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UrduThe CRISPR/Cas9 gene-editing tool is one of the most promising approaches to advancing treatments of genetic diseases – including cancer -, an area of research where progress is constantly being made. Now, the Molecular Cytogenetics Unit led by Sandra Rodríguez-Perales…
Tag: Hematology
The number and clonality of TCRs are associated with the prognosis of colorectal cancer
Colorectal cancer (CRC) is the third most common cancer in the world, with more than one and a half million new cases diagnosed annually. Approximately 20% of diagnosed stage II patients experience relapses after surgery. There is no marker yet…
Temple researchers discover drug resistance mechanism in leukemia, ID treatment strategy
(Philadelphia, PA) – Like packaging designed to create a protective environment around a product, the mix of cells and fluids immediately surrounding human bone marrow provides critical protective and nourishing conditions for hematopoietic – or bone marrow-originating – stem cells.…
$7.1M grant to review opioid alternatives to treating sickle cell disease pain
Five-year study looks at acupuncture and guided meditation to manage sickle cell disease pain
Health care-associated infections among critically ill children
What The Study Did: This observational study looked at changes from 2013 to 2018 in the rates of catheter-associated bloodstream and urinary tract infections among critically ill infants and children the United States. Authors: Heather E. Hsu, M.D., M.P.H., of…
COVID-19 antibodies in donated plasma decline within first months after symptom onset
Longitudinal study of COVID-19 convalescent plasma donors sheds light on ideal timing to donate
Free online blood cancer conference from National Comprehensive Cancer Network (NCCN)
The NCCN Virtual nursing forum and annual congress: hematologic malignancies (#NCCNhem20) will provide the latest evidence & expert consensus on emerging practices and debates in blood cancer treatment, online October 8, 2020 – Saturday, October 10
UM171 saves another life
In a world first, a young man suffering from severe aplastic anemia who could not be helped by standard treatments has been given a life-saving
Lost in Transition: Sickle Cell Clinic Helps Adults Continue Care
Networking California for Sickle Cell Care Initiative supports expansion of San Diego’s only adult sickle cell disease clinic at UC San Diego Health which offers child-to-adult transition health services to patients like Vanessa Hughes.
New Guidelines for Maximizing Cures and Minimizing Side Effects in Children with Hodgkin Lymphoma
The National Comprehensive Cancer Network announces publication of new NCCN Guidelines for Pediatric Hodgkin Lymphoma, one of the most curable forms of pediatric cancer. They synthesize the latest evidence and expert-consensus to make sure every child receives appropriate, but not excessive, treatment.
Cincinnati Children’s research helps pave way for newly approved use of drug
Treatment option for hypereosinophilic syndrome, a group of rare blood disorders, OK’d by FDA
A study could provide guideline for exercise training aimed at high blood pressure patient
Brazilian researchers’ finding that exercising in the evening reduces blood pressure more than in the morning can help health professionals choose the time of day for aerobic training depending on the type of anti-hypertensive drug they take
New NCCN resource for understanding childhood leukemia
New NCCN Guidelines for Patients: Pediatric Acute Lymphoblastic Leukemia offers a comprehensive look at the latest expert recommendations for treating a common, highly-curable childhood and adolescent cancer
Routine blood test predicts increased mortality risk in patients with COVID-19
BOSTON – A standard test that assesses blood cells can identify which patients who are admitted to the hospital with COVID-19 face a high risk of becoming critically ill and dying. This discovery, which is described in JAMA Network Open…
Penn researchers discover potential cause of immunotherapy-related neurotoxicity
A single cell atlas aided researchers in identifying previously undiscovered presence of immunotherapy targeted molecule in brain
American Society of Hematology and Elsevier announce new publishing partnership
Collaboration marks the beginning of a new era in the publication of Blood and Blood Advances, while maintaining the high standards for which these journals are widely recognized
Super-potent blood stem cells discovered in human embryos
Stem cells that form the blood and immune system, so-called hematopoietic stem cells (HSCs), have important applications in the treatment of blood cancers and other diseases of the immune system. Through blood stem cell transplantation, healthy blood stem cells can…
The Josep Carreras Institute identifies a marker of poor evolution in Hodgkin’s lymphoma
The marker that allows predicting which patient with Hodgkin’s lymphoma will present an aggressive clinical course, and will therefore be a case of special risk.
COVID ventilator patients can have permanent nerve damage
Prone positioning saves lives, but nerve pressure injuries impair arms and legs
Researchers discovered a novel gene involved in primary lymphedema
Reseachers have made an important discovery how mutations in a novel gene, ANGPT2, cause a lymphatic disease called primary lymphedema. Discovery is essential for the proper diagnosis of patients suffering from primary lymphedema.
Study takes us a step closer to a universal antibody test for COVID-19
Team led by Houston Methodist addresses need for quick, easy tests to screen plasma donors
Metabolite signature of COVID-19 reveals multi-organ effects
SARS-CoV-2, the virus responsible for COVID-19, can cause a wide range of symptoms, from none at all to severe respiratory stress, multi-organ failure and death. The virus notably targets the lungs, but many patients also experience non-respiratory symptoms. Now, researchers…
Small Study Shows Convalescent Plasma is Safe to Use in Pediatric Patients with COVID-19
Early findings from researchers at Children’s Hospital of Philadelphia (CHOP) show that convalescent plasma appears to be a safe and possibly effective treatment for children with life-threatening cases of COVID-19. The results were published online Friday by the journal Pediatric Blood and Cancer.
Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections
BOSTON – Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood clots such as deep vein thrombosis or pulmonary embolism, investigators at Massachusetts…
New insights into why people with down syndrome are at higher risk for leukemia
Findings carry potential for new therapeutic targets for leukemia
Small study shows convalescent plasma is safe to use in pediatric patients with COVID-19
The first study to report on convalescent plasma in life-threatening cases of the virus makes the case for a larger, randomized trial
Prophylactic antivirals prevent chronic HCV in patients receiving kidneys from positive donors
Embargoed News from Annals of Internal Medicine
Blood breakdown product commandeers important enzyme
Researchers at the University of Bonn discover unexpected interaction between the protein APC and heme
Genetic information can predict predisposition to rare and common blood diseases
Studies identify bulk of genetic variation that influences blood cell traits
Kidneys infected with hepatitis C can be safely transplanted into healthy recipients
BOSTON – Kidneys from deceased donors with hepatitis C virus (HCV) infection can be safely transplanted into noninfected recipients when a regimen of direct-acting antiviral therapies is initiated as early as two days after the transplant, according to a study…
RethiNKing which immune cells are the best weapon against lung cancer
Immune cells called ‘natural killer’ (NK) cells could be a powerful weapon for fighting lung cancer, according to Australian researchers. Studying preclinical and patient samples of small cell lung cancer (SCLC), the Walter and Eliza Hall Institute team revealed that…
AGA recommends bidirectional endoscopy for most patients with iron deficiency anemia
Early gastrointestinal evaluation can lead to the identification and treatment of underlying causes such as gastrointestinal malignancy, peptic ulcer disease and inflammatory bowel disease
EBMT trial shows improvements in treatment of Severe Aplastic Anaemia
The European Society for Blood and Marrow Transplantation (EBMT), Europe’s collaborative peer network of professionals working in the field of stem cell transplantation and cellular therapy, announced today the results of the phase III RACE trial during EBMTs virtual 46th…
Host tissue T cells may have an unexpected role in graft-versus-host disease
Results could someday change therapy for hematopoietic stem cell transplant patients and prevent progression of the disease
Blood pressure medication improves COVID-19 survival rates
Medication for high blood pressure could improve Covid-19 survival rates and reduce the severity of infection – according to new research from the University of East Anglia.
Machines rival expert analysis of stored red blood cell quality
New AI strategies automate assessments of stored blood, remove human subjectivity
Wearable sensors printed on natural materials analyze substances present in sweat
Applied to skin as a piece of sticking plaster, the device developed by Brazilian researchers can be used to monitor human metabolism and administer drugs
Exploring connections between ovarian cancer and blood cells
Dr. Abhishek Jain, assistant professor in the Department of Biomedical Engineering and the Department of Medical Physiology in the College of Medicine, collaborated with researchers from the Departments of Gynecologic Oncology and Cancer Biology at MD Anderson Cancer Center to…
Study: Medical marijuana associated with fewer hospitalizations for individuals with SCD
Obtaining medical marijuana also associated with an increase in use of edible cannabis products
NUS research breakthrough: CircASXL1-1 regulates BAP1 deubiquitinase activity in leukemia
Every year, 1.1 million new cases of blood cancers are diagnosed worldwide. Presently, chemotherapy remains the most common and effective course of treatment. However, the emergence of more aggressive forms of leukemia in adults prompts a need for early detection…
Preliminary study of 300+ COVID-19 patients suggests convalescent plasma therapy effective
American Journal of Pathology publishes efficacy results from Houston Methodist clinical trial
Strong link found between abnormal liver tests and poor COVID-19 outcomes
New Haven, Conn. — Researchers at the Yale Liver Center found that patients with COVID-19 presented with abnormal liver tests at much higher rates than suggested by earlier studies. They also discovered that higher levels of liver enzymes — proteins…
ASH releases new clinical practice guidelines on acute myeloid leukemia in older adults
Evidence-based guidelines to help tailor treatment for older people with blood cancer
Identified gene mutations impact on the severity of a type of hematologic cancer
The Myelodysplastic Syndromes Group of Josep Carreras Leukaemia Research Institute, led by Dr. Francesc Solé, has participated in the first international study that confirms that having two mutated copies of the TP53 gene, as opposed to a single mutated copy,…
Iron study combats anaemia with cutting-edge computer simulation
A new iron intervention study has determined which of the world’s low-and-middle income countries would benefit from using iron-containing micronutrient powders to tackle childhood anaemia. Using advanced computer simulation techniques, the study’s findings include individual reports for 78 countries –…
Elevated levels of a specific protein found to correlate with inflammatory symptom severity in COVID
Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia
‘Self-eating’ process of stem cells may be the key to new regenerative therapies
Penn study uncovers new roles of autophagy in stem cell renewal and differentiation
Covid-19 Blood Clotting Cause Identified in Study
New findings led by Yale Cancer Center researchers and experts across several medical specialties at Yale identify a leading mechanism behind the pathophysiology of Covid-19 and pinpoint a biological marker for the mechanism that may aid in treating these patients.
Erlanger Health System and Vanderbilt-Ingram Cancer Center Announce Intent to Collaborate in Cancer Care
Erlanger Health System and Vanderbilt University Medical Center, on behalf of Vanderbilt-Ingram Cancer Center (VICC), have entered into an agreement to design a long-term collaboration in cancer care, including VICC hematology-oncology services at Erlanger’s two clinic and infusion locations.
Simple bed-side test detects bleeding risk in patients after surgery or major injury
Impaired blood clotting after surgery or major injury can lead to severe bleeding or hemorrhage in patients if they are not rapidly treated with blood transfusions. A team led by investigators at Massachusetts General Hospital has developed a novel, inexpensive…