Digital Tools Effective for Reducing Drinking In People with Excessive Alcohol Use Who May Not Seek Formal Treatment, Study Suggests

In a large group of frequent drinkers who used a digital application offering tailored text-based support for reducing their alcohol intake, weekly drink amounts fell by 1/3 over 12 weeks. The study of real-world users shows promise for people who are uncomfortable with their drinking habits but may not meet the criteria for alcohol use disorder (AUD). Although they may be unlikely to aim for abstinence or to seek formal treatment, many are open to moderating their drinking. Digital interventions, such as self-guided online programs and smartphone apps, are easily accessible and engaging. Studies have shown that text-based messaging interventions can result in short- and medium-term reductions in alcohol use. Digital programs that tailor content according to users’ evolving outcomes, similar to clinical care, may be particularly effective. Outcomes data are limited, however. For the study in Alcohol: Clinical & Experimental Research, researchers evaluated an adaptive, tailored digital

Unveiling the Brain’s Reward Circuitry

A research team – co-led by Penn Nursing – has made a significant breakthrough in understanding the complex neural circuitry underlying reward and addiction by identifying 34 distinct subtypes of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a key brain region involved in pleasure and motivation. The findings, published in the journal Scientific Reports by Nature, offer insights into the diversity of these neurons and their potential roles in substance use disorders.

Exploring the underlying emotions that lead to alcohol and cannabis use

Theoretical models of alcohol and cannabis use disorders often focus on the idea that people consume alcohol and cannabis use to regulate their negative emotions – in other words, to make themselves feel better. New research does not support this idea, finding instead that people mostly consume alcohol and cannabis in their daily life when they are experiencing positive emotions.

Brain Imaging May Predict Motivation for Behavior Change in Alcohol Use Disorder

Brain imaging of neuron activity in certain areas of the brain may predict whether an individual is likely to successfully respond to interventions to reduce their drinking. In a study published in Alcohol: Clinical and Experimental Research, individuals whose baseline imaging showed decreased activity in areas of the brain associated with reward processing and impulsivity and increased activity in regions responsible for complex cognitive processes and emotional regulation were more likely to reduce their drinking following an intervention.

Emerging adults who experience pain and related anxiety may engage in high-risk drinking

Emerging adults – those aged 18 to 24 years –who experience pain are more likely to engage in high-risk patterns of alcohol use such as binge drinking. Anxiety caused by pain may be what motivates unhealthy coping strategies such as excessive drinking as a form of escape/avoidance. These results and others will be shared at the 46th annual scientific meeting of the Research Society on Alcohol (RSA) in Bellevue, Washington.

In Response to Stephen Colbert, FAU Professor Says ‘Spice it Up’

A research professor gives a “shout out” to comedian Stephen Colbert. His motivation? Colbert previously referred to mathematical equations as the devil’s sentences and an unnatural commingling of letters and numbers – the worst being the quadratic equation – an infernal salad of numbers, letters and symbols. In response, the professor suggests that mathematics education needs to be enlivened so that students will recognize that this discipline is not merely a necessary evil, but a vibrant, exciting and fascinating subject.

One size does not fit all for young-adult binge-drinkers: Research reveals high-risk clusters that may inform future trajectories and treatment interventions

Young adults who binge drink can be categorized within distinct subgroups based on substance use and mental health symptoms, according to research reported in Alcoholism: Clinical and Experimental Research. Binge drinking in young people is very common and linked to adverse outcomes including academic underachievement, risky behaviors, alcohol poisoning, other substance use, and harm to the brain. While some ‘age out’ of binge-drinking in their mid-to-late 20s, others continue with harmful patterns of alcohol use. Previous research has shown that other substance use and mental health indicators vary widely among binge-drinking youth, and could help explain the differences in trajectories. It is also important to understand young people’s motivation for drinking alcohol to inform why some people naturally reduce and others persist or worsen. In the new study, researchers sought to identify distinct patterns of drinking, drug use, and mental health symptoms among young binge drinkers, an

Lack of Motivation the Most Central Domain for Successful Treatment of Schizophrenia Symptoms

A recent conceptual development in schizophrenia is to view its manifestations as interactive networks rather than individual symptoms. Negative symptoms, which are associated with poor functional outcome and reduced rates of recovery, represent a critical need in schizophrenia therapeutics. MIN101…