Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a possible treatment for Alzheimer disease. Working together with a scientific team at The Rockefeller University in New York, the investigators have shown that treatment with the oral anticoagulant…
Tag: Cardiology
Pairing New Medications Could Offer Hope to Heart Disease Patients
Cardiologist Bertram Pitt, MD, sees promise in combining two new classes of medication into a treatment regimen for patients with cardiovascular disease. Pitt will discuss the advantages of this treatment plan in his plenary lecture at an American Physiological Society Conference in Estes Park, Colo.
Temple scientists ID new targets to treat fibrosis — a feature of many chronic diseases
(Philadelphia, PA) – When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term – but…
Heart failure and the obesity paradox
While obesity significantly increases your chances of developing heart failure, for those with established heart failure it may confer a survival benefit compared with normal weight or underweight individuals.
High fiber diet associated with reduced CV risk in hypertension, type 2 diabetes patients
Medical nutrition therapy paired with medical treatment may reduce future heart disease
Tooth loss associated with higher risk of heart disease
Adults missing one or more teeth from nontraumatic events more prone to heart attack, stroke
Fathers-to-be should avoid alcohol six months before conception
Parental alcohol consumption linked to raised risk of congenital heart disease
U of G researchers discover potential drug to treat heart attacks
A potential drug to treat heart attacks and to prevent heart failure — for which no cure currently exists — may result from pioneering research by a University of Guelph professor
CNIC scientists discover a new mechanism for the transfer of maternal genetic material
The study, published in Cell Metabolism, will help scientists devise ways to prevent the co-occurrence of different types of mitochondrial DNA in the same cell as an unwanted result of medical interventions
Protein associated with many diseases fully visualized for first time
New drugs could be inspired by understanding how P2X7 protein receptor works
Poor health more likely to be associated with shorter sleep in older Irish population
Trinity College Dublin researchers have shown that some Irish adults are not ‘getting a good night’s sleep’ resulting in an increased risk of negative health outcomes. The first findings on sleep duration in the older Irish population are published by…
WVU researchers study link between low birth weight and cardiovascular risk
Low birth weight is linked not only to poor health outcomes at birth but also to chronic health conditions later in life. In a recent study, West Virginia University researcher Amna Umer explored how low birth weight correlates to cardiovascular…
Sleeping less than 6 hours and heart disease, stroke — deadly combo
Journal of the American Heart Association report
Physical activity and good fitness improve cardiac regulation in children
A recent Finnish study showed that more physically active and fit children have better cardiac regulation than less active and fit children. The study also showed that cardiac regulation was better especially in boys with better aerobic fitness and in…
Revolutionary simple blood tests for diabetic complications, cancer
A few drops of blood can detect liver cancer, life-threatening complications in diabetics
Skin-Cells-Turned-to-Heart-Cells Help Unravel Genetic Underpinnings of Cardiac Function
A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.
New Self-expanding TAVR Prosthesis Does Not Meet Non-Inferiority Compared to SAPIEN 3
The first randomized trial to compare the safety and efficacy of the new ACURATE neo transcatheter heart valve with the SAPIEN 3 TAVR device did not meet non-inferiority in patients with severe aortic stenosis.
New TAVR System Safe and Effective for High-Risk Surgical Patients with Severe Aortic Stenosis
The Portico IDE study found that 30-day safety and one-year effectiveness outcomes of a novel self-expanding transcatheter aortic valve replacement (TAVR) system for patients with severe aortic stenosis (AS) at high or extreme-risk for surgery was noninferior to contemporary FDA-approved TAVR systems available in the United States.
Three-Year COAPT Data Demonstrates Continued Safety and Effectiveness in Patients with Heart Failure and Secondary Mitral Regurgitation
The three-year results from the COAPT trial demonstrated that reducing severe secondary mitral regurgitation (SMR) with the MitraClip device safely improves prognosis in selected heart failure (HF) patients. In addition, those patients that crossed over and received the MitraClip after 24 months showed the same benefits as those who received the device at the beginning of the study. Two-year data were presented at TCT 2018 and published in the New England Journal of Medicine.
New Five-Year Data Shows Similar Outcomes for TAVR and SAVR in Patients with Severe Aortic Stenosis and Intermediate Surgical Risk
Five-year results from the PARTNER 2A trial found that patients with severe aortic stenosis (AS) and intermediate surgical risk who underwent transcatheter aortic valve replacement (TAVR) had similar rates of death and disabling stroke compared to those who had surgical aortic valve replacement (SAVR). However, TAVR using a transthoracic approach had poorer outcomes compared to SAVR.
New Data Show that Patients with Left Main Disease Treated with PCI or CABG Have Similar Composite Outcomes at Five Years
Patients with left main coronary artery disease (LMCAD) typically have a poor prognosis due to the large amount of myocardium at risk. Revascularization with either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG) has been shown to prolong survival in patients with left main disease compared with medical therapy alone. Three-year data from the large-scale randomized ECXEL trial found no significant difference in the composite rate of death, stroke or myocardial infarction (MI) between the two treatments, with a reduction in 30-day major adverse events with PCI. These results were first reported at TCT 2016 and published in NEJM.
Heart, kidney disease risk factors for adverse effects from gout medication
Heart disease is an independent risk factor for severe adverse skin reactions in patients taking allopurinol, found a study published in CMAJ (Canadian Medical Association Journal) . Allopurinol is a medication most commonly used to treat gout, a painful condition…
In major meta-analysis, omega-3 fish oil supplements linked with lower cardiovasc
Boston, MA – People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events compared with those who were given placebo, according to a new meta-analysis from Harvard…
Statins could increase or decrease osteoporosis risk — the dosage makes the difference
A study by the the Medical University of Vienna and the Complexity Science Hub Vienna shows for the first time a connection between the dosage of cholesterol-lowering drugs and the diagnosis of osteoporosis
Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function
Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications. But since most of these variations fall into areas…
‘Good’ cholesterol counters atherosclerosis in mice with diabetes
Increasing levels of a simplified version of “good” cholesterol reversed disease in the blood vessels of mice with diabetes, a new study finds. Published online in the journal Circulation on September 30, the study results revolve around atherosclerosis, a condition…
Artificial intelligence improves biomedical imaging
Scientists at ETH Zurich and the University of Zurich have used machine learning methods to improve optoacoustic imaging. This relatively young medical imaging technique can be used for applications such as visualizing blood vessels, studying brain activity, characterizing skin lesions…
Simple cardiac risk score can predict problems with blood flow in the brain
HAMILTON, CANADA (Sept. 30, 2019) – A simple cardiac risk score can indicate who may have carotid artery plaque and silent strokes which often come before a serious clinical stroke. The findings come from one of the largest magnetic resonance…
You don’t have to go cold turkey on red meat to see health benefits
A new study has found that halving the amount red and processed (RPM) meat in the diet can have a significant impact on health, reducing the amount of LDL ‘bad’ cholesterol in the blood which cuts the risk of developing…
ACC Middle East Conference tackles new approaches in primary prevention, global burden of NCDs
Partnering with the Emirates Cardiac Society, conference returns to United Arab Emirates
New guidelines: No need to reduce red or processed meat consumption
Embargoed news from Annals of Internal Medicine
Researchers find shorter sleep periods associated with obesity in African Americans
Minority groups susceptible to becoming overweight or obese not included in earlier studies, according to authors in The Journal of the American Osteopathic Association
Risk of heart valve infections rising in hospitals
Rutgers study highlights the need for improved infection prevention strategies
Wrist-worn step trackers accurate in predicting patient health outcomes
Determining how far patients with pulmonary disease can walk in six minutes has long been an effective clinical tool to help physicians determine their exercise capacity, as well as to aid in predicting health outcomes and mortality. Now, in a…
Additional heart artery stenting reduces risk of future heart attacks
Research shows that patients requiring emergency heart attack treatment also benefit from further intervention to reduce risk of future heart attacks The international trial included 4000 patients, 713 of which were from the UK in investigations led by the University…
TCT 2019 Master Operator Award to Be Presented to Shigeru Saito, MD
The Geoffrey O. Hartzler Master Operator Award will be presented to Shigeru Saito, MD, in a ceremony on September 27, 2019 at the 31st Transcatheter Cardiovascular Therapeutics (TCT), the annual scientific symposium of the Cardiovascular Research Foundation (CRF).
When data parasites are a positive – A growing trend of data sharing will move science forward, @umichCVC cardiologist says.
J. Brian Byrd, M.D., M.S., available to discuss advances in data sharing, why it’s so important, and to give an overview of the Research Symbiont Award. It started as an insult, but advocates for data sharing are encouraging people to…
Salt shakers should carry tobacco-style health warning, say experts
Salt sold in supermarkets and salt shakers in restaurants should be required to carry a front-of-pack, tobacco-style health warning, according to The World Hypertension League and leading international health organisations. In a position statement published in the Journal of Clinical…
Optimism associated with lower risk of heart disease, early death
Bottom Line: Optimism was associated with lower risk of cardiovascular events and less risk of overall death in this observational study. The study, called a systematic review and meta-analysis, combined results from 15 studies (10 studies reported data on cardiovascular…
High-speed microscope illuminates biology at the speed of life
Developed by Columbia scientists, New SCAPE 2.0 system can serve as a critical tool to advance science and medicine
Shortened Three-month DAPT Duration After PCI Demonstrates Low Rate of Adverse Events in High-Bleeding Risk Patients
Data from the EVOLVE Short DAPT study found that shortened three-month dual antiplatelet therapy (DAPT) did not increase myocardial infarction (MI) or stent thrombosis (ST) in high bleeding risk (HBR) patients treated with a contemporary drug-eluting stent.
Ticagrelor Without Aspirin Three Months After Successful PCI and DAPT Reduces Major Bleeding Without Increasing the Risk of Adverse Events
New data from the randomized, placebo-controlled TWILIGHT trial found that compared to ticagrelor plus aspirin, ticagrelor monotherapy reduces bleeding events without increasing the risk of death, myocardial infarction, or stroke in high-risk patients who have undergone successful percutaneous coronary intervention (PCI) and completed three months of dual antiplatelet therapy (DAPT).
Biodegradable Polymer Everolimus-eluting Stent with Shortened DAPT is Safe and Effective for PCI in Patients with Unprotected Left Main Coronary Artery Disease
New data from the IDEAL-LM trial found that a biodegradable polymer everolimus-eluting stent (BP-EES) followed by four months of dual antiplatelet therapy (DAPT) was safe and effective compared to a conventional durable polymer everolimus-eluting stent (DP-EES) followed by 12 months of DAPT in patients undergoing PCI for unprotected left main coronary artery (uLMCA) disease.
Durable Polymer Drug-Eluting Stent Noninferior to a Polymer-Free Drug-Coated Stent in Patients at High Risk of Bleeding Treated with One-Month DAPT
The first randomized trial to compare a durable polymer drug-eluting stent to a polymer-free drug-coated stent in patients at high risk of bleeding and treated with one-month dual antiplatelet therapy (DAPT) found that both are clinically safe and effective.
Coronary Stent Patients May Not Need Long-Term Aspirin
Results from international clinical trial ‘TWILIGHT’ could change standard of care for high-risk cases
AI identifies genes linked to heart failure
Genetic research led by Queen Mary University of London could open the way to earlier identification of people at risk of heart failure and to the development of new treatments. The Queen Mary University of London team applied an artificial…
Walking speed may predict return to work in young stroke survivors
Stroke journal report
Noninvasive radiation tx offers long-term benefits to pts with high-risk heart arrhythmia
Image-guided cardiac radioablation dramatically reduces episodes of fast, abnormal heartbeats for more than 2 years
Temple scientists solve mystery underlying heart toxicity caused by diabetes drugs
(Philadelphia, PA) – Like catching two fish with one worm, treating two problems with a single drug is efficient, but exceedingly difficult. In particular, for new diabetes medications, in which one drug aims to tackle two major complications of diabetes…
Pesticide exposure may increase heart disease and stroke risk
Journal of the American Heart Association Report