New study gives the most detailed look yet at the neuroscience of placebo effects

A large proportion of the benefit that a person gets from taking a real drug or receiving a treatment to alleviate pain is due to an individual’s mindset, not to the drug itself. Understanding the neural mechanisms driving this placebo…

Research agreement focuses on battlefield injuries

WEST LAFAYETTE, Ind. – OYE Therapeutics Inc., a Purdue University-affiliated company, is working to reduce the mortality and morbidity resulting from injuries on the battlefield through the development of new life-saving strategies. OYE is located in the Purdue Technology Center…

Study shows opioid use among US patients with knee osteoarthritis costs 14 billion dollars in societal costs

Although guidelines do not recommend use of opioids to manage pain for individuals with knee osteoarthritis, a recent study published early online in Arthritis Care & Research , an official journal of the American College of Rheumatology and the Association…

Treating rheumatoid arthritis with micromotors

Rheumatoid arthritis is a chronic inflammatory disorder marked by joint pain, swelling and damage. Although medications, such as steroids, anti-inflammatory drugs and immunosuppressants, can help slow joint destruction and relieve pain, they have side effects and aren’t completely successful. Now,…

Microneedle patches for microdosing psychedelic pharmaceuticals

(LOS ANGELES) – Although one may think of psychedelic pharmaceuticals as being dangerous and detrimental, scientists have been conducting experiments and clinical trials on some of them and have obtained positive results when testing them for medical use. Research has…

Good sleep is just what doctor ordered

In a study released Feb. 22 in JAMA Internal Medicine researchers found that six 20-minute telephone calls over eight weeks coaching participants on how to get better sleep improved their sleep, pain, and daytime function. The improvements in sleep and daytime function persisted 12 months after treatment. One of the lead investigators who has been researching age and sleeping for 40 years offers great tips on getting better sleep. Just because you are aging, does NOT mean your sleep needs to get worse.

Physical conditions linked to psychological distress in patients with cancer

Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. The analysis included 484 patients…

Radioactive bone cement found to be safer in treating spinal tumors

Irvine, Calif., Feb. 16, 2021 — A radioactive bone cement that’s injected into bone to provide support and local irradiation is proving to be a safer alternative to conventional radiation therapy for bone tumors, according to a study led by University of California, Irvine researchers. The study shows that this brachytherapy cement can be placed into spinal bones to directly irradiate tumors without harming the spinal cord, and the radioactive material will stay localized in the bones, which promises to virtually eliminate side effects.

Lipid epoxides target pain, inflammatory pathways in neurons

CHAMPAIGN, Ill. — When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called…

Kessler Foundation awarded three grants for spinal cord injury research studies

Craig H. Neilsen Foundation ensures ongoing support for studies delayed by effects of pandemic. Funding provided for research addressing environmental barriers, chronic pain and racial disparities that affect individuals with spinal cord injury

Opioid prescriptions remained elevated two years after critical care

Nearly 11 percent of people admitted to an intensive care unit in Sweden between 2010 and 2018 received opioid prescriptions on a regular basis for at least six months and up to two years after discharge. That is according to…

Nutrition, companionship reduce pain in mice with sickle cell disease, UCI-led study finds

Irvine, Calif., Feb. 1, 2021 — Researchers from the University of California, Irvine and the University of Minnesota have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin. They also discovered that duloxetine, an antidepressant that boosts serotonin levels, could be an alternative to opioids in treating chronic pain.