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Researchers at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory are making progress on several fronts in the battle against COVID-19, the global pandemic sparked by the emergence of a novel coronavirus late last year. This work is part of a worldwide effort to understand the virus and the factors that affect its spread with the aim of devising treatments and other mitigation strategies.
Parkinson’s is a neurological disorder that progressively attacks motor functions, leading to lasting damage in movement and coordination. Researchers studying the primary causes of the disease have focused on mutations of the protein known as leucine-rich repeat kinase 2, or LRRK2.
Reducing the barriers preventing everyone from exploring the science behind biomolecular interactions and structures is the goal of molecular storytelling, a combination of visual and interactive methods used to explain the complex subject of structural biology. Through a 20-year partnership with the RCSB Protein Data Bank, researcher David Goodsell and a team of scientists have developed the Molecule of the Month series, which uses visual and interactive storytelling as an educational bridge for a wide audience of students, educators and the public.
Life on Earth manages to exist in the Mariana Trench and deep below the ocean floor, where extreme conditions create large effects on the behavior of biological molecules. At the Cornell High Energy Synchrotron Source, a facility dedicated to high-pressure biological X-ray scattering is available for use to explore those deep ocean molecules. Richard Gillilan will describe the main capabilities of BioSAXS and call for scientific use of the facility at the 70th Annual Meeting of the American Crystallographic Association.
UPTON, NY—On July 29, 2020 the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory opened a new cryo-electron microscopy center, the Laboratory for BioMolecular Structure (LBMS), with an initial focus on COVID-19-related research. This state-of-the-art research center for life sciences imaging offers researchers access to advanced cryo-electron microscopes (cryo-EM)—funded by NY State—for studying complex proteins, as well as the architecture of cells and tissues.
A team of scientists led by Abhishek Singharoy at Arizona State University used the Summit supercomputer at the Oak Ridge Leadership Computing Facility to simulate the structure of a possible drug target for the bacterium that causes rabbit fever.
A team of researchers has used ultra-bright X-rays to analyze 13,000-year-old fossilized beetle wings to learn more about the evolution of structural colors.
Researchers designed a nanodevice with the potential to prevent peptides from forming dangerous plaques in the brain in order to halt development of Alzheimer’s disease.
Two researchers at Memorial Sloan Kettering Cancer Center’s (MSK) Sloan Kettering Institute (SKI) have been elected to the National Academy of Sciences (NAS). Scott Keeney, PhD, a molecular biologist, and Christopher Lima, PhD, a structural biologist, join more than a dozen MSK investigators who are already NAS members. SKI is the research enterprise of MSK, the world’s oldest and largest private cancer center. Members are elected in recognition of their distinguished and continuing achievements in original research. Membership is one of the highest honors bestowed upon scientists worldwide.
The lab is responding to the coronavirus crisis by imaging disease-related biomolecules, developing standards for reliable coronavirus testing and enabling other essential research.
Argonne scientists are working around the clock to analyze the virus to find new treatments and cures, predict how it will propagate through the population, and make sure that our supply chains remain intact.
A potential drug target has been identified in a newly mapped protein of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). The structure was solved by a team including the University of Chicago (U of C), the U.S. Department of Energy’s (DOE) Argonne National Laboratory, Northwestern University Feinberg School of Medicine and the University of California, Riverside School of Medicine (UCR).
Weizmann Institute scientists created a decoy molecule that successfully recruits the immune system to fight arenaviruses. It also appears to be heat-resistant and stable, meaning it could be delivered to the remote areas where these diseases are endemic.
Scientists using specialized beamlines at Argonne’s Structural Biology Center (SBC), a facility for macromolecular crystallography at the Advanced Photon Source, derived insights that led to the discovery of a promising new drug for Ebola.
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