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UrduChemical engineers have found a way to load more drug into a tablet, which could then be made smaller and easier to swallow
Tag: PHARMACEUTICAL SCIENCES
Autobahn Labs, Cold Spring Harbor Laboratory partner to advance novel science to clinic
Expansion to East Coast validates Autobahn Labs’ novel incubator model
NIH grant boosts computational search for cancer drugs
Computer scientist Lydia Kavraki and team developing toolkit to model protein-ligand interactions
New study into green tea’s potential to help tackle COVID-19
As India continues to be ravaged by the pandemic, a Swansea University academic is investigating how green tea could give rise to a drug capable of tackling Covid-19.
Researcher gets $2.7 million grant to study seasonal and universal vaccination in aged populations
ATLANTA–Dr. Sang-Moo Kang, professor in the Institute for Biomedical Sciences at Georgia State University, has received a five-year, $2.7 million federal grant to study seasonal and universal vaccination in elderly populations with pre-existing immunity to influenza viruses. The grant from…
SLAS Discovery’s June issue on synthetic biology available now
Oak Brook, IL – The June edition of SLAS Discovery features the cover article, “A Perspective on Synthetic Biology in Drug Discovery and Development–Current Impact and Future Opportunities” by Florian David, Ph.D. (Chalmers University of Technology, Gothenburg, Sweden), Andrew M.…
SLAS Technology June special issue on 3D cell culture
Oak Brook, IL – The June edition of SLAS Technology is a Special Issue entitled, “Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine.” Free online access to the articles in this collection is courtesy of…
Most Americans support Medicare negotiation despite claims it would hurt innovation
WASHINGTON, DC – JUNE 3, 2021 — A new West Health/Gallup survey finds nearly all Democrats (97%) and the majority of Republicans (61%) support empowering the federal government to negotiate lower prices of brand-name prescription drugs covered by Medicare. Overall,…
Curis, Inc. announces ‘VISTA: A new immune checkpoint in cancer, autoimmunity and beyond’
Experts in the field of immunotherapy will gather virtually on June 18, 2021
The dream team: Scientists find drug duo that may cure COVID-19 together
Preclinical experiments show that the drugs cepharanthine and nelfinavir may be effective treatments for COVID-19
Researchers discover potential new approach to treating psoriatic joint inflammation
(SACRAMENTO, Calif.) – An international team of researchers, led by UC Davis Health , has developed a new therapeutic approach to treating psoriatic arthritis , a chronic inflammatory disease affecting the joints. Using a novel chemical blocker targeting chemokine proteins,…
University study highlights alarming rise in usage and costs of antidepressants
RESEARCHERS at the University of Huddersfield have warned there is an urgent need for the country’s mental health interventions to create strategies optimising the use of antidepressants after conducting a study which has highlighted an alarming rise in relation to…
Antibiotics no help for mysterious lung-scarring disease, large trial finds
Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients…
Target protein identified for improving heart attack treatment
A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack. Published in the Journal of Biological Chemistry , the research suggests that protein…
Activation of carbon-fluorine bonds via cooperation of a photocatalyst and tin
Scientists from Osaka University have succeeded in developing the world’s first organic reaction that selectively converts a specific carbon-fluorine (C-F) bond in perfluorinated compounds to other functional groups
CMU Team develops machine learning platform that mines nature for new drugs
Researchers from Carnegie Mellon University’s Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments. The machine learning algorithms…
MDI Biological Laboratory scientist identifies signaling underlying regeneration
Discovery in Salamanders by James W. Godwin, Ph.D., brings science closer to the development of regenerative medicine therapies
Early exposure to cannabis compounds reduces later neural activity in zebrafish: study
New U of A research has implications for prenatal development in humans.
Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein
Experiments with small molecule have implications for research on aging.
Canadian prescription opioids users experience gaps in access to care
Study suggests people treated for opioid use disorder may face difficulties finding new providers
Vitamin D may not provide protection from COVID-19 susceptibility or disease severity
Observational studies have suggested that increased vitamin D levels may protect against COVID-19. However, these studies were inconclusive and possibly subject to confounding. A study published in PLOS Medicine by Guillaume Butler-Laporte and Tomoko Nakanishi at McGill University in Quebec,…
Prognostic value of troponin I in COVID-19 patients
This article by Dr. Alaa A. Ghaleb and colleagues is published in The Open Cardiovascular Medicine Journal, 2021
Rheumatoid arthritis and systemic lupus erythematosus during COVID-19 quarantine period
The article by Dr. Michael L. Tee and colleagues is published in The Open Rheumatology Journal, 2021
Corning launches HepGo™ assay-ready 3D liver spheroid kits
Corning expands cell culture portfolio with 3D liver models that better recapitulate in vivo behavior and deliver a more physiologically relevant model for improved drug safety and efficacy screening
Cell mechanics research is making chemotherapy friendlier
Malignant tumour cells undergo mechanical deformation more easily than normal cells, allowing them to migrate throughout the body. The mechanical properties of prostate cancer cells treated with the most commonly used anti-cancer drugs have been investigated at the Institute of…
Fight against antibiotic-resistant bacteria has a glowing new weapon
AUSTIN, Texas — In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments…
Novel approaches in treating neurodegenerative disorders
The central nervous system (CNS) is the most vital component of our body, regulating various kinds of daily activities that are essential for our life processes. Keeping the balance between body and brain and maintaining the homeostasis of CNS is…
Deciphering structure of a toxic matter that destroys the nerves in the brain
Alzheimer’s disease – also called dementia – where memory and cognitive functions gradually decline due to deformation and death of neurons, and Parkinson’s disease that causes tremors in hands and arms impeding normal movement are major neurodegenerative diseases. Recently, a…
Skeletal muscle loss exacerbated by diabetes improved with oligo DNA
Skeletal muscle is the largest organ in the body that accounts for 30 to 40% of body weight and is responsible for multiple functions such as energy metabolism and heat production. However, skeletal muscle mass is reduced in some diabetics,…
Conquering COVID-19 with antivirals
The COVID-19 pandemic has seen scientists perform incredible feats in a short amount of time, from developing tests to new types of vaccines. Despite these victories, experts are still working to develop an effective antiviral drug to kill the SARS-CoV-2…
Cleveland clinic researchers identify new drug target for treating aggressive prostate cancer
Findings published in Science Translational Medicine
Good bacteria can temper chemotherapy side effects
Naturally occurring gut bacteria can clean up chemo toxins in the body, study finds
Ultra-low doses of inhaled nanobodies effective against COVID-19 in hamsters
PITTSBURGH, May 26, 2021 – In a paper published today in Science Advances , researchers from the University of Pittsburgh School of Medicine showed that inhalable nanobodies targeting the spike protein of the SARS-CoV-2 coronavirus can prevent and treat severe…
U of M Medical School receives $1.5M for nation’s first ivermectin COVID-19 clinical trial
An expansion of an ongoing outpatient clinical trial, the study now includes metformin, fluvoxamine and ivermectin as possible treatments of COVID-19 and to prevent “long COVID”
Soft X-ray method promises nanocarrier breakthroughs for smart medicine
PULLMAN, Wash. – Before the huge potential of tiny nanocarriers for highly targeted drug delivery and environmental clean-up can be realized, scientists first need to be able to see them. Currently researchers have to rely on attaching fluorescent dyes or…
New research supports pridopidine’s neuroprotective properties in Huntington’s Disease models
Newly published papers further elucidate the mechanisms underlying pridopidine’s neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications…
Racemases: The hunt for drugs to neutralise these critical enzymes
Scientists from the University of Bath in the UK explore racemases and propose strategies for finding drugs that target these important enzymes.
Non-hallucinogenic psychedelic analog reverses effects of stress in mouse study
Free of toxic and hallucinogenic side effects, ibogaine-inspired tabernanthalog shows promise as a potential treatment for the detrimental effects of stress on the brain
USC study reveals potential new treatment target in the fight against COVID-19
Keck School of Medicine of USC researchers identify a novel target and a potential new therapy that could offer an additional treatment option against COVID-19 and some of its variants
Stanford bioengineer aims to turn nature’s virus fighters into powerful drugs
Antimicrobial peptides fight viral diseases but a structural flaw makes them difficult to use as drugs; A deft molecular fix could create synthetic “peptoids” to cure diseases
To make particles flow more efficiently, put an obstacle in their way
Microfluidic chips speed up biological and chemical experiments; researchers made them more efficient by using cleverly designed ‘traffic circles’ to direct the flow of fluids
Implantable piezoelectric polymer improves controlled release of drugs
Repeated tests showed a similar amount of drug release per activation, confirming robust control of release rate
Effectiveness of tocilizumab in patients hospitalized with COVID-19
What The Study Did: This follow-up study of a randomized clinical trial examines the association between survival and C-reactive protein levels in patients hospitalized with COVID-19 who were treated with tocilizumab. Authors: Xavier Mariette, M.D., Ph.D., of the Hôpital Bicêtre…
Flu fighter: Nanoparticle-based vaccine effective in preclinical trials
The vaccine, made of disease-fighting proteins, could boost efficacy, accelerate production of seasonal flu vaccines
Efforts to treat COVID-19 patients chronicled in UC Health medications data
Irvine, Calif., May 21, 2021 – A record of medicine utilization patterns assembled by an interdisciplinary team of researchers at the University of California, Irvine and the UC San Diego School of Medicine reveals the thought, care and scientific rigor clinicians at UC Health medical centers applied in their treatment of patients with COVID-19 in 2020.
Making the gray cells happy
Neutrons show a connection between lithium concentrations in the brain and depression
A peptide that allows cannabis-derived drugs to relieve pain without side effects
Scientists from the Proteomics and Protein Chemistry Research Group and the Neuropharmacology-Neurophar Laboratory have developed a peptide which is an ideal candidate for reducing the cognitive side effects of pain treatment with cannabis derivatives.
Medicare negotiation could save businesses $195 billion and workers another $98 billion
Analysis of H.R. 3 estimates lower commercial market premiums and out-of-pocket costs
Newly identified antibody can be targeted by HIV vaccines
The previously undescribed antibody points to new vaccine strategies for HIV, COVID
Nearly 3% of Americans take immune-weakening drugs that may limit COVID vaccine response
Many are taking steroids that could increase risk of COVID-related hospitalization, researchers say