of the Heart

Researchers from the Intermountain Healthcare Heart Institute in Salt Lake City have identified new mutations in a gene commonly associated with non-ischemic dilated cardiomyopathy (NIDC), a disease that weakens the heart muscle, making it more difficult to adequately circulate blood to meet the body’s needs.

Artificial Intelligence Tool Predicts Life Expectancy in Heart Failure Patients

Researchers at University of California San Diego School of Medicine, as well as a diverse team of cardiologists and physicists, developed a machine learning algorithm to predict the life expectancy in heart failure patients.

Pairing New Medications Could Offer Hope to Heart Disease Patients

Cardiologist Bertram Pitt, MD, sees promise in combining two new classes of medication into a treatment regimen for patients with cardiovascular disease. Pitt will discuss the advantages of this treatment plan in his plenary lecture at an American Physiological Society Conference in Estes Park, Colo.

Three-Year COAPT Data Demonstrates Continued Safety and Effectiveness in Patients with Heart Failure and Secondary Mitral Regurgitation

The three-year results from the COAPT trial demonstrated that reducing severe secondary mitral regurgitation (SMR) with the MitraClip device safely improves prognosis in selected heart failure (HF) patients. In addition, those patients that crossed over and received the MitraClip after 24 months showed the same benefits as those who received the device at the beginning of the study. Two-year data were presented at TCT 2018 and published in the New England Journal of Medicine.

Improving Doctor-Patient Communication at the End of Life: Multi-Center Study Suggests It Can Be Done

To find out whether an intervention could increase the number of discussions between clinicians and patients with heart failure about the kinds of treatments they would want at the end of their lives, also known as advance care planning, researchers at The Mount Sinai Hospital developed a rigorous six-center study to investigate a novel communication intervention. The study appears in the Journal of the American College of Cardiology.

Announcing the TCT 2019 Late-Breaking Trials and Science

The Cardiovascular Research Foundation (CRF) has announced the 12 late-breaking trials and 16 late-breaking science presentations that will be reported at the Transcatheter Cardiovascular Therapeutics (TCT) 2019 scientific symposium. TCT, the world’s premier educational meeting specializing in interventional cardiovascular medicine, will take place September 25 – 29, 2019 at The Moscone Center in San Francisco, California.