Persons of nonbinary gender may desire lower-dose testosterone treatment than guidelines recommend

Among transgender and gender-diverse adults whose gender identity is nonbinary—not exclusively male or female—and who choose low-dose hormone treatment, most prefer to continue testosterone therapy at lower-than-recommended doses after at least six months of treatment, a new study finds. The study will be presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.

Study finds potentially treatable factors to improve symptoms in men stopping illicit steroids

Men who illicitly used steroids to boost muscle size and physical performance and have stopped in the past year have impaired sexual function compared with men currently using steroids, according to a study being presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.

A third of trans masculine individuals on testosterone ovulate

“Trans masculine people are people born female but do not identify as such, for example they feel male, gender fluid or non-binary. Our examination of their ovarian tissue shows that 33% of them show signs of recent ovulation, despite being on testosterone and no longer menstruating,” says Joyce Asseler, PhD candidate at Amsterdam UMC.

Desai Sethi Urology Institute Researcher Finds “Sneaky Testosterone” Might Signal Worse Outcomes for Men with Prostate Cancer

Findings from the newly published study in The Journal of Clinical Investigation suggest a large proportion of men have testosterone concentrations that are much higher in and around the prostate than traditional blood draws suggest. And this elevated exposure near the prostate increases the risk of poor outcomes after surgical removal of the prostate gland.

Hormone alters electric fish’s signal-canceling trick

New research shows that the hormone testosterone — which naturally triggers male electric fish to elongate the electric pulses they send out during the breeding season — also alters a system in the fish’s brain that enables the fish to ignore its own electric signals.

Excess Testosterone Can Lead to Increased Cardiovascular Risks in People with Polycystic Ovary Syndrome

Article title: Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome Authors: Tori Stone, Licy L. Yanes Cardozo, Toni N. Oluwatade, Cheryl A. Leone, Melanie Burgos, Faith Okifo, Lubna Pal, Jane F. Reckelhoff, Nina. S. Stachenfeld From…

Prompt testosterone treatment improves mental health of transgender, gender-diverse people

Receiving rapid access to testosterone therapy reduced feelings of gender dysphoria and led to a clinically significant reduction in depression as well as a 50% reduction in suicidality among transgender and gender diverse adults, according to research being presented Sunday at ENDO 2023, the Endocrine Society’s annual meeting in Chicago.

Study reveals how treatment-resistant prostate cancer provides its own hormonal fuel

A new study in mice, led by researchers at Washington University School of Medicine in St. Louis, explains how prostate cancer senses a drop in testosterone levels due to common anti-hormone therapy and then begins making cholesterol — a necessary precursor to testosterone — to generate its own testosterone to fuel tumor growth. The study also points to a possible drug combination that may stop the cancer from feeding its own growth.

Testosterone improves quality of life, sexual function, and delayed verbal recall in men with uncontrolled type 2 diabetes

Testosterone replacement therapy improved sexual symptoms, libido, symptom severity, delayed verbal recall and overall quality of life among people with poorly controlled type 2 diabetes and hypogonadism, according to research being presented Monday at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.

Analysis finds little evidence of heart problems in men undergoing testosterone treatment

Previous clinical trials have provided insufficient evidence to decide whether testosterone causes heart problems in men during the first year of treatment, according to research being presented Monday at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga., and published in The Lancet Healthy Longevity.

Inflammatory diet linked to testosterone deficiency in men

Consuming a diet high in pro-inflammatory foods – including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats – may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

Study finds oral testosterone therapy undecanoate is effective, with no liver toxicity

An industry-supported study of an oral testosterone replacement therapy (TRT), testosterone undecanoate (TU, brand name Jatenzo) finds it is an effective, long-term treatment for men with low testosterone levels, with no evidence of liver toxicity. The findings are being presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

Sex Hormones Contribute to Sex Differences in COVD-19

Article title: Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19? Authors: Rama Satyanarayana Raju Kalidhindi, Niyati A. Borkar, Nilesh Sudhakar Ambhore, Christina M. Pabelick, Y. S. Prakash, Venkatachalem Sathish From the authors:…

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Are testosterone-boosting supplements effective? Not likely, according to new research

Over-the-counter “T boosters” are a popular choice for men looking to raise their testosterone levels, and are frequently marketed as being an effective “natural” option. However, new research points toward these supplements as having little or no known effect. LOS…