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UrduResearchers at the UNC School of Medicine were awarded $2.3 million from the National Institute of Arthritis, Musculoskeletal and Skin Diseases to study the genetic basis of a chronic skin condition called hidradenitis suppurativa.
Tag: GWAS
Largest-Ever Genetic Study of Suicide Finds New Risk Factors
The reasons why people attempt suicide are complex and include external triggers like trauma and stress, as well as inherited genetic factors. A new study has identified 12 DNA variants, or variations in the human genetic code, that are associated with risk of attempting suicide.
Largest genetic study of epilepsy to date provides new insights on why epilepsy develops and potential treatments
The largest genetic study of its kind, coordinated by the International League Against Epilepsy (ILAE), has discovered specific changes in our DNA that increase the risk of developing epilepsy.
Study identifies new dementia risk genes through novel testing approach
A new UCLA-led study has identified multiple new risk genes for Alzheimer’s disease and a rare, related brain disorder by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.
A Stem Cell Model From Mount Sinai Could Help Unravel the Complex Biology Behind Some Psychiatric Disorders
Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.
First of its kind study using multi-omics approach identifies large list of candidate genes associated with alcohol use disorder
New York, NY (Aug 20, 2021) – Researchers from the Icahn School of Medicine at Mount Sinai have published the first study of its kind in the field of addiction genetics using a multi-omics approach to provide a large list…
New Alzheimer’s treatment targets identified
A research team at Washington University School of Medicine in St. Louis has identified potential new treatment targets for Alzheimer’s disease, as well as existing drugs with therapeutic potential.
Genetic Tools Help Identify a Cellular Culprit for Type 1 Diabetes
By mapping its genetic underpinnings, researchers at University of California San Diego School of Medicine have identified a predictive causal role for specific cell types in type 1 diabetes, a condition that affects more than 1.6 million Americans.
Pitt Scientists Identify Genetic Risks of Rare Inflammatory Disease
A group of international collaborators led by researchers from the University of Pittsburgh identified new genetic associations that can predict individual susceptibility to Takayasu arteritis.
CHOP Genomic Study Reveals Role for Hypothalamus in Inflammatory Bowel Disease
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children’s Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. The researchers went on to implicate new genes involved in IBD risk that are enriched in both derived hypothalamic neurons, from a part of the brain that has a vital role in controlling stress and depression, and organoids derived from colon cells, a region more commonly studied in the context of IBD.
First-in-Kind Study Reveals Genetic Markers of Type 2 Diabetes in East Asians
This research, published in Nature, shows how different populations of people share most of the genetic susceptibilities to developing type 2 diabetes but do have some different genetic variations that can make them more or less susceptible to developing the condition.
Crowdsourcing Science: Using Competition to Drive Creativity
Thanks largely to advances in computing, researchers in computational biology and data science are harnessing the power of the masses and making discoveries that provide valuable insights into human health.
Polygenic risk score improves psychosis risk prediction
A new study led by researchers at the University of North Carolina at Chapel Hill has found that that using a polygenic risk score (PRS) based on data from genome-wide association studies (GWAS) improves psychosis risk prediction in persons meeting clinical high-risk criteria.
Skin-Cells-Turned-to-Heart-Cells Help Unravel Genetic Underpinnings of Cardiac Function
A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.