English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduA team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has discovered that a transcription factor, TOX2, was aberrantly increased in patients with Natural killer/T-cell lymphoma (NKTL). The increased TOX2 level leads to the growth and spread of NKTL, as well as the overproduction of PRL-3 – an oncogenic phosphatase that is a known key player in the survival and metastasis of several other types of cancers. This breakthrough discovery presents a potential novel therapeutic target to treat NKTL.
Month: May 2023
Pan-cancer T cell atlas reveals new details of tumor microenvironment
A new study led by researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Medicine, provides a deeper understanding of the vast diversity of T cell states as well as their relationships and roles within the complex tumor microenvironment, bringing a fresh perspective to understanding immunotherapy efficacy in cancer.
Neighborhood Access to Alcohol Might be Linked to A Raised Risk of Suicide Attempts
Living in a neighborhood with bars or government-run alcohol outlets may increase suicidal behavior among young adults, especially men and those with elevated genetic liability for attempting suicide, a new study suggests. The paper, in Alcohol: Clinical & Experimental Research, is the latest attempt to clarify the link between alcohol accessibility and suicidal behavior. This complex relationship is proving difficult to unravel. Both acute drinking and alcohol use disorder are associated with increased suicide risk, potentially because of behavioral inhibition, depressed mood, or aggression. The link between heavy drinking and suicidal behavior likely reflects, in part, genetic and environmental influences, including the proximity of alcohol outlets. Research has been inconclusive, however. For the new study, drawing on the experiences of hundreds of thousands of individuals in Sweden, investigators explored the association between neighborhood alcohol outlets and suicide attempts and
KRISS Ushers in Era of Green Hydrogen
The Korea Research Institute of Standards and Science (KRISS) has demonstrated the key to the longevous and efficient photoanode with protective film, which is used to produce hydrogen via water splitting using solar energy. This is expected to bring forward the era of environment-friendly “green hydrogen.”
Binge Drinking and Night Shift Work Linked to Greater Likelihood of COVID Infection in Nurses
Working the night shift or binge drinking may double the risk of COVID-19 infection, according to a study of nurses published in Alcohol: Clinical and Experimental Research. Both alcohol misuse and night shift work have been shown to impact sleep and promote inflammation in the body, which has been linked to COVID disease severity. The findings from this study strongly suggest that alcohol and circadian misalignment contribute to the development of COVID disease in people exposed to the virus.
‘Golden’ moment: State Trooper, Montville EMTs honored for quick action that saved a stroke patient
Atlantic Health System honored a New Jersey State Trooper and members of the Montville Township First Aid Squad on Tuesday, May 23, 2023, as the first responders reunited with the man whose life they saved a year earlier when he suffered a stroke while driving along a busy highway.
Access To Quality Anesthesia Care Increased for Indiana Dental Patients
Indiana dental patients now have increased access to safe anesthesia care with the enacting of Indiana Senate Bill 273. The American Association of Nurse Anesthesiology (AANA) applauds the new law, as it expands the scope of practice for Certified Registered Nurse Anesthetists (CRNAs), allowing CRNAs to administer moderate sedation, deep sedation, or general anesthesia to a patient in a dental office, under the direction of and in the immediate presence of a physician.
Facebook fitness and Insta-vitamins: how social media shapes women’s health
A new study led by researchers from the University of Sydney has found young women’s engagement with social media plays a major role in shaping how they think – and act – in relation to their health.
CHOP Researchers Show that IgA Fine Tunes the Body’s Interactions with Microbes
A new study by researchers at Children’s Hospital of Philadelphia (CHOP) has demonstrated that IgA acts as a “tuner” that regulates the number of microbes the body sees every day, restraining the systemic immune response to these commensal microbes and limiting the development of systemic immune dysregulation.
Kids Don’t Always Outgrow Stuttering, SLU Experts Say, But Speech Therapy Can Help
For the parents of children who stutter, managing the communication disorder alone can be stressful and isolating. At Saint Louis University’s Speech-Language and Hearing Clinic, one mother discovered a team to help her daughter communicate more confidently at school and home.
Study: New York’s Bail Reform Law Did Not Increase Crime
New York’s bail reform law had a negligible effect on crime, a study by a recent PhD recipient and a professor in the University at Albany’s School of Criminal Justice found.
Warm and dry climate over China in 2022 with extreme heatwaves and droughts
Weather and climate are important factors affecting economic and social development. In China, the country’s National Climate Center releases an annual climate report that comprehensively covers China’s achievements and progress that year in climate system monitoring, climate impact assessment, and other aspects.
Termite mounds reveal secret to creating ‘living and breathing’ buildings that use less energy
Among the approximately 2,000 known species of termites, some are ecosystem engineers. The mounds built by some genera, for example Amitermes, Macrotermes, Nasutitermes, and Odontotermes, reach up to eight meters high, making them some of the world’s largest biological structures.
How eating natto might help to distress
Health is wealth as the saying goes and new research now shows that it is possible to have a healthy, less stressed society through familiar and inexpensive foods.
Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and have therefore been extensively investigated in preclinical studies of regenerative medicine. However, while MSCs have been shown to be safe as a cellul
Molecular signaling in cancer stem cells of tongue squamous cell carcinoma: Therapeutic implications and challenges
Head and neck squamous cell carcinoma is the seventh most common cancer worldwide with high mortality rates. Amongst oral cavity cancers, tongue carcinoma is a very common and aggressive oral cavity carcinoma. Despite the implementation of
Human pluripotent stem cell-derived extracellular vesicles: From now to the future
Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. Accordingly, in various biological contexts, EVs are reported to engage i
Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. Its continuous renewal or wound healing depends on t
Stromal cell-derived factor-1α regulates chondrogenic differentiation via activation of the Wnt/β-catenin pathway in mesenchymal stem cells
BACKGROUNDMesenchymal stem cells (MSCs) have been applied to treat degenerative articular diseases, and stromal cell-derived factor-1α (SDF-1α) may enhance their therapeutic efficacy. However, the regulatory effects of SDF-1α on cartilag
Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: Advances and challenges
Spinal cord injury (SCI) is a devastating condition with complex pathological mechanisms that lead to sensory, motor, and autonomic dysfunction below the site of injury. To date, no effective therapy is available for the treatment of SCI. R
Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells
Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. It is usually considered that the differentiation process of MSCs depends on specialized
Modulation of stem cell fate in intestinal homeostasis, injury and repair
The mammalian intestinal epithelium constitutes the largest barrier against the external environment and makes flexible responses to various types of stimuli. Epithelial cells are fast-renewed to counteract constant damage and disrupted bar
Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression
Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow (BM). The interaction between MM cells and the BM microenvironment, and specifically BM
Advancements in adipose-derived stem cell therapy for skin fibrosis
Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation and ECM hyperplasia lead
Tissue-specific cancer stem/progenitor cells: Therapeutic implications
Surgical resection, chemotherapy, and radiation are the standard therapeutic modalities for treating cancer. These approaches are intended to target the more mature and rapidly dividing cancer cells. However, they spare the relatively quies
Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations
Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC pa
How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells
Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC pa
Forging a dream material with semiconductor quantum dots
Researchers from the RIKEN Center for Emergent Matter Science and collaborators have succeeded in creating a “superlattice” of semiconductor quantum dots that can behave like a metal, potentially imparting exciting new properties to this popular class of materials.
Yeast screen uncovers genes involved in chromosomal mutation
When creating a computer program, errors in the code can introduce bugs to the software. Similarly, errors in our body’s genetic code, DNA, which is stored in structures known as chromosomes, can bring about mutations in the body.
Scepticism about Microsoft results
In March 2022, Microsoft published research results about the realisation of a special type of particle that might be used to make particularly robust quantum bits.
AMERICAN SOCIETY OF NEPHROLOGY ANNOUNCES LIFETIME AND MIDCAREER 2023 AWARD RECIPIENTS
Each year, ASN recognizes individuals who have demonstrated exceptional leadership and achievements in clinical care, education, and research through our lifetime achievement and midcareer awards. Above all, kidney professionals imbue their work with compassion, dedication, and respect for the people whose lives they improve.
Americans walk less frequently and less safely compared to other countries
A stroll through international statistics about walking reveals the grim reality of foot travel in the United States. “People walk less in the United States because it’s more dangerous to walk here and walking conditions are worse compared to other countries,” said Ralph Buehler, professor of urban affairs and planning at Virginia Tech.
GW Experts Available to Discuss Key Issues for Pride Month
WASHINGTON (May 26, 2023)–June is designated as Pride Month in the United States to commemorate the 1969 Stonewall Uprising in Manhattan. The protests marked the beginning of the gay pride movement and helped launch a civil rights movement for LGBTQ+…
UChicago Medicine introduces groundbreaking, next-generation robotic technology to combat early lung cancer
The University of Chicago Medicine is the first U.S. hospital to use new, state-of-the-art robotic technology for bronchoscopies that will improve early detection of lung cancer. UChicago Medicine performed its first four successful cases using the Noah Medical Galaxy Robot on May 18, 2023. Each patient returned home the same day after the procedure.
University of Rhode Island, Flinders University (Australia) formalize partnership in support of AUKUS Agreement
The University of Rhode Island has formalized a research and education partnership with Australia’s Flinders University that advances AUKUS, a security partnership signed by the governments of the United States, Australia, and the United Kingdom. URI’s agreement with Flinders will bolster Australia’s efforts to produce the skilled workforce it needs to deliver on the AUKUS security pact, which includes a phased approach to build Australia’s undersea capability through the acquisition of conventionally armed, nuclear-powered submarines.
UGA Law professor discusses environmental implications of Sackett decision
On May 25, the Supreme Court issued its decision on Sackett v. EPA, No. 24-454 (2022). University of Georgia School of Law Assistant Professor Adam D. Orford, whose interdisciplinary research investigates legal and policy approaches to environmental protection, has shared…
Johns Hopkins Center for Gun Violence Solutions Hosting Panel Discussion On Alcohol Misuse and Gun Violence June 1 at Noon
The Johns Hopkins Center for Gun Violence Solutions, based at the Johns Hopkins Bloomberg School of Public Health, is hosting an online panel on Thursday, June 1 at noon EDT, to discuss a new report highlighting the dangerous intersection of alcohol misuse and gun violence. The report, “Alcohol Misuse and Gun Violence: An Evidence Based Approach,” was released earlier this month by the Consortium for Risk-Based Firearm Policy, a group of leading experts that advances evidence-based gun violence prevention policies, and the Center for Gun Violence Solutions.
Underused Screening Test Could be Saving More Lives from Lung Cancer
Lung cancer is responsible for more deaths than any other cancer in the country. While using CT scans to screen for lung cancer has been around for about 10 years, experts say this simple test is largely underused. “Unfortunately, many…
Breast, rectal, kidney, and brain cancer phase 3 trials headline Dana-Farber research at ASCO Annual Meeting
Several phase 3 studies conducted by researchers from Dana-Farber Cancer Institute show promising results for patients with rectal, brain, and kidney cancers. The results of these studies, along with dozens of others led by Dana-Farber researchers, will be presented at the 2023 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
Plasma electrochemistry offers novel way to form organic chemical bonds
Plasma engineers and chemists at the University of Illinois demonstrated a sustainable way of forming carbon-carbon bonds — the bedrock of all organic compounds — without expensive rare metals that are typically required as catalysts.
Research specialist on water law available to discuss U.S. Supreme Court decision regarding the EPA and the Clean Water Act
Rutgers expert available for interview on Thursday U.S. Supreme Court decision on EPA and wetlands
Precision Nuclear Physics in Indium-115 Beta Decay Spectrum using Cryogenic Detectors
Scientists test nuclear theory models in mid-sized nuclei using high resolution Indium-115 decay data.
Groundbreaking Images of Root Chemicals Offer New Insights on Plant Growth
Applying imaging technology to plant roots, researchers have developed a new understanding of chemicals that are responsible for plant growth. The chemical “roadmap” identifies where key molecules are distributed along corn roots and how their placement factors into the plant’s maturation.
Climate-stressed trees get a boost from new microbial partnerships
Plants live across wide ranges of heat and cold and rain and drought, but they don’t fill their niches alone. Along with the animals and insects that live on and around a tree — pitching in now and then to aid pollination or pest control or seed dispersal — there are innumerable microbes in the soil (like various fungi that grow alongside tree roots). These microbes can blunt the normal stresses of life by helping trees draw in more nutrients and water or influencing the time they leaf out or flower to best match seasonal conditions.
Polar fish are less likely to die early, so they prioritize growth over reproduction
Polar fish experience lower mortality than tropical fish, allowing them to delay reproduction until later in life when they are larger and can produce more eggs, according to a study by Mariana Álvarez-Noriega at Monash University in Australia and colleagues, publishing May 25th in the open access journal PLOS Biology.
“A blessing in disguise!” Physics turning bad into good
Light is a very delicate and vulnerable property. Light can be absorbed or reflected at the surface of a material depending on the matter’s properties or change its form and be converted into thermal energy.
Statement on Passage of Diagnostic Imaging Legislation in Minnesota
Susan G. Komen thanked lawmakers in Minnesota for passing and Gov. Tim Walz for signing legislation that eliminates out-of-pocket costs for diagnostic and supplemental breast imaging.
UC San Diego Health Experts Available to Discuss Shingles, Ramsay Hunt Syndrome
California Sen. Dianne Feinstein has developed rare complications due to a months-long shingles infection, including encephalitis (brain inflammation) and Ramsay Hunt Syndrome. Ramsay Hunt Syndrome occurs when shingles infects cranial nerves, including the auditory, vestibular and facial nerves, which can…
New insights into bacterial antibiotic resistance
Antibiotic resistance (ARE) is a threat to human health worldwide, as diverse proteins allow pathogenic bacteria to develop increasing levels of resistance to antibiotic medicines.
Sudden infant death syndrome may have biologic cause
Sudden infant death syndrome is a case where the death of an apparently healthy infant before their first birthday remains unexplained even after thorough investigation.