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UrduSome of the most important tools in the toolbox of modern cell biologists are special chunks of DNA that act like spies, reporting on the cell’s function. The markers, known as reporter genes, allow researchers to get a sense for…
Tag: genes
Predicting cancer versus autism risk in PTEN patients
New Cleveland Clinic led research published in American Journal of Human Genetics
Engineered protein crystals make cells magnetic
If scientists could give living cells magnetic properties, they could perhaps manipulate cellular activities with external magnetic fields. But previous attempts to magnetize cells by producing iron-containing proteins inside them have resulted in only weak magnetic forces. Now, researchers reporting…
Genes ‘lost’ in whales and dolphins helped their ancestors transition to life underwater
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
New insights into the healing capacity of the heart
A group of researchers at Baylor College of Medicine, the Texas Heart Institute and the University of Texas Health Science Center at Houston reveals today in the journal Genes & Development new insights into the recently discovered healing capacity of…
GW Cancer Center Researchers Find Potential Therapeutic Target for Prostate Cancers with PTEN Mutation
PTEN, a tumor suppressor gene mutated in about 20% of prostate cancers, relies on another gene, ARID4B, to function. These findings were published by George Washington University Cancer Center researchers in Nature Communications.
Study finds potential therapeutic target for prostate cancers with PTEN mutation
Researchers from the George Washington University published their findings on the connection between the PTEN gene and the ARID4B gene in Nature Communications
Exploring the risk of ALL in children with Down syndrome
Acute lymphoblastic leukemia (ALL), is the most common childhood cancer. Children with trisomy 21 (Down syndrome) are 10 to 20 times more likely to develop ALL than children without Down syndrome. Historically, children with Down syndrome and ALL had more…
Discovery of sorghum gene that controls bird feeding could help protect crops
A single gene in sorghum controls bird feeding behavior by simultaneously regulating the production of bad-tasting molecules and attractive volatiles, according to a study publishing September 23 in the journal Molecular Plant . This gene, called Tannin1, controls the synthesis…
First glimpse at what ancient Denisovans may have looked like, using DNA methylation data
If you could travel back in time 100,000 years, you’d find yourself living among multiple groups of humans, including anatomically modern humans, Neanderthals, and Denisovans. But exactly what our Denisovan relatives might have looked like had been anyone’s guess for…
New factor in the development of childhood lymphoma
A study recently published in the renowned journal Blood , led by Kaan Boztug, Scientific Director of the St. Anna Children’s Cancer Research Institute, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Adjunct Principal Investigator at the CeMM…
Every step a cell takes, every move they make — scientists will be watching
Scientists have created a novel two-layer microchip to track individual developmental changes in stem cells over longer time periods
Genomic migration analysis shows antibiotic resistance moving from humans to animals
CLEMSON, South Carolina – A Clemson University professor’s research has documented the movement of antibiotic resistance in humans into animal species. College of Science researcher Vincent Richards recently published results that draw attention to reverse zoonosis, or pathogens moving from…
More predictive genetic risk score sought for type 1 diabetes
AUGUSTA, Ga. (Sept. 16, 2019) – Paul Tran is working to develop a highly predictive genetic risk score that will tell parents whether their baby is at significant risk for type 1 diabetes. The ultimate goal, says the MD/PhD student…
Renegade genes caught red handed
Potentially dangerous genes embedded within human DNA were once thought to be locked down by helpful DNA structures called heterochromatin. A University of Arizona researcher disputes that belief and hopes to change the paradigm even further.
Harnessing tomato jumping genes could help speed-breed drought-resistant crops
Researchers from the University of Cambridge’s Sainsbury Laboratory (SLCU) and Department of Plant Sciences have discovered that drought stress triggers the activity of a family of jumping genes (Rider retrotransposons) previously known to contribute to fruit shape and colour in…
Palmer amaranth’s molecular secrets reveal troubling potential
URBANA, Ill. – Corn, soybean, and cotton farmers shudder at the thought of Palmer amaranth invading their fields. The aggressive cousin of waterhemp – itself a formidable adversary – grows extremely rapidly, produces hundreds of thousands of seeds per plant,…
Stem cell researchers reactivate ‘back-up genes’ in the lab
Researchers in Belgium present new findings on X chromosome reactivation
Scientists identify gene as master regulator in schizophrenia
CHOP researchers: Finding may offer a key target for future treatments
Study explores role of mediator protein complex in transcription and gene expression
Did you know that the DNA in any cell of the human body – or any organism for that matter – contains the genetic information required to develop every possible type of cell within that organism? Yet cell types differ…
Buzzkill?
Male honeybees inject queens with blinding toxins during sex
Researchers propose the ‘Alzheimer’s Disease Exposome’ to address environmental risks
USC and Duke researchers say the framework illustrates how environmental and genetic factors interac
First ancient DNA from Indus Valley civilization links its people to modern South Asians
Researchers have successfully sequenced the first genome of an individual from the Harappan civilization, also called the Indus Valley Civilization (IVC). The DNA, which belongs to an individual who lived four to five millennia ago, suggests that modern people in…
The paradox of different house flies with few genetic differences
UH evolutionary biologist publishes findings on sex determinates of house flies
SPEECHLESS, SCREAM and stomata development in plant leaves
The key step in stomata development in plants has been discovered; genes that make stomata and enfor
80% cut in antibiotics entering Thames is needed to avoid surge in superbugs
Modelling study estimates extent of river’s exposure to antibiotic-resistant bacteria
Genome mining reveals novel production pathway for promising malaria treatment
Microbes are well-known among biologists as master engineers of useful small molecules, and there are many tricks of their trade. When researchers at the University of Illinois took a closer look at how a known microbe makes a known so-called…
Discovered a factor that predicts long survival in brain tumor
Researchers of the Josep Carreras Leukaemia Research Institute have discovered an epigenetic lesion
Undercover evolution
Our individuality is encrypted in our DNA, but it is deeper than expected
Scientists use advanced imaging to map uncharted area of genome
Region gives rise to serious disease, discovery could lead to new genetic testing
National study seeks earlier diagnosis of ATTR cardiac amyloidosis in minorities
Boston Medical Center and Columbia University Irving Medical Center awarded grant for new trial
$2M from NIH to extract meaningful data from CRISPR screens
Protein-coding genes comprise a mere 1% of DNA. While the other 99% of DNA was once derided as “junk,” it has become increasingly apparent that some non-coding genes enable essential cellular functions. Wei Li, Ph.D., a principal investigator in the…
These albino lizards are the world’s first gene-edited reptiles
Meet the world’s first gene-edited reptiles: albino lizards roughly the size of your index finger. Researchers used CRISPR-Cas9 to make the lizards, providing a technique for gene editing outside of major animal models. In their study, publishing August 27 in…
Prehistoric puma poo reveals oldest parasite DNA ever recorded
The oldest parasite DNA ever recorded has been found in the ancient, desiccated feces of a puma
Gene linked to autism undergoes changes in men’s sperm after pot use
Further study is needed to determine if the altered gene contributes to autism in children
Gene mutations coordinate to drive malignancy in lung cancer
The identification of a molecular mechanism that causes lung cells to lose their identity, thereby p
Mediating the trade-off — How plants decide between growth or defense
Grow or defend yourself – a decision plants need to make on a daily basis, due to their inability to do both simultaneously. For a long time, it was thought that the reason for the growth-defence trade-off might be a…
Oncologists echo findings that suggest a reduced risk of breast cancer recurrence
Oncologists at VCU Massey Cancer Center were invited to co-author an editorial published in the Journal of Clinical Oncology providing expert commentary on findings from a large study conducted by German investigators that a modified drug combination may lead to…
Grant awarded to MDI Biological Laboratory scientist James A. Coffman, Ph.D.
Will support research on genes governing the health effects of chronic stress
High-fat diet in utero protects against Alzheimer’s later, Temple team shows in mice
(Philadelphia, PA) – A high-fat diet can carry health risks, but for mothers-to-be, it may make all the difference when it comes to Alzheimer’s disease prevention for their children. In a report published online August 26 in the journal Molecular…
Hi-tech bacteria gene tool could prove productive, study finds
Bacteria could be used to produce large quantities of medicines and fuels using a new gene programming technique, research suggests. The powerful method could enable bacteria to be used as cheap and environmentally friendly living factories that make a range…
Scientists have found longevity biomarkers
An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. The results of their study were published in the journal Cell Metabolism . Nowadays, dozens of…
A novel technology for genome-editing a broad range of mutations in live organisms
Salk scientists develop a new gene-editing tool that could help treat many disorders caused by gene
Bacterial sex drives evolution of microbes to conquer and colonize the gut
pioneer study now published in Proceedings of the National Academy of Science – USA, the research te
Moderate to Heavy Drinking During Pregnancy Alters Genes in Newborns, Mothers
Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies’ DNA, according to a Rutgers-led study.
Dartmouth receives $12.5 million grant to establish Center for Quantitative Biology
Dartmouth’s Geisel School of Medicine has been awarded a 5-year, $12.5 million grant from the National Institutes of Health (NIH) to establish a Center for Quantitative Biology (CQB) that will bring together and enhance initiatives in computational biology, bioinformatics, and…
Tweaked CRISPR in neurons gives scientists new power to probe brain diseases
A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR first, one which may fundamentally alter the way scientists study brain diseases. In a paper published August 15 in the journal Neuron…
Genetic redundancy aids competition among bacteria in symbiosis with squid
The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments. Some strains of luminescent bacteria that compete to colonize the…
AAV9 gene therapy vector dramatically increases life span in krabbe disease mouse model
New Rochelle, NY, August 12, 2019–An optimized and newly engineered form of the adeno-associated vector 9 (AAV9) vector used to deliver the galactosylceramidase gene to a mouse model of the inherited neurogenerative and rapidly fatal form of Krabbe dis-ease improved…
Simple protocol for assessing maturation of HPCs from induced pluripotent stem cells
New Rochelle, NY, August 13, 2019-Researchers have developed a guide to help labs standardize the production of mature hepatic-like cells (HPCs) from stem cells and easily compare gene expression of HPCs to actual human liver tissue. This moderately high throughput…