Gene variants may increase susceptibility to accumulate Alzheimer’s protein tau, study shows

The toxic protein tau is a key biological feature in the brains of people with Alzheimer’s disease. Yet the factors that make people susceptible or resistant to tau accumulation are not well-understood. A preliminary Mayo Clinic study shows that inherited DNA variants may be associated with developing tau deposits in older adults. The research will be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto April 25–May 1.

Visceral fat delivers signal to the brain that hurts cognition

Excessive weight around our middle gives our brain’s resident immune cells heavy exposure to a signal that turns them against us, setting in motion a crescendo of inflammation that damages cognition, scientists say. It’s known this visceral adiposity, characterized by…

Researchers find gene variants that may increase susceptibility to Alzheimer’s proteins

MINNEAPOLIS – Researchers know that the protein tau develops into tangles in the brains of people with Alzheimer’s disease. But until now they have struggled to understand what factors make you more or less likely to develop these tangles. In…

‘Brain Surfing’: Ultrasound waves focused on prefrontal cortex elevate mood and change brain connectivity in human volunteers

A team of researchers at the University of Arizona has found that low-intensity ultrasound waves directed at a particular region of the brain’s prefrontal cortex in healthy subjects can elevate mood, and decrease connectivity in a brain network that has been shown to be hyperactive in psychiatric disorders. The method uses transcranial focused ultrasound (‘tFUS’), a painless, non-invasive technique to modulate brain function comparable to transcranial magnetic stimulation (‘TMS’), and transcranial direct current stimulation (‘tDCS’). This study shows, for the first time, a correlation between tFUS-induced mood enhancement, and reorganization of brain circuits.

Revving habits up and down, new insight into how the brain forms habits

Each day, humans and animals rely on habits to complete routine tasks such as eating and sleeping. As new habits are formed, this enables us to do things automatically without thinking. As the brain starts to develop a new habit,…

Revving habits up and down, new insight into how the brain forms habits

Each day, humans and animals rely on habits to complete routine tasks such as eating and sleeping. As new habits are formed, this enables us to do things automatically without thinking. As the brain starts to develop a new habit,…

Does smoking increase your risk for dementia and cognitive decline?

Scientists from the Uniformed Services University (USU), Emory University and the University of Vermont have found that cigarette smoking is linked to increased lesions in the brain’s white matter, called white matter hyperintensities. White matter hyperintensities, detected by MRI scan, are associated with cognitive decline and Alzheimer’s disease. These findings may help explain the link between smoking and increased rates of dementia and other forms of cognitive decline.

Scientists Discover New Clue Behind Age-Related Diseases and Food Spoilage

Berkeley Lab scientists have made a surprising discovery that could help explain our risk for developing chronic diseases or cancers as we get older, and how our food decomposes over time.

Temple’s Dr. Silvia Fossati awarded $500,000 grant for Alzheimer’s drug discovery research

(Philadelphia, PA) – Silvia Fossati, PhD, Associate Professor of Pharmacology and Associate Director of the Alzheimer’s Center at Temple at the Lewis Katz School of Medicine, has been awarded a two-year $500,000 grant from The Edward N. and Della L.…

Temple’s Dr. Silvia Fossati awarded $500,000 grant for Alzheimer’s drug discovery research

(Philadelphia, PA) – Silvia Fossati, PhD, Associate Professor of Pharmacology and Associate Director of the Alzheimer’s Center at Temple at the Lewis Katz School of Medicine, has been awarded a two-year $500,000 grant from The Edward N. and Della L.…

One drug, many diseases

It seems too good to be true: a single drug that could treat humanity’s worst afflictions, including atherosclerosis, cancer, Alzheimer’s, Parkinson’s and arthritis. All of these diseases have one thing in common — they involve an inflammatory protein called NLRP3.…

Researchers discover how cells clear misfolded proteins from tissues

Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published February 18 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer’s disease.

Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report

Brussels, 18 February 2020 – Today, at a European Parliament lunch debate hosted by Christophe Hansen MEP (Luxembourg), Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence…