English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduWEST LAFAYETTE, Ind. – A new treatment option for lung fibrosis is being developed by Purdue University scientists. Lung fibrosis has been a concern for COVID-19 patients. People with idiopathic pulmonary fibrosis (IPF) have a life expectancy of less than…
Tag: PHARMACEUTICAL CHEMISTRY
CrystEngComm celebrates the CSD in a special issue
The issue contains 33 papers highlighting the breadth of research made possible with this data
Aviara Pharmaceuticals, Inc receives grant to collaborate with the Texas Heart Institute
Texas Collaboration to Develop Treatment for Inflammatory Disease
Personalized cancer vaccine clinical trial to expand following promising early results
A study led by University of Arizona Health Sciences researcher Dr. Julie Bauman that’s investigating a personalized cancer vaccine has reported a 50% response rate for patients with head and neck cancer in its preliminary data
New research supports clinical utility of CTC count for metastatic breast cancer
First randomized clinical trial demonstrating that Circulating Tumor Cell count may help personalize treatment choices
Effect of hydroxychloroquine on clinical status
What The Study Did: This randomized trial compares the effects of hydroxychloroquine versus placebo on patients’ clinical status at 14 days (home, requiring noninvasive or invasive ventilation or extracorporeal membrane oxygenation, hospitalized, died) among adults hospitalized with COVID-19. Authors: Wesley…
USask launches first study on effects of smoked cannabis on brain development
SASKATOON – University of Saskatchewan (USask) pharmacologist Robert Laprairie will use a Brain Canada research grant to determine how a mother’s use of cannabis during pregnancy affects the brain of the developing fetus she’s carrying. Laprairie is one of 20…
Study reveals strategy to create COVID-19 drugs to inhibit virus’s entry and replication
University of South Florida Health-University of Arizona team reports compounds simultaneously targeting Mpro and cathepsin L may improve treatment of COVID-19 infection
Researchers show how to target a shape-shifting protein in Alzheimer’s disease
A new study suggests that it is possible to design drugs that can target a type of shape-shifting protein involved in Alzheimer’s disease, which was previously thought to be undruggable. A team of researchers, led by the University of Cambridge,…
Combining Eastern medicine with Western to improve cancer therapy
Can ancient Chinese herbs cure chemotherapy-related diarrhea?
Being in treatment with statins reduces COVID-19 mortality by 22% to 25%
This drug is currently taken by one in four people to reduce cholesterol in the blood and thus prevent cardiovascular diseases
Vitamin E from palm oil useful in boosting immune response based on studies on liver cells
The article by Dr. Ahmed Atia and colleagues is published in Current Pharmaceutical Biotechnology, 2020
Unravelling the origins of autoimmune psychosis
A first step towards potential treatments
Tube-dwelling anemone toxins have pharmacological potential, mapping study shows
Analysis identified 525 genes encoding proteins that act on the nervous system, cardiovascular system and cell walls. One of the molecules proved effective against cancer cells in preliminary test results
An artificial cell on a chip
Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with the desired properties. This “cell on a chip” is useful…
Antiseizure medication in pregnancy associated with twice the risk of autism in child
Study finds medication also associated with increased risk of ADHD
Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology . The analysis included 20,046,11,719 and…
Examining association between early treatment with tocilizumab, risk of death among critically ill COVID-19 patients
What The Study Did: Whether treatment with tocilizumab in the first two days after being admitted to an intensive care unit was associated with a reduced risk of death among critically ill patients with COVID-19 was investigated in this study.…
Tocilizumab vs standard care on preventing worsening in patients hospitalized with COVID-19 pneumonia
What The Study Did: Researchers in this randomized clinical trial compared the effect of early administration of tocilizumab with standard therapy in preventing clinical worsening in patients hospitalized with COVID-19 pneumonia. Authors: Carlo Salvarani, M.D., of Unita Operativa di Reumatologia…
A new strategy for siRNA stabilization by an artificial cationic oligosaccharide
RNA interference is a gene regulatory mechanism in which the expression of specific genes is downregulated by endogenous microRNAs or by small interfering RNAs (siRNAs). Although siRNAs have broad potential for gene-silencing therapy, their instability is one of the difficulties…
Examining CBD use for conditions with proven therapies
What The Study Did: Testimonials posted on a social media site were analyzed to examine whether individuals are using the cannabis-derived chemical compound cannabidiol (CBD) in an attempt to treat diagnosable conditions that have evidence-based therapies. Authors: John W. Ayers,…
Study reveals most effective drugs for common type of neuropathic pain
Clinical study tested four different types of medications for efficacy, tolerability and adverse effects
Machine learning model helps characterize compounds for drug discovery
WEST LAFAYETTE, Ind. – Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields. Now, Purdue University innovators have created a new method of applying machine learning concepts to the tandem…
Design and test potential COVID-19 treatments from your phone
The ViDok app crowdsources the drug discovery process
FDA support for oncology drug development during COVID-19
What The Study Did: This Viewpoint from the U.S. Food and Drug Administration puts into context recent guidance on clinical trials during COVID-19 for oncology and shares insight regarding regulatory challenges and lessons learned. Authors: Anand Shah, M.D., of the…
NIH award to fund UArizona research on opioid addiction and relapse in postpartum women
The $2.3 million National Institutes of Health grant enables University of Arizona College of Medicine Tucson’s Dr. Alicia Allen to explore how women’s hormones influence postpartum opioid relapse and if they can be used as a preventative strategy
CU Anschutz announces unique technology to rapidly screen new drugs, therapies
Potential to cut screening time by half, CU Anschutz first academic institution in Mountain West to have this technology
Novel testing platform designed for breast cancer cells
WEST LAFAYETTE, Ind. – A Purdue University team has developed a novel testing platform to evaluate how breast cancer cells respond to the recurrent stretching that occurs in the lungs during breathing. The technology is designed to better understand the…
Salk physician-scientist Edward Stites receives NIH Director’s New Innovator Award
LA JOLLA–(October 6, 2020) Salk Institute Assistant Professor Edward Stites has been named an NIH Director’s New Innovator for 2020 as part of the National Institutes of Health’s High-Risk, High-Reward Research Program. The award “supports unusually innovative research from early…
New techniques probe vital and elusive proteins
The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential for life. When proteins…
Deep learning gives drug design a boost
Rice translator expands metabolite prediction of chemical reactions in the human body
Global Pharmaceutical Policy
The only text available today which provides an up to date account of international pharmaceutical policy research.
Research shows cell perturbation system could have medical applications
Nanofountain Probe Electroporation system may lead to quicker and more customized treatment plans
Planaria flatworms can be alternative screening tool to avoid rabbit skin testing
Tests for skin treatments could be screened using flatworms rather than other animals such as rabbits, according to new research. A team at the University of Reading and Newcastle University have found that planaria, a type of flatworm, can be…
Pain relief caused by SARS-CoV-2 infection may help explain COVID-19 spread
SARS-CoV-2, the virus that causes COVID-19, can relieve pain, according to a new study by University of Arizona Health Sciences researchers. The finding may explain why nearly half of people who get COVID-19 experience few or no symptoms, even though…
A single-application treatment for ear infections that doesn’t need refrigeration
Outer ear infections, which affect millions of people each year, are typically caused by the bacteria Pseudomonas aeruginosa or Staphylococcus aureus . Repeatedly administering antibiotic drops, the standard treatment, can be a problem for some people, and the only single-use…
Breast cancer medication risk
Beta-blockers linked to lower survival in some patients
Cannabis data lacking, but machine learning could help
A new study shows we know little about compounds in marijuana, and names don’t mean much
Cancer’s hidden vulnerabilities
One of the biggest challenges to the development of medical treatments for cancer is the fact that there is no single kind of cancer. Cancers derive from many kinds of cells and tissues, and each have their own characteristics, behaviors,…
Fungal compound inhibits important group of proteins
Zebrafish embryos elucidate unknown effect for cercosporamide
Ultrapotent compound may help treat C. diff, reduce recurrence
WEST LAFAYETTE, Ind. – Clostridioides difficile, or C. diff, is the leading cause of health care-associated infection in the U.S. Only two antibiotics, vancomycin and fidaxomicin, are FDA approved for the treatment of C. diff, but even these therapies suffer…
Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine
As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it’s now more important than ever to have a thorough assessment of the safety of these medications. A recent…
Reactions and applications of Perhalopyridines
Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods. Substituted pyridine compounds are used generally as starting materials in the nucleophilic substitution reactions and have unique scaffolds for the construction of other…
New drug candidate found for hand, foot and mouth disease
Targeting RNA with small molecules could pave the way for new antivirals
Study on the effect of rosemary and ginger essential oils against Klebsiella pneumoniae
The article by Dr. Rania Abozahra and colleagues is published in The Open Microbiology Journal, Volume 14, 2020
Technique permits convenient, precise optical imaging of individual proteins
Often considered the workhorses of the body, proteins are among the most important biomolecules critical to life processes. They provide structural foundation for cells and tissues and perform a dizzying array of tasks, from metabolizing energy and helping cells communicate…
New insights into how the drug pomalidomide fights cancer
Multiple myeloma is a cancer of the white blood cells, and patients diagnosed with this disease commonly die within 5 years. Clinicians often treat multiple myeloma with the drug thalidomide and structurally similar drugs, such as lenalidomide and pomalidomide. Pomalidomide…
Study finds novel mechanism that may confer protection against glaucoma
New Orleans, LA – A team of researchers from LSU Health New Orleans Neuroscience Center of Excellence and the University of Copenhagen provides the first evidence that patients with ocular hypertension may exhibit superior antioxidant protection that promotes resistance to…
Scientists updated genome editing technology
Researchers compared their developed carriers for delivery of genome editing (GE) tools with other available analogues.
Parkinson’s patient skin samples provide clues to disease mechanism and clinical test
In a recently published study, researchers from the Turku Bioscience Centre at the University of Turku and Åbo Akademi University in Finland monitored the production of new proteins as they were produced by the cells’ protein building machinery, the ribosome.…