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UrduCleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease.
Tag: Cardiomyopathy
Virtual drug quiets noise in heart tissue images
Researchers at Washington University in St. Louis have developed a new computational approach to removing movement in images of expanding and contracting heart cells and tissues. By computationally removing movement, the algorithm mimics a drug’s action in stopping the heart, without compromising cellular structure or tissue contractility.
Researchers Use Raman Microspectroscopy to Learn about Cardiomyopathy Mechanisms
Article title: Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy Authors: Lucas Becker, Ivonne A. Montes-Mojarro, Shannon Lee Layland, Ali Nsair, Falko Fend, Julia Marzi, Katja Schenke-Layland From the authors: “In this study, we used…
Heart Checkups Advised for Kids Who Play Sports
Key Takeaways:Sudden cardiac arrest is a leading cause of death among young athletes.Pre-participation heart screenings are advised for athletes ages 12 and above.Cardiac tests can detect 99% of abnormalities.Heart defects don’t prohibit kids from playing sports.The fact that sudden cardiac arrest is a leading cause of death in young athletes seems illogical, provoking an obvious question: “That’s the point,” says Children’s Hospital Los Angeles cardiologist Paul Kantor, MBBCh, MSc, FRCPC.
Transcatheter Mitral Valve Repair in Heart Failure Patients Significantly Reduces Hospitalizations and Improves Survival
Breakthrough findings from study led by Mount Sinai researcher could improve outcomes for high-risk patients
Bridging a Neonate With a Single Ventricle to Heart Transplant
In a rare and high-risk procedure, a 1-month-old baby became the first patient with single-ventricle heart disease to receive a ventricular assist device (VAD) at Children’s Hospital Los Angeles.
Gene therapy corrects mutation responsible for common heart condition, UT Southwestern research shows
Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.
Mayo Clinic Healthcare expert shares heart failure signs, risk factors people may not be aware of
Heart failure may seem like a disease of advanced age, but it can develop at any time in life. And, in many cases, it can be prevented or treated. In this expert alert, Gosia Wamil, M.D., Ph.D., a cardiologist at Mayo Clinic Healthcare in London, explains risk factors, symptoms that people may not be aware of and how heart failure is treated.
New Gene Identified in Arrhythmogenic Cardiomyopathy
Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells.
Pathomechanisms in heart disease discovered
Titin is a “titanically large” protein – the largest in the human body – which enables elastic movements of our muscles, including the heart.
Penn Study Illuminates the Biology of Common Heart Disorder
Dilated cardiomyopathy due to titin gene mutations involves both a shortage of good titin and a buildup of mutant, potentially “bad” titin
Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins ― long linked to neurodegenerative disease ― and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.
Silencing Expression of Specific Gene Variants May Provide Insight for Treatment of Mutation-associated Cardiomyopathy
Article title: Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes Authors: Alexandra Dainis, Kathia Zaleta-Rivera, Alexandre Ribeiro, Andrew Chia Hao Chang, Ching Shang, Feng Lan, Paul W. Burridge, W. Robert Liu, Joseph C. Wu, Alex Chia Yu Chang, Beth…
Cleveland Clinic Researchers Find Rise In Broken Heart Syndrome During COVID-19 Pandemic
Cleveland Clinic researchers have found a significant increase in patients experiencing stress cardiomyopathy, also known as broken heart syndrome, during the COVID-19 pandemic.
FSU researchers help discover new genetic variants that cause heart disease in infants
Florida State University researchers working in an international collaboration have identified new genetic variants that cause heart disease in infants, and their research has led to novel insights into the role of a protein that affects how the heart pumps blood.
Wayne State University team developing new treatments for Barth syndrome
A research team from Wayne State University recently received a $1.5 million grant from the National Heart, Lung, and Blood Institute of the NIH to work on potential new targets for treating Barth syndrome, a rare and life-threatening, X-linked genetic disorder that causes cardiomyopathy and other pathologies.
For Valentine’s Day, Think of Your – and Your Partner’s – Heart Health
CLEVELAND: As Valentine’s Day approaches, a Cleveland Clinic survey finds that two-thirds of Americans (66%) in a committed relationship are concerned with their partner’s heart health. Moreover, 60% of Americans say they are more motivated to live a heart healthy lifestyle for their partners than for themselves. This is especially true for men – 67% compared to 52% for women.
The survey was conducted as part of Cleveland Clinic Heart, Vascular and Thoracic Institute’s “Love your Heart” consumer education campaign in celebration of American Heart Month. It looked at how relationships affect heart health.
Diabetes can independently lead to heart failure, population study shows
Heart problems are a common development for people with diabetes. In fact, about 33% of people in the U.S. admitted to the hospital for heart failure also have diabetes. Heart failure may be the result of a co-condition, such as hypertension or coronary heart disease, but not always.
A study published in Mayo Clinic Proceedings, Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study, examines the idea of diabetic cardiomyopathy and heart failure from the effects of diabetes alone.
Genetic Variant Largely Found in Patients of African Descent Increases Risk for Heart Failure
A genetic variant in the gene transthyretin (TTR) is a more significant cause of heart failure than previously believed. The study also revealed that a disease caused by this genetic variant, called hereditary transthyretin amyloid cardiomyopathy, is significantly underdiagnosed.
Researchers Discover New Mutations in Gene Associated with Disease That Causes Weakening of the Heart
Researchers from the Intermountain Healthcare Heart Institute in Salt Lake City have identified new mutations in a gene commonly associated with non-ischemic dilated cardiomyopathy (NIDC), a disease that weakens the heart muscle, making it more difficult to adequately circulate blood to meet the body’s needs.