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UrduPeripheral nerve injury (PNI) is a common disease that is difficult to nerve regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting
Tag: Microrna
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
BACKGROUNDThin endometrium seriously affects endometrial receptivity, resulting in a significant reduction in embryo implantation, and clinical pregnancy and live birth rates, and there is no gold standard for treatment. The main pathophysi
Rutgers MicroRNA expert can comment on today’s Nobel Prize in Medicine
Rutgers MicroRNA expert available to comment on today’s Nobel Prize in Medicine Enver Cargri Izgu, an assistant professor in the Department of Chemistry and Chemical Biology at Rutgers University – New Brunswick, is available to speak about the work of…
Small RNAs take on the big task of helping skin wounds heal better and faster with minimal scarring
New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar).
MD Anderson Research Highlights for October 25, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Recent developments at MD Anderson include positive results from a Phase I trial for patients with TP53-mutant acute myeloid leukemia, a novel machine learning platform to identify cancer biomarkers from liquid biopsies, a tumor-specific multi-microRNA delivery system to improve treatment outcomes in glioblastoma, a combination strategy to overcome treatment resistance in KRAS-mutated pancreatic cancer, and a new target for improving treatment response in patients with stomach cancer that has metastasized to the peritoneal cavity.
Researchers combat Zika-associated fetal abnormalities using microRNA
Before SARS-CoV-2 and the COVID-19 pandemic, there was the Zika virus epidemic, lasting from 2015 to 2016.
Researchers develop first method to study microRNA activity in single cells
MicroRNAs are small molecules that regulate gene activity by binding to and destroying RNAs produced by the genes. More than 60% of all human genes are estimated to be regulated by microRNAs, therefore it is not surprising that these small molecules are involved in many biological processes including diseases such as cancer.
Researchers Explore Role of MicroRNA in Development of Muscle Cells
Article title: MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16 Authors: Seongkyun Lim, David Lee, Francielly Morena Da Silva, Pieter Koopmans, Ivan J. Vechetti Jr., Ferdinand von Walden, Nicholas P. Greene, Kevin A. Murach From…
MD Anderson Research Highlights for April 19, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Using CRISPR to detect cancer biomarkers
Only a few forms of cancer can currently be diagnosed using blood samples. Now, researchers reporting in ACS Sensors have developed an easy-to-use method that can detect small amounts of cancer-related molecules in exosomes in plasma and effectively distinguish between malignant and benign samples.
Surprisingly, these microRNAs boost — rather than dampen — protein expression
microRNAs are thought to suppress protein expression in dividing cells, such as tumor cells. But new research in ACS Central Science shows that some of these molecules can elevate the expression of a particular gene in dividing human cells and in cancer cells, challenging conventional wisdom.
MD Anderson and TransCode Therapeutics announce strategic alliance to advance RNA therapies for oncology
MD Anderson and TransCode announced a strategic alliance to advance TransCode’s pipeline of RNA-targeted therapeutic and diagnostic candidates for oncology.
Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease
Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…
Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Protecting lungs from ventilator-induced injury
An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists are working to boost a natural cellular process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators.
MicroRNA Variation in Circulation Could Explain Sex Differences in Heart Health
Article title: Sex-specific alterations in blood-borne factors in physically inactive individuals are detrimental to endothelial cell functions Authors: Ryan M. Sapp, Rian Q. Landers-Ramos, Daniel D. Shill, Catherine B. Springer, James M. Hagberg From the authors: “Our data suggest alterations in…
Understanding Neurodegenerative Disease Such as Alzheimer’s and ALS by Examining the Overlap of microRNAs, Oxidative Stress, and Mitochondria Dysfunction
These aspects may have important implications for the design of new drugs and therapeutic interventions for these progressive and incurable diseases.
Researchers Identify MicroRNA That Shows Promise for Hair Regrowth
Researchers have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.
MicroRNA Exhibit Unexpected Function in Driving Cancer
New research shows that both strands of microRNA cooperate to drive growth and aggressiveness across cancer types, suggesting that these molecules may be more central in deadly cancers than previously thought.