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UrduHudsonAlpha awarded $7 million to expand national health dataset with uncharted genetic variants
Tag: genes
CNIO researchers obtain the first mice born with hyper-long telomeres
The study shows that it is possible to extend life without any genetic modification
Photosynthesis olympics: can the best wheat varieties be even better?
Scientists have put elite wheat varieties through a sort of “Photosynthesis Olympics” to find which varieties have the best performing photosynthesis. This could ultimately help grain growers to get more yield for less inputs in the farm. “In this study…
Leading children’s hospitals to use $8.5 million+ grant to advance collaboration in genomics research
Building a genomics ‘information commons’ will enable more medical centers to share growing volumes of data
Next-generation sequencing used to identify cotton blue disease in the United States
St. Paul, MN (October, 2019)–Cotton blue disease, caused by Cotton leafroll dwarf virus (CLRDV), was first reported in 1949 in the Central African Republic and then not again until 2005, when it was reported from Brazil. In 2017, cotton blue…
Researchers quantify limitations of health reports from direct-to-consumer genetic tests
Findings reported at ASHG 2019 Annual Meeting
Rice blast fungus discovery will drive crop innovation
A secret weapon used by the killer rice blast fungus to infect host plants has been discovered in new research. Rice blast is the most serious disease of rice and is caused by the fungus Magnaporthe oryzae. Each year, blast…
‘The ethics of human genome editing’ special issue published in The CRISPR Journal
New Rochelle, NY, October 15, 2019–The Ethics of Human Genome Editing is the subject of intensive discussion and debate in a special issue of The CRISPR Journal , a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here…
New human reference genome resources help capture global genetic diversity
Findings reported at ASHG 2019 Annual Meeting
Researchers Develop mouse model of human gene involved in Alzheimer’s disease
Findings reported at ASHG 2019 Annual Meeting
Rutgers Shellfish Expert Available to Discuss East Coast Oyster Breeding Project
New Brunswick, N.J. (Oct. 15, 2019) – Rutgers University–New Brunswick shellfish geneticist Ximing Guo is available to comment on a five-year Rutgers-led consortium project to breed better, more disease-resistant East Coast oysters. Improved oyster broodstock will then be made available…
New journal to explore the ‘mysterious ecosystem’ in our gut
A new open access journal from Cambridge University Press, published in partnership with The Nutrition Society, will explore the vital interaction between people and the complex community of microorganisms that live in our digestive systems. The journal, Gut Microbiome ,…
Researchers glean new insights into biological underpinnings of schizophrenia
Findings reported at ASHG 2019 Annual Meeting
DNA fracturing rewires gene control in cancer
Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at…
Protein that triggers plant defenses to light stress identified
To protect against damage from excess light, a newly identified protein triggers a defense mechanism in plant cells
Sox9 reshapes the biliary tree in Alagille syndrome
Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of this condition is abnormalities in the ducts that carry bile, a yellowish liquid that helps…
Family of crop viruses revealed at high resolution for the first time
For the first-time we can take a molecular-level look at one of the world’s deadliest crop killers. The Luteoviridae are pathogenic plant viruses responsible for major crop losses worldwide. Transmitted by aphids, the viruses infect a wide range of food…
Media alert: New articles on the ethics of genome editing published in The CRISPR Journal
All articles are embargoed until 10:00 EST / 15:00 GMT Oct. 10, 2019
Koala epidemic provides lesson in how DNA protects itself from viruses
In animals, infections are fought by the immune system. Studies on an unusual virus infecting wild koalas, by a team of researchers from the University of Massachusetts Medical School and the University of Queensland, reveal a new form of “genome…
Buttons and flies help Hopkins solve longtime DNA mystery
Biologists at Johns Hopkins University have uncovered an important clue in the longtime mystery of how long strands of DNA fold up to squeeze into microscopic cells, with each pair of chromosomes aligned to ensure perfect development. By studying flies,…
Scientists at the MDI biological laboratory are decoding the genetic mechanisms of aging
Discoveries could one day lead to new drugs to prolong healthy human lifespan
Fruit flies help in the development of personalized medicine
People with the same diagnosis typically receive a standard treatment that is not necessarily effective for everyone. With knowledge of the individual patient’s genome, it may be possible in the future to a greater extent to target the medical treatment…
New research uncovers how common genetic mutation drives cancer
Findings in Nature show that targeted therapy for mutated gene can slow or prevent tumor growth in many kinds of cancer
Secrets of lung cancer spread found in patients’ blood and biopsies
Early signs that a patient’s lung cancer may spread and become untreatable can be picked up in samples of their blood and tumour, according to a trio of papers published in Nature Medicine today (Monday). The three studies are all…
Carnegie Mellon and Yale receive NIH grant to further gene editing technique
The peptide nucleic acid-based technique offers an alternative to CRISPR-Cas9
Complete genome of devastating soybean pathogen assembled
An international research collaboration has successfully assembled the complete genome sequence of the pathogen that causes the devastating disease Asian soybean rust. The research development marks a critical step in addressing the threat of the genetically-complex and highly-adaptive fungus Phakopsora…
Confronting colony collapse
Scientists sequence the genomes of the parasitic mites harming the world’s bees
ASHG 2019 in Houston highlights discoveries in genetic research and progress
Improve health, treat disease
Breakthrough in sex-chromosome regulation
Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the…
Stem cell studies offer hope for childhood neurological condition
As both therapy and tool for drug discovery, stem cells present parallel opportunities for treatment
Study presents first genome sequence of Florida panther
The first genome sequence of the Florida panther is presented along with evidence of increased genetic variation in the population
Identifying a gene for canine night blindness
An international team including University of Pennsylvania researchers has identified the mutation associated with a form of canine night blindness that also affects humans
Ancient genomes provide insight into the genetic history of the second plague pandemic
Analysis of 34 ancient plague genomes from the Black Death and succeeding plague epidemics in Europe between the 14th and 17th centuries, reveals how the bacterium diversified after a single introduction
NIH researchers create new viral vector for improved gene therapy in sickle cell disease
‘Forward-oriented’ design might boost treatment effectiveness and broaden use
Father’s obesity in puberty doubles the risk of asthma in his future offspring
A Norwegian study shows that boys who are obese in pre-puberty have an over two times higher risk of having children with asthma than those who are not
A new route to blocking children’s bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading
Machine learning predicts behavior of biological circuits
Neural networks cut modeling times of complex biological circuits to enable new insights into their inner workings
Gene responsible for lutein esterification in bread wheat identified
This work provides insight into the timing and control of esterification, related to storage and nutritional qualities of bread wheat and other grains.
Room for improvement in drug dosage timing in hospitals
Too many hospitals provide medications according to the practicalities of their staffing schedules rather than the ideal dosing times for their patients, according to a new study led by experts at Cincinnati Children’s. The study, published Oct. 1 , 2019,…
Earthquake in the cell
Scientists discover how a modification of the nuclear lamina maintains nuclear shape
Skin-Cells-Turned-to-Heart-Cells Help Unravel Genetic Underpinnings of Cardiac Function
A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.
Fish fathers exhibit signatures of ‘baby brain’ that may facilitate parental care behavior
Many new parents are familiar with terms like “baby brain” or “mommy brain” that hint at an unavoidable decline in cognitive function associated with the hormonal changes of pregnancy, childbirth, and maternal caregiving. A new study of parental care in…
New AI Method May Boost Crohn’s Disease Insight and Improve Treatment
Rutgers-led study uses artificial intelligence to examine genetic signatures of inflammatory bowel illness
Whole genome sequencing could enable personalised cancer treatment, study suggests
Whole genome sequencing of tumour cells could help predict the prognosis of a patient’s cancer and offer clues to identify the most effective treatment, suggests an international study published today in Nature Medicine . Our DNA, the human genome, comprises…
Pineapple genome sequences hint at plant domestication in a single step
As their Latin name indicates, pineapples are truly “excellent fruits”–and thanks to a freshly completed genome sequencing project, researchers have gained a new understanding of how human agriculture has shaped the evolution of this and other crops. An international team…
ESMO 2019: Breast and ovarian cancer drug outperforms targeted hormone therapy in some men
A drug used for breast and ovarian cancer is more effective than modern targeted hormone treatments at slowing progression and improving survival in some men with advanced prostate cancer, phase III clinical trial findings reveal. The PROfound trial compared the…
New CRISPR-Cas9 variant may boost precision in gene editing
Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play…
Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function
Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications. But since most of these variations fall into areas…
Biologists track the invasion of herbicide-resistant weeds into southwestern Ontario
TORONTO, ON (Canada) – A team including evolutionary biologists from the University of Toronto (U of T) have identified the ways in which herbicide-resistant strains of an invasive weed named common waterhemp have emerged in fields of soy and corn…
Genetic markers linked to the start of symptoms of Parkinson’s disease
New therapeutic targets