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UrduThe researchers hope to one day target this T cell population via drug therapy. “These cells may be a very important target for treating ulcerative colitis and perhaps other autoimmune diseases…”
Tag: Autoimmunity
Study identifies new pathway to suppressing autoimmunity
Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.
COVID-19 and Type 1 Diabetes: Researchers Find an Increase in Islet Autoimmunity in Young Children Who Had a Sars-CoV-2 Infection
Type 1 diabetes is an autoimmune disease leading to an impaired glucose metabolism and requires life-long administration of insulin. While the cause of the autoimmunity reaction is still unclear, viral infections in young children are proposed to be critical environmental factors leading to type 1 diabetes.
Proteins Predict Significant Step Toward Development of Diabetes
Scientists have taken an important step forward in predicting who will develop Type 1 diabetes months before symptoms appear.
‘Tipping The Balance’ Of Immune Cells from Bad to Good Reverses Multiple Sclerosis Symptoms in Mice
According to the federal government’s National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide — with almost a third in the United States — are living with multiple sclerosis (MS), a disabling neurological disease in which the body’s immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.
nPOD honors Estefania Quesada Masachs for type 1 diabetes discoveries
La Jolla Institute for Immunology (LJI) Instructor Estefania Quesada Masachs, M.D., Ph.D., has won the 2023 Young Investigator of the Year Award from the Network for Pancreatic Organ donors with Diabetes (nPOD). This prestigious award recognizes Quesada Masachs’ groundbreaking research in type 1 diabetes.
CHOP-led Study Identifies Two Different Regulatory T Cell Populations
A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively.
New $17 million grant establishes LJI as global hub for immunology data curation and analysis
A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).
Harnessing good fats to relieve MS symptoms
Researchers find that fish oil derivative reduces and delays disease–causing inflammation in mouse model of multiple sclerosis
Boot Camp for the Immune System
Researchers identify new mechanism that teaches immune cells-in-training to spare the body’s own tissues while attacking pathogens.
Research Group Identifies Potential Therapeutic Target for Lupus
Inhibiting IRE1α, a molecule activated by the endoplasmic reticulum in neutrophils, counters disease progression in lupus mice.
Cancer Immunotherapy May Also Treat Certain Autoimmune Diseases
The new approach blocks the interaction between cancer cells and immune receptors, showing promise in mice.
A Novel Immunotherapy Proves Effective in Animal Models of Multiple Sclerosis
Jefferson researchers develop an approach to specifically impede the autoimmune response that drives the disease, while leaving the rest of the immune system fully functioning.
Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
Transplanting cadaver pancreatic islets is a promising therapy for Type 1 diabetes, but a reactivated autoimmunity means low graft viability after five years. Research now shows that a protective coating of two biopolymers can delay allograft and autoimmune-mediated rejection in mouse models of T1D.
Protein that Keeps Immune System from Freaking Out Could Form Basis for New Therapeutics
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction and supports a mechanism critical for survival in mouse models of sepsis and colitis, according to a UC San Diego study.
AARDA MOURNS THE LOSS OF DR. NOEL R. ROSE, “THE FATHER OF AUTOIMMUNITY”
AARDA Tribute to Dr. Noel R. Rose, “The Father of Autoimmunity”
New research gives further evidence that autoimmunity plays a role in Parkinson’s disease
A new study co-led by scientists at the La Jolla Institute for Immunology (LJI) adds increasing evidence that Parkinson’s disease is partly an autoimmune disease. In fact, the researchers report that signs of autoimmunity can appear in Parkinson’s disease patients years before their official diagnosis.