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UrduThe Konstanz-based research in the area of cellular proteostasis will receive funding in the amount of approximately EUR ten million for another four years, at the end of which it will have reached its maximum funding period of twelve years.…
Tag: Cancer
Cellular origins of pediatric brain tumors identified
Researchers make a breakthrough by identifying that several aggressive pediatric brain tumors are the result of stalled development in embryonic cells
New approach to treating incurable leukemia in children discovered
Acute lymphoblastic leukemia (ALL) is a form of blood cancer that primarily affects children and young people. It involves large quantities of malignant progenitor cells building up in a person’s blood instead of healthy white blood cells. This is often…
NF decline but stable QOL in 1st year after temozolomide-based chemoradiotherapy
NRG oncology trial shows neurocognitive function decline but stable quality of life in first year after temozolomide-based chemoradiotherapy for patients with high risk, low-grade gliomas
Encouraging normal liver cells to fight cancer
A study conducted at the VIB-KU Leuven Center for Cancer Biology discovered that healthy liver tissue surrounding a tumor activates a defence mechanism that restrains tumor growth. Remarkably, the researchers found that hyperactivation of this mechanism above levels normally present…
Study reveals lower rates of cancer and early death in Adventists, including among black individuals
A recent study found lower rates of premature death and cancer in Seventh-day Adventists, a Protestant denomination long known for health promotion, compared with individuals in the general U.S. population. Published early online in CANCER , a peer-reviewed journal of…
Breakthrough in understanding common childhood cancer
Scientists studying one of the most common forms of childhood cancer have made an important breakthrough in understanding how the disease progresses. Neuroblastoma is a rare type of cancer of the nervous system that mainly affects babies and young children.…
Safety evaluation of conditionally immortalized cells for renal replacement therapy
Here, the research team assessed the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, by using in vitro assays and athymic nude rats
Anchored by a dense neighborhood: What stops cells from going astray
Researchers from the Mechanobiology Institute (MBI) at the National University of Singapore have shown that cells can attach to the fibrous protein meshwork that surrounds them only if the fibres are spaced close enough. The team’s findings, which can explain…
High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target
The cover for issue 61 of Oncotarget features Figure 4, ‘The influence of stress conditions on API-5 expression and inhibition,’ by Bousquet, et al.
Recovering from metabolic syndrome significantly reduces risk for cardiovascular disease
Embargoed News from Annals of Internal Medicine
Prostate cancer: radiation therapy effective in patients with no further treatment options
Reports of new cancer treatments often raise high hopes and expectations, particularly, of course, among cancer patients and their families. But raising expectations is not something that Samer Ezziddin, Professor of Nuclear Medicine and Director of the Department of Nuclear…
Using gene scissors to detect diseases
The CRISPR/Cas technology can do more than alter genes. A research team at the University of Freiburg is using what are known as gene scissors – which scientists can use to edit genetic material – in order to better diagnose…
Cancer patients are at higher risk of dying from heart disease and stroke
More than one in ten cancer patients do not die from their cancer but from heart and blood vessel problems instead, according to new research published in the European Heart Journal [1] today (Monday). For some cancers, like breast, prostate,…
‘Magic bullet’ takes aim at pancreatic cancer
Every day, more than 1200 people worldwide are told they have pancreatic cancer. Within 12 months, 80 per cent of them will have succumbed to the disease. It’s one of the most lethal cancers in the world but new research…
Using Artificial Intelligence to determine whether immunotherapy is working
Researchers use AI with routine CT scans to predict how well lung cancer patients will respond to expensive treatment based off changes in texture patterns inside and outside the tumor.
New study shows how cancer survivors develop opioid addictions
Opioids play an important role in how cancer patients manage pain, but the ongoing opioid epidemic has raised concerns about their potential for abuse. Pain remains one of the most difficult symptoms associated with cancer. More than half of cancer…
New study provides insight into the mechanisms of blood clots in cancer patients
Findings may provide new target for reducing cancer-associated complications
Tiny devices made of DNA detect cancer with fewer false alarms
DNA circuits could help ensure that cancer screens and therapies zero in on the right culprits
Biosimilar for HER2+ breast cancer: Overall response rate matches reference trastuzumab
ESMO Asia Congress 2019
Combination of immunotherapy and VEGF inhibitor improves survival in HCC
ESMO Asia Congress 2019
Breast cancer recurrence after lumpectomy & RT is treatable with localized RT without mastectomy
NRG Oncology trial shows that breast cancer recurrence after lumpectomy and radiation is treatable with localized radiation without mastectomy
Ohio State-developed drug receives FDA approval for treatment of CLL and SML
COLUMBUS, Ohio – On Nov. 21, 2019, the U.S. Food and Drug Administration (FDA) approved the use of the drug acalabrutinib for first-line therapy in chronic lymphocytic leukemia (CLL) and small cell lymphoma (SCL). This is the first full approval…
In a first for cell biology, scientists observe ribosome assembly in real time
The imaging feat clarifies how RNA molecules fold — and might one day translate into better medicines for a host of diseases
Department of Defense awards grant to Stephenson researcher for lung cancer study
OKLAHOMA CITY – Cancer researchers operate from a fundamental premise: Tumor cells are very smart. Because of their ability to disguise themselves, hide or otherwise evade the immune cells that can kill them, the key to successful treatment depends upon…
Non-coding DNA located outside chromosomes may help drive glioblastoma
Extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going — elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat
CDC funds new breast cancer survivorship research at UIC
$1.8 million grant seeks to reduce disparities
UTSA to unlock the power of sulfur in future drug design
Organosulfur compounds are widely present in our bodies and the natural environment. They are found in onions, shallots and even cauliflower. Medical research finds that when consumed, they can protect against cancer, heart disease and even diabetes. There is also…
‘Combo’ nanoplatforms for chemotherapy
In a paper to be published in the forthcoming issue in NANO , researchers from Harbin Institute of Technology, China have systematically discussed the recent progresses, current challenges and future perspectives of smart graphene-based nanoplatforms for synergistic tumor therapy and…
Competing signals shrink or grow liver tumor at the margins
Activating the Hippo molecular signaling pathway in liver tumor cells drives tumor growth–but activating the same pathway in healthy cells surrounding the tumor suppresses tumor growth. This unexpected effect indicates that there is a competitive interaction between tumor cells and…
Ivy Brain Tumor Center and SonALAsense to test drug-device combination for glioblastoma
First-in-human clinical trial will determine effectiveness of promising, non-invasive therapy for brain cancer
Predicting metastasis from primary tumor size
New mathematical model calculates chances that undetectable metastases are present
Cancer linked with a more than doubled risk of dying from stroke
People living with or beyond cancer are more likely to die from stroke than the general public, according to new Penn State research, and certain types of cancer may boost the risk even more. Researchers at Penn State College of…
Despite political turmoil, international collaboration continues to flourish
Latest Nature Index supplement shows US-China research collaborations to be stronger than ever, while UK-EU collaborations stall
Pancreatic cancer tumor classification could optimize treatment choices
CHAPEL HILL — A study from the University of North Carolina Lineberger Comprehensive Cancer Center could help predict resistance to treatments for pancreatic cancer, one of the deadliest cancer types. In Clinical Cancer Research , a journal of the American…
Survey finds 1 in 3 patients needed more information on cancer treatment side effects
One in three adults treated for cancer may experience side effects from treatment they wish they had known more about, according to a new survey published in the Journal of Oncology Practice. The national survey of more than 400 U.S. adults, which was sponsored by the American Society for Radiation Oncology (ASTRO), also found that nine in 10 patients felt they made the right treatment decision despite the desire for more information about treatment side effects.
How do gliomas evolve?
The Glioma Longitudinal Analysis (GLASS) Consortium finds longitudinal molecular trajectories of diffuse glioma in adults
Scientists find promising drug combination against lethal childhood brain cancers
Studies in cell and animal models reveal insights into cancer cells’ vulnerability that could lead to new strategies against brain cancers
Study examines Appalachian Kentucky’s breast cancer care disparities
LEXINGTON, Ky. (Nov. 20, 2019) — It is estimated that nearly 40 percent of women diagnosed with breast cancer will require a mastectomy. For those patients, breast reconstruction surgery is a valuable part of comprehensive breast cancer care as studies…
Mayo Clinic, Hitachi to build first, next generation, carbon ion therapy treatment facility in North America
Mayo Clinic and Hitachi, Ltd. have reached an agreement in principle to build a carbon ion treatment facility as part of Mayo Clinic’s recently announced integrated oncology facility which will be constructed at Mayo Clinic’s campus in Jacksonville, Florida.
Anal cancer rates and mortality have risen dramatically among Americans
Rates of new anal cancer diagnoses and deaths related to human papillomavirus (HPV), the most common sexually transmitted infection, have increased dramatically over the last 15 years, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). The results of their study will be published in the November issue of the Journal of the National Cancer Institute.
Tiny filters help detect cancerous blood cells
A computer model is used to guide the design of tiny pillars in a microfluidic device used to detect malignant multiple myeloma cells
Milestone reached in new leukemia drug
Cold Spring Harbor Laboratory scientists, with chemists and cancer biologists from Dana-Farber Cancer Institute (DFCI), have developed a new therapy that extended the survival of mice with acute myeloid leukemia. The scientists are the first to demonstrate the anti-cancer effect…
Children’s Tumor Foundation and DELopen increase access to compounds for neurofibromatosis
New York: November 19, 2019 – The Children’s Tumor Foundation (CTF), an innovative and global neurofibromatosis (NF) research foundation announced today a collaboration with DELopen, a DNA-encoded library technology platform sponsored by WuXi AppTec, a leading global provider of R&D…
Radiation from CT scans associated with increased risk for cancer
A new study in JNCI Cancer Spectrum finds that exposure to radiation from CT scans is associated with higher risks of developing thyroid cancer and leukemia. Researchers here conducted study from a National Health Insurance dataset in Taiwan between 2000…
Cell death or cancer growth: A question of cohesion
Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death – or does the opposite, namely stimulates cancer cell growth. Scientists from the German Cancer Research Center (DKFZ) have now shown that the impact of CD95…
New pulsed electric field technology could lead to less invasive tumor molecular profiling
Electroporation bears less of the negative consequences of biopsies, say Tel Aviv University, IDC, Technion researchers
25 years of learning to combat cervical cancer
According to the World Health Organization, cervical cancer is the fourth most common type of cancer affecting women worldwide. Currently, early screenings of pre-cancerous tissues and vaccination have proven to be the most effective treatment strategies. However, the lack of…
Tiny filters help detect cancerous blood cells
A computer model is used to guide the design of tiny pillars in a microfluidic device used to detect malignant multiple myeloma cells
A new pathway to ‘reprogram’ killer cells
The so-called natural killer (NK) cells are cells of the innate immune system that recognize and eliminate infected cells or cancer cells. During a virus infection, NK cells also keep the body’s own immune cells such as the T cells…