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UrduPelvic floor disorders (PFDs), which occur when women’s pelvic floor muscles are weakened or injured, significantly affect quality of life and require surgery for hundreds of thousands in the U.S. each year. Now a study led by UT Southwestern Medical Center researchers has found a noninvasive test that could identify women at risk for these conditions and improve treatment.
Tag: Ut Southwestern
CRI’s Sean Morrison elected to European Molecular Biology Organization
Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).
UT Southwestern toxicologist offers tips to keep food safe during summer grilling season
The arrival of summer marks the return of a cherished activity: backyard grilling. A UT Southwestern Medical Center toxicologist offers some cautionary guidelines to help you and your guests avoid food poisoning.
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern and Children’s Health
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three different rare diseases at UT Southwestern Medical Center and Children’s Health, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
Warfarin use should not disqualify stroke patients from lifesaving clot-removing surgery
Most stroke patients taking the anticoagulant warfarin were no more likely than those not on the medication to experience a brain bleed when undergoing a procedure to remove a blood clot, UT Southwestern Medical Center researchers report in a new study. The findings, published in JAMA, could help doctors better gauge the risk of endovascular thrombectomy (EVT), potentially expanding the pool of eligible patients for this mainstay stroke treatment.
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three rare diseases at UT Southwestern Medical Center, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
Noboro Mizushima, M.D., Ph.D., awarded inaugural Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern
Japanese biochemist and molecular biologist Noboru Mizushima, M.D., Ph.D., has been named the inaugural recipient of the Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern Medical Center. Dr. Mizushima is an internationally recognized scientist who has made significant strides in unraveling the complex processes of mammalian autophagy, a fundamental cellular mechanism responsible for maintaining cellular health and functionality.
Former UTSW Otolaryngology Chair recognized for pioneering cochlear implant contributions
Peter Roland, M.D., Professor Emeritus of Otolaryngology-Head and Neck Surgery at UT Southwestern Medical Center, has been honored by the American Cochlear Implant Alliance with its 2023 Lifetime Achievement Award for his groundbreaking work in advancing the use and benefits of cochlear implants (CI).
Start screenings at age 45 to prevent colorectal cancer, UT Southwestern experts advise
Colorectal cancer is on the rise among younger adults. According to the American Cancer Society, the proportion of cases among people under 55 increased from 11% in 1995 to 20% in 2019, and it is now the leading cause of cancer-related deaths for men younger than 50.
Mortality high for children whose caregivers decline tracheostomies, UTSW study shows
Forty percent of critically ill children whose parents or other caregivers declined tracheostomies died within 24 months, and half of all deaths occurred within six weeks, researchers at UT Southwestern Medical Center and Children’s Medical Center Dallas found.
New study sheds light on complex genetics of autism in East African families
UT Southwestern Medical Center researchers have identified hundreds of genomic variants associated with autism spectrum disorder (ASD) in East African families who have a markedly higher prevalence of the neurodevelopmental condition than other populations worldwide. The study, published in Cell Genomics, is the first to investigate the genetics of ASD in an African population, an important step toward decreasing racial and ethnic health disparities for this condition, the authors said.
Some cervical cancer patients at higher risk for UTIs after radical hysterectomies
Women with early-stage cervical cancer had significantly higher chances of developing catheter-associated urinary tract infections (CAUTIs) after radical hysterectomies if they were smokers or used a catheter for more than seven days post-surgery, UT Southwestern Medical Center researchers found in a study.
Antibodies associated with rare disorder may signal future risk of heart attack and stroke
Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern Medical Center scientists shows
UT Southwestern researchers discover mechanism responsible for genome rearrangements
The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells. However, this process often goes awry and may be responsible for a new class of chromosomal abnormalities found in cancers and congenital disorders, UT Southwestern Medical Center scientists report in a new study. The discovery, published in Nature, sheds light on how cancer cells rapidly evolve genomic changes that fuel their proliferation.
Poor sleep can lead to long-term health problems for older adults, UTSW specialists say
It’s a common misconception that older adults need less sleep than those younger, but many get fewer hours due to insomnia and various health problems, including sleep apnea and heart trouble. In addition to a reduced quality of life, long-term health consequences of poor sleep include high blood pressure, weight gain, stroke, heart attack, diabetes, memory problems, and even increased risk of death, said Deborah Freeland, M.D., Assistant Professor of Internal Medicine and a member of UTSW’s Division of Geriatric Medicine.
Racial disparities exist in use of statins to reduce heart disease risk, UTSW study shows
Black and Hispanic adults at risk of developing cardiovascular disease are less likely to take statin drugs than white adults with the same risk factors, UT Southwestern Medical Center researchers reported in JAMA Cardiology.
UT Southwestern Q&A: Experts offer tips on talking to kids about traumatic events
Following the latest mass shooting at an outlet mall in Allen, Texas, on Saturday and other violent incidents across the country, parents may find themselves trying to navigate difficult conversations with their children. What to say is just as important as what not to say, according to experts at UT Southwestern Medical Center. Children are naturally curious and may have questions, or they may be worried about their own safety.
UT Southwestern Medical Center at Coppell offers convenient adult and pediatric care in northwest Dallas region
UT Southwestern Medical Center is expanding its footprint to better serve the northwest Dallas region, offering primary care visits ranging from management of chronic health issues to women’s health exams at UT Southwestern Medical Center at Coppell.
UTSW researchers generate cattle blastoids in lab to aid farm animal reproduction
UT Southwestern Medical Center stem cell and developmental biologists and colleagues have developed a method to produce bovine blastoids, a crucial step in replicating embryo formation in the lab that could lead to the development of new reproductive technologies for cattle breeding.
Carlos Arteaga, M.D., named to Susan G. Komen® research scholar group
Carlos L. Arteaga, M.D., Director of the Harold C. Simmons Comprehensive Cancer Center and Associate Dean of Oncology Programs at UT Southwestern Medical Center, has been named a research scholar for Susan G. Komen®, one of the world’s leading breast cancer organizations.
UT Southwestern Physiology Chair, molecular geneticist elected to prestigious National Academy of Sciences
The National Academy of Sciences elected two more UT Southwestern Medical Center scientists in the fields of molecular genetics and physiology into its membership, one of the highest honors for American scientists. Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics, and Duojia Pan, Ph.D., Chair of Physiology and a Howard Hughes Medical Institute Investigator, were elected by their peers in recognition of the importance of their scientific discoveries.
Male, female knee cartilage disparities may explain differences in rates of degeneration
Researchers have long known there are sex disparities when it comes to the prevalence and severity of knee osteoarthritis, a disease that causes cartilage degeneration. Now, investigations underway at UT Southwestern Medical Center point to biological differences in the knee cartilage of male and female animals that could explain substantial variances in rates of osteoarthritis between the sexes and may eventually lead to tailored treatments that take these into account.
Cardiovascular risk, complications changed as pandemic progressed
The rate of heart attacks, strokes, and other cardiovascular complications increased among patients hospitalized with COVID-19 between March 2020 and December 2021, according to a new study led by UT Southwestern Medical Center researchers. The rise came even as patients hospitalized with the virus tended to be younger and less likely to have had cardiovascular disease (CVD) as the pandemic wore on.
UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients
UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults. The trial will examine the effects of combining several chemotherapy agents with an immunotherapy drug in children with solid tumors that have recurred or shown no significant response after initial treatment.
Skin conditions may indicate more serious rheumatic disease, UT Southwestern physician says
While rheumatic diseases typically affect the joints, muscles, or ligaments, the first signs of a problem may appear on the skin. A UT Southwestern physician who specializes in rheumatology says it’s essential to know what to look for.
Award-winning UT Southwestern/Parkland Health program improves health care for new mothers
Women with chronic hypertension and diabetes who were enrolled in an award-winning program for 12 months after childbirth were more likely to keep follow-up health care visits, which in turn led to improved care, according to initial findings of the program published in The Joint Commission Journal on Quality and Patient Safety.
UT Southwestern researchers discover critical protein for common bone growth disorder
A team led by UT Southwestern Medical Center researchers has discovered a protein that appears to be pivotal for traumatic heterotopic ossification (HO), a condition in which bone forms in muscles, tendons, and other soft tissues after traumatic injury or surgery. The findings, published in Science Advances, could yield new ways to prevent this common complication, the researchers say.
UT Southwestern nephrologist addresses National Kidney Foundation
Susan Hedayati, M.D., Director of Clinical and Population Health Research in Nephrology at UT Southwestern, has spent a career investigating the links between kidney disease and depression and developing methods to improve care from a patient-centric perspective for those with chronic kidney disease.
AI can spot early signs of Alzheimer’s in speech patterns, study shows
New technologies that can capture subtle changes in a patient’s voice may help physicians diagnose cognitive impairment and Alzheimer’s disease before symptoms begin to show, according to a UT Southwestern Medical Center researcher who led a study published in the Alzheimer’s Association publication Diagnosis, Assessment & Disease Monitoring.
UT Southwestern surgeon offers insight on elbow injuries among young baseball players
Spring marks the arrival of baseball, and with it the risk of elbow injuries among young players. Tears or ruptures of the ulnar collateral ligament (UCL) are the most common elbow injury among baseball players from youth leagues to the major leagues, especially pitchers. The most severe cases require reconstructive surgery, commonly known as Tommy John surgery.
Use of racially concordant educational video did not affect acceptance of heart implant devices among Black patients
Multiple studies have demonstrated that Black patients are significantly less likely than white patients to undergo invasive cardiovascular procedures. Prior research also has demonstrated substantial racial disparities in the use of implantable cardioverter-defibrillators (ICDs) that can be lifesaving for those at high risk for sudden cardiac death.
Awareness vital to improving Parkinson’s patients’ quality of life, UTSW neurologist says
About 1 million people in the United States have Parkinson’s disease, a progressive neurological disorder that ranks second to Alzheimer’s among the most common neurodegenerative diseases. While many tend to associate Parkinson’s with hand tremors, it can cause a broad range of symptoms, affecting both motor and nonmotor functions.
UT Southwestern researchers create model to assess post-tonsillectomy bleed rates
Researchers led by a team at UT Southwestern Medical Center have created a statistical model to identify standards for typical, high, or low rates of bleeding after pediatric tonsillectomies. The findings, published in JAMA Otolaryngology-Head & Neck Surgery, could help doctors and hospitals improve outcomes for the third-most common pediatric surgery in the U.S.
UT Southwestern Q&A: Experts offer tips on talking to kids about school shootings, other traumatic events
After a school shooting like the one that occurred in Nashville, parents may find themselves trying to navigate difficult conversations with their children. What to say is just as important as what not to say, according to experts at UT Southwestern Medical Center. Children are naturally curious and may have questions, or they may be worried about their own safety.
Patients prefer immediate access to medical test results online, even if it’s bad news
Patients overwhelmingly prefer to receive test results as soon as they are available on online medical portals, even if it means viewing the results prior to discussing them with their doctor, a new study co-led by researchers at UT Southwestern and Vanderbilt University medical centers reports.
Nearly 100% of UT Southwestern medical students match to residency programs nationally, across Texas
Nearly 100% of UT Southwestern Medical School students matched to residency programs – well above the national average of 94% – including about half who matched to hospitals affiliated with U.S. News & World Report’s top 25 medical schools, including UT Southwestern. More than 100 matched to Texas programs.
Simmons Cancer Center investigators receive nearly $15 million in CPRIT funding
Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.
UT Southwestern Medical Center announces the Beth Levine, M.D. Prize in Autophagy Research
UT Southwestern Medical Center has established the Beth Levine, M.D. Prize in Autophagy Research, an annual award and lecture for exceptional scientists who have made significant contributions to the field of autophagy.
Healthy gut bacteria can help fight cancer in other parts of the body, UTSW researchers find
Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs. The findings, published in Science Immunology, shed light on why antibiotics can weaken the effect of immunotherapies and could lead to new cancer treatments.
UT Southwestern scientists discover agent that reverses effects of intoxication
A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new study. The findings, published in Cell Metabolism, could lead to effective treatments for acute alcohol intoxication, which is responsible for about 1 million emergency room visits in the U.S. each year.
Response to hormone therapy predicts radiation resistance in ER+ breast cancer
How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.
UT Southwestern study: Cell membrane ‘blebs’ could hold new targets for anti-cancer drugs
Cell membrane protrusions called blebs that typically signify the end of life for healthy cells do the opposite for melanoma cells, activating processes in these cells that help them to survive and spread, a UT Southwestern study suggests.
Business consultant and investor Debra Hunter Johnson named Chair of UT Southwestern President’s Advisory Board
Business consultant, attorney, and investor Debra Hunter Johnson, founder of Reciprocity Consulting Group, will chair the UT Southwestern Medical Center President’s Advisory Board for the 2023-2025 term.
Autoantibody linked to rare disorder that destroys fat, UT Southwestern researchers find
Researchers at UT Southwestern Medical Center have discovered the first molecular biomarker for acquired generalized lipodystrophy (AGL), a rare disorder in which fat deposits are destroyed, causing patients to have dangerously low body fat, signs of accelerated aging, and severe metabolic diseases including diabetes and fatty liver.
Young pregnant adolescents at increased risk of preeclampsia, C-section, UTSW study shows
Young adolescents face different challenges in pregnancy compared with their older teenage peers and adults that are sometimes exacerbated by high rates of obesity, a new study by UT Southwestern researchers suggests. The findings, published in the American Journal of Obstetrics & Gynecology MFM, could highlight at-risk populations for targeted prevention efforts.
All that texting and scrolling leads to a rise in ‘tech neck’
Technology can be a pain in the neck, leading to what’s known as “tech neck,” chronic pain that results from prolonged use of mobile phones, tablets, and other electronic devices.
Potential genetic regulators of the heartbeat identified by UT Southwestern researchers
UT Southwestern Medical Center researchers have mapped gene control elements in specialized cardiac cells responsible for coordinating heartbeats. The findings of the genome exploration study, published in The Journal of Clinical Investigation, provide insight into how heartbeats are regulated and could impact diagnosis and risk prediction for a variety of common arrhythmias.
Screening teens for vaping history key to diagnosing lung disease during pandemic
The severity of a lung disease associated with e-cigarettes in teens decreased during the COVID-19 pandemic, but hospitalizations from the disease continued to mount, according to a study of more than three dozen patients by UT Southwestern researchers published in Pediatric Pulmonology.
UT Southwestern researchers discover gene regulation mechanism
UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.
Head trauma doesn’t predict memory problems in NFL retirees, UT Southwestern study shows
A study of retired professional football players by researchers at UT Southwestern Medical Center found that their cognitive abilities did not differ significantly from a control group of similarly aged men who did not play football, nor did those abilities show significant change over one to five years. The findings were published in Brain Injury.