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UrduLimited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
Tag: Hematology
New toolkit aims to improve quality of thrombosis data in COVID-19 trials
The ASH Research Collaborative and International Society on Thrombosis and Haemostasis define thrombosis-related endpoints to inform COVID-19 clinical trial design
Cancer researchers identify potential new class of drugs to treat blood and bone marrow cancers
Cleveland Clinic research team publishes findings in Blood Cancer Discovery
Experience “Innovation Uninterrupted” with Sysmex America at AACC 2020
Sysmex America, Inc., a leading diagnostic solutions company offering hematology, urinalysis, information systems and flow cytometry testing technology for optimal clinical laboratory performance, will be exhibiting virtually at the 72nd AACC Annual Scientific Meeting & Clinical Lab Expo, December 14 – 17.
New analysis method for predicting the risks and effects of immunotherapy
In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphocytic leukaemia.
How blood and wealth can predict future disability
Peer Reviewed – Survey – Humans
Using light, red blood cells and a honey bee peptide to deliver therapeutic proteins
Protein therapies are often more potent and selective toward their biochemical targets than other types of drugs, particularly small molecules. However, proteins are also more likely to be quickly degraded by enzymes or cleared from blood by the kidneys, which…
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Researchers at Children’s Hospital of Philadelphia (CHOP) have found elevated levels of a biomarker related to blood vessel damage in children with SARS-CoV-2 infection, even if the children had minimal or no symptoms of COVID-19. They also found that a high proportion of children with SARS-CoV-2 infection met clinical and diagnostic criteria for thrombotic microangiopathy (TMA). TMA is a syndrome that involves clotting in the small blood vessels and has been identified as a potential cause for severe manifestations of COVID-19 in adults.
New method to boost supply of life-saving stem cells
Haematopoietic stem cell scarcity is one of the biggest barriers to the development of new and improved treatments for blood cancers and disorders
Elevated biomarker for blood vessel damage found in all children with SARS-CoV-2
Study found high proportion of children with SARS-CoV-2 infection met clinical criteria for thrombotic microangiopathy
Dr. Stephanie Halene Appointed Chief of Hematology at Yale Cancer Center and Smilow Cancer Hospital
Following an extensive national search, Stephanie Halene, MD, PhD, has been appointed Chief of Hematology at Yale Cancer Center, Smilow Cancer Hospital and the Yale School of Medicine Department of Internal Medicine.
Yale Cancer Center Study Shows Caplacizumab Not Cost Effective for Rare Blood Disorder
In a new study by Yale Cancer Center researchers, the drug caplacizumab is shown not to be cost-effective in treating thrombotic thrombocytopenic purpura (TTP) when added to the standard-of-care.
Circulating tumor DNA indicates increased risk of relapse after stem cell transplant in patients with diffuse large B-cell lymphoma
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse.
Environmental Surface Testing in Inpatient and Outpatient Hematology/Oncology Settings Shows Negligible Detection of SARS-CoV2
Researchers from Rutgers Cancer Institute of New Jersey evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility. The study revealed extremely low detection of SARS-CoV-2 on environmental surfaces across multiple outpatient and inpatient oncology areas, including an active COVID-19 floor.
Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood…
New treatment uncovered for AL amyloidosis to be announced at ASH Meeting
PORTLAND, OR – Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that isatuximab, a monoclonal antibody approved for the treatment of…
Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute.
Study reveals surprising benefit of clonal hematopoiesis in allogeneic transplants
Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don’t have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.
Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. Venetoclax targets cancer’s survival proteins,…
Identifying markers of COVID-19 infection using blood tests
Researchers from the Institute of Biomedicine of Seville (IBIS) have presented a study carried out in the Clinical Biochemistry Service of the Virgen del Rocío University Hospital which identifies the values for six biochemical biomarkers that indicate a patient may be infected with SARS-COV-2 (COVID-19).
Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society…
Octapharma presents research on congenital & acquired bleeding disorders at ASH Meeting
Research evaluates use of fibryga®, Octaplas™, and Octaplex® as investigational therapies
What makes psoriasis sore: Novel role of immune system in the disease
Scientists uncover another one of the complex immune-mediated mechanisms behind severe psoriasis lesions
US state government crisis standards of care guidelines
What The Study Did: State crisis standards of care (CSC) guidelines in the U.S. allocate scarce health care resources among patients, and this study examined the implications of these guidelines for patients with cancer, including allocation methods, cancer-related categorical exclusions…
Rutgers Cancer Institute of New Jersey to Present Expansive New Hematology Data at the 62nd ASH Annual Meeting and Exposition
The American Society of Hematology (ASH), is the world’s largest professional society with a focus on the causes and treatment of blood disorders. Experts from Rutgers Cancer Institute of New Jersey will be presenting a variety of key hematology data at the 62nd American Society of Hematology Annual Meeting. This includes 22 scheduled presentations, including 10 oral presentations examining several types of blood cancers including leukemia, lymphoma, and myeloma.
Octapharma presents results of study on Octagam® 10% for severe COVID-19 patients at ASH
IVIg portfolio also featured in study design poster on primary infection prophylaxis in patients with chronic lymphocytic leukemia
Study finds 10 metabolites associated with risk of stroke
MINNEAPOLIS – Metabolites are small molecules found in our body’s cells. They come from the food we eat, chemical processes happening within our bodies and microbes. A new analysis of recent studies has found that the levels of 10 metabolites…
Hematologist/Stem Cell Biologist to Direct Hematology and Cellular Therapy at Cedars-Sinai
Internationally recognized hematologist John P. Chute, MD, has been selected to direct the Division of Hematology and Cellular Therapy in the Department of Medicine at Cedars-Sinai Cancer. The physician-scientist also will serve as director of the Center for Myelodysplastic Diseases Research and associate director of the Board of Governors Regenerative Medicine Institute in the Department of Biomedical Sciences.
Octapharma USA presents bleeding disorders research at virtual ASH annual meeting
NUWIQ® & WILATE® utilized in research presented at hematology medical congress
A new spin-off company to develop the first treatment against pulmonary fibrosis based on telomerase
After several years of research and many joint scientific publications, molecular biologists Maria Blasco (National Cancer Research Centre, CNIO) and Fàtima Bosch (Universitat Autònoma de Barcelona, UAB) have developed a telomerase gene therapy for the treatment of different pathologies related…
Researchers tackle sickle cell disease with CRISPR-based gene editing
$1 million grant will advance personalized medicine using gene editing at ChristianaCare’s Gene Editing Institute
Tel Aviv University study finds hyperbaric oxygen treatments reverse aging process
First clinical trial reverses two biological processes associated with aging in human cells
EBMT and EHA aim to position Europe in the lead of the global cellular therapy field
New GoCART coalition
BrainCool’s IQool™ system aligns with New American Heart Association Guidelines
New technology provides optimal cardiopulmonary resuscitation (CRP) and emergency cardiovascular care (ECC) for patients undergoing targeted temperature management
EBMT 47th Annual Meeting
The EBMT is honoured to invite you to the 47th EBMT Annual Meeting, which will take place virtually, 14th-17th March, 2021. More than 6,000 delegates attend the EBMT Annual Meeting. Our top-notch scientific programme for physicians, nurses, data and quality…
Non-hereditary mutation acts as natural gene therapy in patient with rare disease
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations.
Two anti-inflammatory compounds shown to be capable of accelerating recovery from COVID-19
Monoclonal antibody tested by researchers at University of São Paulo and experimental drug given to patients in Italy by University of Pennsylvania research group promoted rapid improvement of respiratory function in patients in severe condition
Personalized cancer vaccine clinical trial to expand following promising early results
A study led by University of Arizona Health Sciences researcher Dr. Julie Bauman that’s investigating a personalized cancer vaccine has reported a 50% response rate for patients with head and neck cancer in its preliminary data
WEHI joins forces with World Health Organisation to combat anaemia
The World Health Organisation (WHO) has designated Australian medical research institute WEHI as the WHO Collaborating Centre for Anaemia Detection and Control, in recognition of WEHI researchers’ expertise in combatting anaemia. The designation enlists WEHI researchers to advise the WHO…
The natural artistry of disease: a wintry landscape in the eye
Researchers from Tokyo Medical and Dental University (TMDU) report a case of frosted branch angiitis in a woman presenting years after being treated for leukemia-lymphoma with allogeneic human stem cell transplant. Tokyo, Japan – Leukemias and lymphomas are life-threatening malignancies…
Radical diagnostic could save millions of people at risk of dying from blood loss
– In a world-first, engineers at Monash University in Australia have developed a diagnostic that can help deliver urgent treatment to people at risk of dying from rapid blood loss. – This simple, cheap and portable diagnostic measures fibrinogen concentration…
Early indications of thrombosis help in preventing postoperative complications
A paper saw light in Scientific Reports
Study in Nature Medicine shows superior patient outcomes in LLS’s Beat AML clinical trial
Rye Brook, NY (Monday, October 26, 2020) – Patients participating in The Leukemia & Lymphoma Society’s (LLS) groundbreaking precision medicine Beat AML Master Clinical Trial had superior outcomes compared to acute myeloid leukemia (AML) patients who opted for standard chemotherapy…
Poverty linked to higher risk of death in children with cancer undergoing transplant
Having Medicaid confers poorer overall survival in children receiving advanced cancer care
Standalone D-dimer test strategy may simplify diagnosis of deep vein thrombosis
Alternative to traditional DVT diagnostic workup could reduce time and cost
Research could change how blood pressure is managed in spinal cord injury patients
New research from the International Collaboration on Repair Discoveries (ICORD) challenges the current standard for managing blood pressure in people with spinal cord injury (SCI). The findings, published today in Nature Communications , could lead to a change in the…
New technology diagnoses sickle cell disease in record time
Researchers at the University of Colorado Boulder and the University of Colorado Anschutz Medical Campus have developed a new way to diagnose diseases of the blood like sickle cell disease with sensitivity and precision and in only one minute. Their…
Researchers identify the mechanism behind bone marrow failure in Fanconi anaemia
Researchers at the University of Helsinki and the Dana-Farber Cancer Institute have identified the mechanism behind bone marrow failure developing in children that suffer from Fanconi anaemia
Studies offer new evidence for possible link between blood type & COVID-19 susceptibility
Individuals with blood type O may have lowest risk of infection; individuals with A and AB may have increased risk of severe clinical outcomes
New blood test predicts which COVID-19 patients will develop severe infection
Test could inform doctors on best treatment options