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UrduBACKGROUNDMyocardial ischemia-reperfusion injury (MIRI) poses a prevalent challenge in current reperfusion therapies, with an absence of efficacious interventions to address the underlying causes. AIMTo investigate whether the extracellula
Tag: extracellular vesicles
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators
BACKGROUNDPulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure. Stem cell therapy and mesenchymal stem cells-
Gene therapy relieves back pain, repairs damaged disc in mice
Disc-related back pain may one day meet its therapeutic match: gene therapy delivered by naturally derived nanocarriers that, a new study shows, repairs damaged discs in the spine and lowers pain symptoms in mice.
CHOP Researchers Improve Fitness of Cells Used in Cell Transplants
A readily available, inexpensive small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside of the body, potentially improving the success of procedures like ex vivo gene therapy, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP).
Mitochondrial Changes Linked to High Blood Pressure in Pregnancy
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
A lung injury therapy derived from adult skin cells
Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.
Protein Alters Expression of Extracellular Vesicle Pathway in Colorectal Cancer, Could Serve as Diagnostic Tool
Article title: IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles Authors: Madeline Kuhn, Yang Zhang, John Favate, Mayu Morita, Aurora Blucher, Sukanya Das, Shun Liang, Ranjan Preet, Louis R. Parham, Kathy N. Williams, Sudheer Molugu, Randall J. Armstrong, Wei Zhang, Jiegang…
Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity
Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…
Extracellular vesicles offer new insights into treating endocrine disorders
In a new Scientific Statement released today, the Endocrine Society describes the importance of extracellular vesicles as a new research target for understanding the causes of certain endocrine disorders such as cancer and diabetes and discovering new treatments for these disorders.
Hackensack Meridian CDI Scientists Develop ‘CATCHER’ for Crucial Biomarkers
The EV-CATCHER methodology identifies and captures tiny pieces of genetic material – and shows value in COVID-19 plasma
Improving our understanding of cells
Extracellular vesicles (EVs) were once thought to be waste material discarded by cells. But they have been found to play a critical role in communication between cells, carrying “cargos” of proteins, nucleic acids and other materials. Jessica Tannis of the University of Delaware has been awarded a $1.8 million National Institutes of Health (NIH) Grant to research them.
Bacterial Extracellular Vesicles from Poultry Farm Dust Causes Lung Inflammation in Mice
Article title: Bacterial extracellular vesicles isolated from organic dust induce neutrophilic inflammation in the lung Authors: Velmurugan Meganathan, Regina Moyana, Kartiga Natarajan, Weshely Kujur, Shilpa Kusampudi, Sachin Mulik, Vijay Boggaram From the authors: “In summary, our studies have found that…
A Novel Immunotherapy Proves Effective in Animal Models of Multiple Sclerosis
Jefferson researchers develop an approach to specifically impede the autoimmune response that drives the disease, while leaving the rest of the immune system fully functioning.
Scientists uncover a novel approach to treating Duchenne muscular dystrophy
Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. The study, published in EMBO Reports, reveals a promising new therapeutic approach for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting condition.
Communication between Skeletal Muscle Stem Cells and Fibers Supports Muscle Growth in Mice
A new study suggests that communication between skeletal muscle cells and muscle fibers promotes muscle growth. Adult muscle stem cells, called satellite cells, release extracellular vesicles that are delivered to muscle fibers responsible for contraction, to promote this muscle growth. The first-of-its-kind study is published ahead of print in the journal Function.
Study Explores Role of Extracellular Vesicles in Tissue Repair after Heart Attack
Article title: CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent pro-angiogenic phenotype Authors: Kyle I. Mentkowski, Asma Mursleen, Jonathan D. Snitzer, Lindsey M. Euscher, Jennifer K. Lang From the authors: “Our study was designed to gain mechanistic insight into the…
Engineers develop skin rejuvenation method using stem cells
BINGHAMTON, NY — Vesicles derived from human stem cells can be used to rejuvenate skin, according to a research team including faculty at Binghamton University, State University of New York. The use of stem cell-derived extracellular vesicles (EVs) as a cell-free…
Research on Cellular ‘Packages’ Receives $900k in Federal Funding
Scientists from Johns Hopkins and elsewhere have been selected to receive more than $940,000 to study cellular “packages” that can be used to diagnose disease, track disease status and potentially deliver therapies. The packages, called extracellular vesicles, are ubiquitous among all types of human cells and are being studied for their use in cancer, neurocognitive disorders and other conditions.