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UrduUsing a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.
Tag: Bruce Beutler
National Cancer Institute Renews Simmons Cancer Center’s Prestigious Comprehensive Designation
The National Cancer Institute has renewed the Harold C. Simmons Comprehensive Cancer Center’s comprehensive designation, reaffirming its place among the country’s elite cancer institutes.
Structural Biology Provides Long-Sought Solution to Innate Immunity Puzzle
UT Southwestern researchers report the first structural confirmation that endogenous – or self-made – molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4−MD-2 receptor complex. The work has wide-ranging implications for finding ways to treat and possibly prevent autoimmune diseases such as multiple sclerosis and antiphospholipid syndrome.
UT Southwestern Scientists Closing in on Map of The Mammalian Immune System
Using artificial intelligence, UT Southwestern scientists have identified thousands of genetic mutations likely to affect the immune system in mice. The work is part of one Nobel laureate’s quest to find virtually all such variations in mammals.