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UrduIn what they believe is a solution to a 30-year biological mystery, neuroscientists at Johns Hopkins Medicine say they have used genetically engineered mice to address how one mutation in the gene for the light-sensing protein rhodopsin results in congenital stationary night blindness.
Tag: mice
Using Advanced Genetic Techniques, Scientists Create Mice With Traits of Tourette Disorder
In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder. As reported in the Proceedings of the National Academy of Sciences, the researchers, using a technique known as CRISPR/Cas9 DNA editing, inserted the same genetic mutations found in humans with Tourette disorder into the corresponding genes in mouse embryos.
How Obesity Impacts Kidney Tubules in Mice
Rockville, Md. (April 17, 2024)—The lipids in kidney tubular segments (used to carry filtered nutrients to and from the blood) are unknown. In this study, researchers identified, counted and compared more than 500 types of fats. Significant compositional differences were…
Study in mice shows how chronic caffeine consumption alters sleep pattern and blood flow
Mice that consumed caffeine when awake slept more solidly and their overall amount of non-REM and REM sleep was not changed because they “slept in” later.
Getting ready for bed controlled by specific brain wiring in mice
The team, led by Imperial College London researchers, uncovered the wiring in mouse brains that leads them to begin nesting in preparation for sleep. Published today in Nature Neuroscience, the study reveals that preparing properly for sleep is likely a hard-wired survival feature – one often neglected or overridden by humans.
Engineered compound shows promise in preventing bone loss in space
Mice treated aboard the International Space Station showed significantly reduced bone loss
Researchers Highlight Challenges of Studying Mice, from Noise to Facility Changes
Article title: Analysis of a genetic region affecting mouse body weight Authors: Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee From the authors: “The studies conducted in…
High fat diet activates early inflammation in mouse brains, supports link to neurologic disease
Researchers at Michigan Medicine have discovered that a high-fat diet promotes an early inflammatory response in the brains of mice through an immune pathway linked to diabetes and neurologic diseases, suggesting a possible bridge between metabolic dysfunction and cognitive impairment.
Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice
As the third-most lethal cancer in the United States, with only a 1% five-year survival rate for people with its most aggressive form, pancreatic cancer has long been a target of researchers who search for ways to slow or stop its growth and spread. Now, a team of Johns Hopkins Medicine researchers have found that an anti-parasitic drug prevents pancreatic cancer’s initiation, progression and metastasis in genetically engineered mice.
Geographic differences in gut microbiota boost immunity
Gut reaction: Cornell researchers “humanized” mice with microbiota from three global populations and found that microbial differences alone can impact immune responses.
How Calcium Precisely Directs Blood Flow in the Brain
University of Maryland School of Medicine and University of Vermont researchers have shown how the brain communicates to blood vessels when in need of energy, and how these blood vessels respond by relaxing or constricting to direct blood flow to specific brain regions.
Lowering Iron in Fat Cells Prevented Weight Gain in Mice
DALLAS – June 28, 2021 – Lowering iron content in fat cells prevented mice fed a high-fat diet from gaining excess weight and developing associated health problems by limiting the amount of lipids absorbed by the intestines, UT Southwestern scientists report in a new study. The findings, published online in Cell Metabolism, could eventually lead to new strategies to protect people against obesity and related diseases.
Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
Dopamine Surge Reveals How Even for Mice, ‘There’s No Place Like Home’
“There’s no place like home,” has its roots deep in the brain. Using fiber photometry, scientists are the first to show that home evokes a surge of dopamine in mice that mimics the response to a dose of cocaine. The study demonstrates how dopamine rises rapidly in mice moved from a simple recording chamber to their home cage, but less so when they return to a cage not quite like the one they knew.
Agricultural Toxicity, Hepatic Effects of Phenobarbital, and More Featured in October 2020 Toxicological Sciences
Toxicological Sciences features leading research biotransformation, toxicokinetics, and pharmacokinetics; computational toxicology and databases; mixtures toxicology; and more in the October 2020 issue.
T Cell Therapy, Gut Microbiome, Tumorigenicity, and More Featured in September 2020 Toxicological Sciences
Toxicological Sciences features leading research in toxicology in the areas of biomarkers, environmental toxicology, and more in the September 2020 issue.