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UrduScientists characterize previously unknown gut reactions
Tag: METABOLISM/METABOLIC DISEASES
Study: Sleep apnea treatment reduces heart problems in patients with prediabetes
Research finds people with prediabetes and obstructive sleep apnea can reduce their daytime resting heart rate and risk of cardiovascular disease by using a CPAP device
Variation among states in hypertensive disorders of pregnancy
What The Study Did: Researchers examined variation among states in how common high blood pressure disorders of pregnancy (including pregnancy-induced hypertension or pre-eclampsia) and eclampsia were among 3.6 million women who had a live birth in 2017. Authors: Alexander J.…
Modifiable health risks linked to more than $730 billion in US health care costs
University of Washington and Vitality study found that 27% of US personal health care expenses were attributable to risk factors like obesity and smoking
Rapeseed instead of soy burgers: researchers identify a new source of protein for humans
Rapeseed has the potential to replace soy as the best plant-based source of protein for humans. In a current study, nutrition scientists at the Martin Luther University Halle-Wittenberg (MLU), found that rapeseed protein consumption has comparable beneficial effects on human…
NIH funds first nationwide network to study rare forms of diabetes
A nationwide study funded by the National Institutes of Health will seek to discover the cause of several unusual forms of diabetes. For years, doctors and researchers have been stymied by cases of diabetes that differ from known types. Through…
Drink coffee after breakfast, not before, for better metabolic control
University of Bath press release
Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin blocks coronavirus from entering cells, reduces inflammation; observational findings have sparked a placebo-controlled trial
Genetic risk of developing obesity is driven by variants that affect the brain
Over the past decade, scientists have identified hundreds of different genetic variants that increase a person’s risk of developing obesity. But a lot of work remains to understand how these variants translate into obesity. Now scientists at the University of…
Vitamin D deficiency leads to obesity, stunted growth in zebrafish
Using a zebrafish model, researchers from North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation. The results suggest a linkage between vitamin D and metabolic homeostasis,…
Study reveals dietary fructose heightens inflammatory bowel disease
STONY BROOK, NY, September 29, 2020 – Diet remains an important part of disease prevention and management, and a new study suggests that consumption of fructose may worsen intestinal inflammation common to inflammatory bowel diseases (IBD). Led by David Montrose,…
Drug found to correct gene defect that causes immune-driven gut leakiness
UC Riverside-led study is the first to show how tofacitinib rescues gut barrier function from overactive immune cells
National nutrition expert to address need to manage chronic disease during virtual meeting
Dr. James Hill from the University of Alabama to present Keynote Address focused on importance of wellness, especially during the COVID-19 epidemic
Anti-convulsant drug can modify DNA conformation and interact with chromosome proteins
Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin
Effect of time-restricted eating on weight loss
What The Study Did: This randomized clinical trial looked at the effect on weight loss and metabolic health of restricting eating to between 12 p.m. and 8 p.m. among overweight and obese individuals. Authors: Ethan J. Weiss, M.D., of the…
Physicians bring attention to overlooked issue of malnutrition among those with obesity
Poor food quality and inadequate micronutrients raise risk of heart disease and death
Genetic differences in body fat shape men and women’s health risks
New research is revealing how genetic differences in the fat in men’s and women’s bodies affect the diseases each sex is likely to get. University of Virginia researchers Mete Civelek, PhD, Warren Anderson, PhD, and their collaborators have determined that…
A study could provide guideline for exercise training aimed at high blood pressure patient
Brazilian researchers’ finding that exercising in the evening reduces blood pressure more than in the morning can help health professionals choose the time of day for aerobic training depending on the type of anti-hypertensive drug they take
Metformin treatment linked to slowed cognitive decline
Metformin is the first-line treatment for most cases of type 2 diabetes and one of the most commonly prescribed medications worldwide, with millions of individuals using it to optimise their blood glucose levels. A new research study, conducted over six…
Study identifies weight-loss threshold for heart health in patients with obesity, diabetes
Positive effects of metabolic surgery may be independent of weight loss
Fructose made in the brain could be a mechanism driving Alzheimer’s disease
CU Anschutz researcher presents evidence in a new peer-reviewed paper
Diabetes dramatically reduces the kidney’s ability clean itself
AUGUSTA, Ga. (September 22, 2020) – The kidneys often become bulky and dysfunctional in diabetes, and now scientists have found that one path to this damage dramatically reduces the kidney’s ability to clean up after itself. The natural cleanup is…
Nearly 20 percent of americans don’t have enough to eat
COVID-19 escalated numbers for minorities, people with obesity, women
Exercise hormone may modulate genes associated with replication of novel coronavirus
Brazilian researchers observed that in uninfected adipocytes, the hormone irisin altered the expression of genes that regulate ACE-2, which encodes a protein to which the virus binds in order to invade human cells.
Blood vessel growth in muscle is reduced in women after menopause
A new study from the University of Copenhagen demonstrates that formation of small blood vessels is impaired in the muscle tissue of postmenopausal women
Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes
The traditional rice-based diet of some east-Asian population has brought to a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity. An international study led by the University of Bologna and published in the…
Ribeye-eating pigs demonstrate protein quality for humans
URBANA, Ill. – Nearly a decade ago, the UN’s Food and Agriculture Organization (FAO) developed a new index to assess protein quality in foods. The goal, writ large, was to address food security for the world’s most vulnerable populations, creating…
Size and sleep: New research reveals why little things sleep longer
Why does the mouse sleep five times longer than the elephant? Why do babies sleep longer than adults? If these sound like riddles, that’s because they have been. Sleep, in spite of its ubiquity, holds mysteries that have perplexed scientists…
Time-restricted feeding improves health without altering the body’s core clock
When it comes to metabolic health, it’s not just what you eat, it’s when you eat it. Studies have shown that one effective means of losing weight and tackling obesity is to reduce the number of hours in the day…
The hormone glucagon may be a warning light for diabetes
Up to one in four Danes has an unhealthy accumulation of fat in the liver, also known as fatty liver. Fatty liver is rarely the cause of symptoms in itself, but people with fatty liver have an increased risk of…
Could breadfruit be the next superfood? UBC researchers say yes
Breadfruit is sustainable, environmentally friendly and a high-production crop
Fructose and glucose in high fructose corn syrup deliver a one-two punch to health
New study links combination of the two sugars in high fructose corn syrup to heart health risks
New live biotherapeutic products will require regulatory and scientific innovation
Following years of collaboration, research and discussions with leading Microbiome drug developers and health authorities, European regulatory expertise centre lays out key principles when developing live biotherapeutics; quality, efficacy and safety
Scientists explore the obesity paradox, cardiovascular risk of HIV
The newer generation of HIV drugs have turned the once-lethal infection into a chronic condition, and cardiovascular disease has emerged as the leading cause of death in these individuals. Now, Medical College of Georgia scientists are dissecting the also emerging…
Next-gen organoids grow and function like real tissues
Organoids are fast-becoming one of the most cutting-edge tools of modern life sciences. The idea is to use stem cells to build miniature tissues and organs that accurately resemble and behave like their real counterparts. One can immediately appreciate the…
A ferry protein in the pancreas protects it from the stress induced by a high-fat diet
Every time we eat, the glucose level in our body goes up. This spurs our pancreatic machinery into action and through intricate physiological mechanisms, appropriate amounts of insulin are produced, our blood glucose levels are controlled, and we remain healthy.…
Study connects hormones we’re born with to lifetime risk for immunological diseases
Differences in biological sex can dictate lifelong disease patterns, says a new study by Michigan State University researchers that links connections between specific hormones present before and after birth with immune response and lifelong immunological disease development. Published in the…
Studies show strong links between the endocrine system and COVID-19 incidence and mortality
We are just starting to understand the interlinkages between hormones and COVID-19
Painless paper patch test for glucose levels uses microneedles
Tokyo, Japan — Patches seem to be all the rage these days. There are birth control patches, nicotine patches, and transdermal medicinal patches, just to name a few. Now, a team of researchers led by Beomjoon Kim at the Institute…
New insight into how muscles and fat cells work together to make you more fit
Why does exercise training make you more fit? It’s well established that exercising enhances insulin sensitivity and improves our metabolism that, in turn, increases exercise performance. But the biological mechanisms underlying this adaptation are not fully understood. New research published…
Treating hypertension lowers the risk for orthostatic hypotension, or drop in blood pressure upon standing
Embargoed News from Annals of Internal Medicine
Ellipsys system offers greater patient eligibility and reduced time to dialysis
First study to compare percutaneous arteriovenous fistula devices reports positive clinical outcomes
Epigenetic changes precede onset of diabetes
Epigenetic* changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes (T2D). These changes are responsible for the altered methylation activity of specific genes which differs from…
New genetic analysis method could advance personal genomics
Computational method capable of decoding influence of rare variants
Autistic adults have a higher rate of physical health conditions
Autistic individuals are more likely to have chronic physical health conditions, particularly heart, lung, and diabetic conditions, according to a new study by researchers at the University of Cambridge. The results are published today in the journal Autism . Earlier…
Discovery challenges the foundations of gene therapy
A new publication by scientists from Children’s Medical Research Institute has challenged one of the foundations of the gene therapy field and will help to improve strategies for treating serious genetic disorders of the liver. The paper titled, Restoring the…
Changes in blood pressure control over 2 decades among US adults with high blood pressure
What The Study Did: National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care. Authors:…
Common diabetes drug reverses inflammation in the liver
Salk researchers made new inroads into understanding how the commonly prescribed drug metformin works in the body
Different response of mitochondrial respiration in skeletal muscle and adipose tissue to endurance e
In obese individuals, endurance exercise improves fitness and increases the number of mitochondria * and cellular respiration in skeletal muscles. However, the intervention has no effect on cellular respiration in adipose tissue. This is the result of a study by…
Failure to calibrate for ethnicity in fracture epidemiology would do more harm than good
The Fracture Risk Assessment Tool (FRAX®) is a widely used calculation tool that integrates clinical information in a quantitative manner to predict a 10-year probability of major osteoporotic fracture for both women and men in different countries.1 A recent article…