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UrduNearly 11 percent of people admitted to an intensive care unit in Sweden between 2010 and 2018 received opioid prescriptions on a regular basis for at least six months and up to two years after discharge. That is according to…
Tag: PHARMACEUTICAL CHEMISTRY
The Lancet: Study reports preliminary efficacy and safety results from interim analysis of Russian COVID-19 phase 3 vaccine trial
Interim analysis from phase 3 trial of nearly 20,000 participants suggests efficacy of two-dose regimen of the adenovirus-based vaccine is 91.6% against symptomatic COVID-19 – trial reports 16 COVID-19 cases in the vaccine group (0.1% [16/14,964) and 62 cases (1.3%…
Basics of chemical analysis
Technological developments involves all aspects of life, especially the fields of science, engineering, and medicine. This reflects in the students and researcher a lack of using traditional methods to learn the basics of each science. One of the conventional techniques…
Computer model makes strides in search for COVID-19 treatments
Framework helps find drug repurposing candidates for new diseases
Common HIV drugs may prevent leading cause of vision loss, study finds
Scientists have identified a group of drugs that may help stop a leading cause of vision loss after making an unexpected discovery that overturns a fundamental belief about DNA. The drugs, known as Nucleoside Reverse Transcriptase Inhibitors, or NRTIs, are…
Update on cancer etiology and therapeutic advancement
Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of…
Enhanced Recovery Efforts for Cesarean Delivery Reduce Need for Opioids by 80%
Results of study by Children’s Hospital Colorado show a third of patients not needing narcotic pain pills after c-section
Bentham Science announces the launch of journal, ‘Current Probiotics’
Bentham Science announces the launch of the subscription-based journal, Current Probiotics . The first issue of the journal will be available online in the year 2021. Dr. E.L. de Souza is the Editor-in-Chief of this new journal. Dr. E.L. de…
Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19
What The Study Did: This randomized clinical trial compares the effects of three doses of bamlanivimab monotherapy (700 vs 2,800 vs 7,000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus…
New antifungal compound from ant farms
Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though…
Single-cell test can reveal precisely how drugs kill cancer cells
Cancer cells are smart when it comes to anti-cancer drugs, evolving and becoming resistant to even the strongest chemotherapies over time. To combat this evasive behavior, researchers have developed a method named D 2 O-probed CANcer Susceptibility Test Ramanometry (D…
Çukurova University (TDRAC) joins Bentham Science as institutional member
Bentham Science is pleased to announce an Institutional Member partnership with the Turkish university, Çukurova University Tropical Diseases Research and Application Center (TDRAC). The partnership provides the opportunity to the researchers, from the university, to publish their research under an…
IOF and IFCC review calls for harmonization of assays for reference bone turnover markers
New review describes the current status of assays for PINP and β-CTX in blood, as well as the plans for and progress towards the achievement of harmonization or standardization of commercial assays for these reference markers
Compound from medicinal herb kills brain-eating amoebae in lab studies
Primary amoebic meningoencephalitis (PAM), a deadly disease caused by the “brain-eating amoeba” Naegleria fowleri , is becoming more common in some areas of the world, and it has no effective treatment. Now, researchers reporting in ACS Chemical Neuroscience have found…
Synthesis of biologically active compounds
Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for…
Acta Pharmaceutica Sinica B volume 10, issue 11 publishes
Special Issue: Tumor Microenvironment and Drug Delivery Guest Editors: Huile Gao, West China School of Pharmacy, Sichuan University, Chengdu, China; Zhiqing Pang, Fudan University, Shanghai, China and Wei He, China Pharmaceutical University, Nanjing, China The Journal of the Institute of…
Acta Pharmaceutica Sinica B volume 10, issue 12 publishes
The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high…
Single-dose COVID-19 vaccine triggers antibody response in mice
Across the world, health care workers and high-risk groups are beginning to receive COVID-19 vaccines, offering hope for a return to normalcy amidst the pandemic. However, the vaccines authorized for emergency use in the U.S. require two doses to be…
Botulism breakthrough? Taming botulinum toxin to deliver therapeutics
Treatment reverses paralysis in mice; offers a general delivery platform for neurologic drugs
Biologist collaborates on computational modeling tools to predict efficacy of cancer drugs
Project to model cancer pathways supported through $1.4 million renewal grant from the National Institutes of Health
Drug discovery study identifies promising new compound to open constricted airways
University of South Florida experts in airway bitter taste receptors and medicinal chemistry team up to advance a potential asthma and COPD treatment that works differently than existing bronchodilators
LSU Health New Orleans discovers potential new RX strategy for stroke
New Orleans, LA – Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke…
ACP, Annals of Internal Medicine host virtual COVID-19 Vaccine Forum II for physicians
Panel offers timely, evidence-based advice for promoting vaccine confidence and uptake
Filled buprenorphine prescriptions for opioid use disorder during COVID-19 pandemic
What The Study Did: The COVID-19 pandemic has disrupted health care delivery in the United State, and researchers in this study examined changes in total U.S. retail pharmacy sales and sales of buprenorphine products with a U.S. Food and Drug Administration-approved…
Blood pressure drug may be key to increasing lifespan, new study shows
Metolazone, a drug used to treat hypertension, activates a mitochondrial stress response that prolongs lifespan in the roundworm Caenorhabditis elegans
Antifungal drug improves key cystic fibrosis biomarkers in clinical study
CHAMPAIGN, Ill. — A drug widely used to treat fungal infections improved key biomarkers in lung tissue cultures as well as in the noses of patients with cystic fibrosis, a clinical study by researchers at the University of Illinois Urbana-Champaign…
Two tough fungi discovered in Denmark: Devour flies from within
BIODIVERSITY University of Copenhagen researchers have found and described two fungal species for the first time. The fungi infect adult flies and subsequently create a hole in the abdomen of their hosts’ bodies. Infected flies then buzz around days as…
Treatment of opioid use disorder among commercially insured patients in context of COVID-19 pandemic
What The Study Did: Opioid use disorder treatment during the early months of the COVID-19 pandemic, including medication fills, outpatient visits and urine tests among privately insured individuals, was compared with 2019 in this study. Authors: Haiden A. Huskamp, Ph.D.,…
Mail-order medications often exposed to unsafe temperatures, study shows
Drug effectiveness could be impacted by storage and transit conditions
Researchers call for clarity on the definition of medicine misuse
Medicine misuse is a public health issue, but the term has different meanings to people in different settings. A recent analysis of published studies provides a comprehensive overview of the terms and definitions used to characterize medicine misuse. The findings…
Using light, red blood cells and a honey bee peptide to deliver therapeutic proteins
Protein therapies are often more potent and selective toward their biochemical targets than other types of drugs, particularly small molecules. However, proteins are also more likely to be quickly degraded by enzymes or cleared from blood by the kidneys, which…
An eventful year in pharma
As 2020 draws to a close, the global pandemic has cast an even brighter spotlight on the pharmaceutical industry. Experts have spent the year racing to develop tests, therapeutics and vaccines to diagnose and combat COVID-19, while also trying to…
Researchers identify an action mechanism for a drug against Alzheimer’ disease
Late-onset Alzheimer’s disease murine model
New compound related to psychedelic ibogaine could treat addiction, depression
A non-hallucinogenic version of the psychedelic drug ibogaine, with potential for treating addiction, depression and other psychiatric disorders, has been developed by researchers at the University of California, Davis. A paper describing the work is published Dec. 9 in Nature…
Ability to predict C-diff mortality nearly doubled with new guidelines
University of Houston team assesses change to severity definitions
Vitamin boosts essential synthetic chemistry
Rice lab discovers light-driven catalyst forms olefins for drug, agrochemical manufacturing
Shining a light on the weird world of dihydrogen phosphate anions
Scientists at UNSW Sydney, together with collaborators from Western Sydney University and The Netherlands, were surprised to find that dihydrogen phosphate anions – vital inorganic ions for cellular activity – bind with other dihydrogen phosphate anions despite being negatively charged.…
TTUHSC’s Sutton receives grant to continue work on potential lupus treatment
The Lupus Research Alliance (LRA) recently named R. Bryan Sutton, Ph.D., a professor in the Department of Cell Physiology and Molecular Biophysics at the Texas Tech University Health Sciences Center (TTUHSC), as a recipient of a 2020 Lupus Mechanisms and…
Artificial intelligence collaboration seeking to hasten COVID-19 insights
WEST LAFAYETTE, Ind. – During the COVID-19 pandemic, health care professionals and researchers have been confined mostly to using local and national datasets to study the impact of comorbidities, pre-existing medication use, demographics and various interventions on disease course. Now,…
Environmental exposures affect therapeutic drugs
High-resolution mass spectrometry promotes new methods for analysis
Understanding frustration could lead to better drugs
Rice scientists’ atomic resolution protein models reveal new details about protein binding
New €25.5 million European project to accelerate development of ATMPs
The field of Advanced Therapy Medicinal Products research, which includes gene and cell therapies, is expected to grow exponentially in the coming years, with potentially up to 10-20 new drug applications submitted per year to the FDA by 2025 The…
Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology , that addresses the gap in the discovery of new antibiotics.…
Machine learning innovation to develop chemical library
One-step multicomponent reaction with interpretable machine learning innovation to develop chemical library for drug discovery
A DNA-based nanogel for targeted chemotherapy
Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers reporting in ACS’ Nano Letters have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within…
Alzheimer’s disease drug may help fight against antibiotic resistance
An experimental Alzheimer’s disease treatment is proving effective at treating some of the most persistent, life-threatening antibiotic-resistant bacteria. Researchers from The University of Queensland, The University of Melbourne and Griffith University have discovered that the drug called PBT2 is effective…
Genetic code evolution and Darwin’s evolution theory should consider DNA an ‘energy code’
‘Survival of the fittest’ phenomenon is only part of the evolution equation
New molecules derived from cannabidiol are designed with more potent antioxidants
Nowadays, cannabidiol is a star component, not only in the world of cosmetics, but also in pharmaceutics and nutrition due to its antioxidant properties and its therapeutical potential. It is a natural molecule that comes from medicinal cannabis and that,…
Worms reveal why melatonin promotes sleep
Research in C. elegans shows how melatonin activates the BK channel in the brain
A therapeutic option for glioblastoma using pH-sensitive nanomicelles
Summary: Using practical nano-DDS technology, a polymeric nanomicelle that effectively delivers the potent mitotic inhibitor desacetyl vinblastine hydrazide (DAVBNH) to glioblastoma (GBM) was developed. GBM, which grows rapidly under anaerobic conditions, causes acidosis due to enhanced glycolysis, and the developed…