Tag: Simmons Cancer Center

Innovative surgery preserves limb growth for childhood bone cancer patients

sarah JonasFeature Expert

Arlette Chavez was a typical 3-year-old who loved jumping on the bed, riding her bike, and playing tag, said her mother, Lesly Rivera. When this active preschooler started complaining of pain in her left arm, Ms. Rivera and her husband, Carlos Chavez, weren’t overly concerned – it was probably a minor injury, they reasoned. But when an X-ray revealed a tumor on her left humerus, the bone that runs from the shoulder to the elbow, a biopsy soon confirmed that Arlette had a rare bone and soft tissue cancer called Ewing’s sarcoma. It is diagnosed in only about 200 children and teens each year in the U.S., according to the American Cancer Society.

Pathway tied to cancer-driving genome alterations identified

sarah JonasResearch Results

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.

UTSW’s Simmons Cancer Center awarded more than $11.5 million in CPRIT funding

sarah JonasAnnouncement

Eight scientists and physicians in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern have been awarded more than $11.5 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to support the state’s fight against cancer.

Widespread disparities exist in treating advanced cancers

sarah JonasResearch Results

A study led by researchers at UT Southwestern Medical Center reveals significant disparities across the country in the use of immunotherapy for patients with advanced kidney and bladder cancers.

Cancer cell–immune cell interactions predict immunotherapy response

sarah JonasResearch Results

By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.

Drug targeting clear cell renal cell carcinoma shows promising approach

sarah JonasResearch Results

In a groundbreaking phase one clinical trial led by UT Southwestern Medical Center, a short interfering RNA (siRNA) drug directed to tumor cells effectively disrupted HIF2α, a key driver of clear cell renal cell carcinoma (ccRCC). Published in Clinical Cancer Research, the findings illustrate the potential of siRNA for cancer therapy.

UTSW discovers protective ‘acid wall’ formed by cancer cells

sarah JonasResearch Results

Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

Nanoparticles developed at UTSW effectively fight tumors

sarah JonasResearch Results

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types. Their findings, published in Science Immunology, offer a new way to potentially harness the power of the body’s immune system against cancer.

Moncrief Cancer Institute debuts new Mobile Screening Clinic funded by Tarrant County

sarah JonasAnnouncement

Moncrief Cancer Institute debuted its new Mobile Screening Clinic prior to the Tarrant County Commissioners Court meeting today. The $1 million, 36-foot cancer screening clinic was funded by Tarrant County through a three-year, $9 million grant awarded to Moncrief Cancer Institute in 2022. Part of the federal funding Tarrant County received through the American Rescue Plan Act (ARPA), the grant enabled Moncrief to expand its comprehensive cancer screening program to more underserved residents in Tarrant County.

UTSW researcher receives NIH Director’s New Innovator Award

sarah JonasAnnouncement

Ravikanth Maddipati, M.D., Assistant Professor of Internal Medicine and in Children’s Medical Center Research Institute at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to support research investigating positional heterogeneity in cancer, or how tumors in the same organ can behave differently based on where they form.

UT Southwestern biochemist Zhijian ‘James’ Chen to receive prestigious Horwitz Prize

sarah JonasAnnouncement

Zhijian “James” Chen, Ph.D., Professor of Molecular Biology at UT Southwestern Medical Center, has been awarded the 2023 Louisa Gross Horwitz Prize in recognition of his groundbreaking work on innate immunity.

Most pancreatic cancer patients don’t get lifesaving surgery

sarah JonasResearch Results

Only 22% of Texas patients with early-stage pancreatic cancer received standard-of-care surgery to remove their tumors, researchers at UT Southwestern Medical Center report in a new study. The findings, published in the Journal of Surgical Oncology, are a call to action to improve treatment in the Lone Star State for this deadly disease, the authors say.

CRI’s Sean Morrison elected to European Molecular Biology Organization

sarah JonasAnnouncement

Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).

Some cervical cancer patients at higher risk for UTIs after radical hysterectomies

sarah JonasResearch Results

Women with early-stage cervical cancer had significantly higher chances of developing catheter-associated urinary tract infections (CAUTIs) after radical hysterectomies if they were smokers or used a catheter for more than seven days post-surgery, UT Southwestern Medical Center researchers found in a study.

UT Southwestern researchers discover mechanism responsible for genome rearrangements

sarah JonasResearch Results

The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells. However, this process often goes awry and may be responsible for a new class of chromosomal abnormalities found in cancers and congenital disorders, UT Southwestern Medical Center scientists report in a new study. The discovery, published in Nature, sheds light on how cancer cells rapidly evolve genomic changes that fuel their proliferation.

UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients

sarah JonasFeature

UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults. The trial will examine the effects of combining several chemotherapy agents with an immunotherapy drug in children with solid tumors that have recurred or shown no significant response after initial treatment.

Nearly 100% of UT Southwestern medical students match to residency programs nationally, across Texas

sarah JonasAnnouncement

Nearly 100% of UT Southwestern Medical School students matched to residency programs – well above the national average of 94% – including about half who matched to hospitals affiliated with U.S. News & World Report’s top 25 medical schools, including UT Southwestern. More than 100 matched to Texas programs.

Simmons Cancer Center investigators receive nearly $15 million in CPRIT funding

sarah JonasAnnouncement

Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.

Healthy gut bacteria can help fight cancer in other parts of the body, UTSW researchers find

sarah JonasResearch Results

Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs. The findings, published in Science Immunology, shed light on why antibiotics can weaken the effect of immunotherapies and could lead to new cancer treatments.

Response to hormone therapy predicts radiation resistance in ER+ breast cancer

sarah JonasResearch Results

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.

UT Southwestern researchers discover gene regulation mechanism

sarah JonasResearch Results

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.

Cooling brain tumor cells could make headway in glioblastoma, UTSW researcher finds

sarah JonasResearch Results

Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident. The findings, published in Science Advances, could lead to new treatments for this aggressive and deadly cancer.

Simmons Cancer Center investigators receive more than $17 million in CPRIT funding

sarah JonasAnnouncement

Fifteen scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern received more than $17 million in research funds in the latest round of grants awarded by the Cancer Prevention and Research Institute of Texas (CPRIT). The grants will be used to address scientific questions covering a wide range of cancer types and topics.

Same Difference: Predicting Divergent Paths of Genetically Identical Cells

sarah JonasResearch Results

DALLAS – Jan. 11, 2021 – A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually lead to more predictable responses to pharmaceutical treatments.

Researchers Uncover A Potential Treatment For an Aggressive Form of Lung Cancer

sarah JonasResearch Results

DALLAS – Jan. 5, 2021 – Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer (NSCLC). These findings could pave the way for new treatments for patients with mutations in two key genes – KRAS and LKB1. Patients whose tumors contain both of these mutations, known as KL tumors, have poor outcomes and usually do not respond to immunotherapy.

Errant DNA Boosts Immunotherapy Effectiveness

sarah JonasResearch Results

DALLAS – Dec. 17, 2020 – DNA that ends up where it doesn’t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in Cancer Cell, suggest that delivering radiation – which triggers DNA release from cells – before immunotherapy could be an effective way to fight cancers that are challenging to treat.