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UrduInvestigators at Mount Sinai Find Strong Association of Kidney Injury with Dasatinib, a Commonly Used Oncological Therapeutic Findings suggest an update may be warranted for current clinical care, screening guidelines, and FDA guidance on adverse events Principal Investigator: Evren U.…
Tag: Kidney Injury
Acute kidney injury not associated with worsening kidney function in persons with CKD
A study of hospitalized persons with chronic kidney disease (CKD) fournd that acute kidney injury (AKI) did not predict worsening of kidney function trajectory once difference in pre-hospitalization characteristically were fully accounted for. Instead, the authors suggest that much of determinants of faster kidney disease decline observed after AKI may already be present before AKI. The findings are published in Annals of Internal Medicine.
Research Unveils Paths to Stopping Cytokine Storms in COVID-19
New research from RUSH University reveals pathways to reducing organ injury caused by severe COVID-19 infection. What began as a study of how the common cold affected patients with certain types of kidney disease evolved to mitigating myocarditis, liver injury and severe kidney injury from COVID-19.
Chemotherapy Drug Increases Kidney Injury in Mouse Model of Lung Cancer
Article title: Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity Authors: Andrew Orwick, Sophia M. Sears, Cierra N. Sharp, Mark A. Doll, Parag P. Shah, Levi J. Beverly, Leah J. Siskind From the authors: “This…
Researchers Identify How HIV/Hepatitis Drug Harms the Kidneys
A first-of-its-kind study identifies mechanisms that explain how a drug commonly used to treat HIV and hepatitis causes kidney disease and kidney injury. The study is published ahead of print in Function.
MD Anderson Research Highlights for December 19, 2022
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include a cell cycle checkpoint inhibitor with potential therapeutic effects in an ovarian cancer subtype, a telementoring program for French-speaking oncology providers in Africa, insights into the relationship between obesity and immunotherapy side effects, updates to the world’s largest cancer drug discovery knowledgebase, improvements to treatment response by blocking the EGFR pathway, and a novel noninvasive diagnostic test for immunotherapy-related kidney injury.
Newly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…
Drug-Induced Kidney Injury Biomarkers, Epithelial Permeability, and More Featured in March 2021 Toxicological Sciences
The March 2021 issue of Toxicological Sciences includes exciting toxicology research in biotransformation, toxicokinetics, and pharmacokinetics; genetic and epigenetic toxicology; neurotoxicology; and more.
Enzyme Activation after Acute Kidney Injury May Lead to Tubule Atrophy
Article title: Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice Authors: Noriyuki Yamashita, Tetsuro Kusaba, Tomohiro Nakata, Aya Tomita, Tomoharu Ida, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Masahiro Uehara, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki From…
Uncovering a ‘suPAR’ culprit behind kidney injury in COVID-19
A new observational study finds patients in the hospital for COVID-19 have high levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.
Computer-based Modeling Identifies how Cell Death Is Regulated in Ischemic Kidney Injury
Article title: T95 nucleophosmin phosphorylation as a novel mediator and marker of regulated cell death in acute kidney injury Authors: Zhiyong Wang, Mostafa Belghasem, Erdjan Salih, Joel Henderson, Chinaemere Igwebuike, Andrea Havasi, Steven C. Borkan From the authors: “In this…
Researchers Reveal Target in Acute Kidney Injury Prevention
Physician-Scientists and other researchers at Rush University Medical Center, in collaboration with colleagues at other institutions, have revealed a new treatment target that may help change the outcome for patients at risk of AKI.
New protein target could lead to breakthrough in kidney injury prevention
Study suggests a protein called suPAR could be targeted to prevent dreaded kidney complications in patients undergoing common medical procedures.
Protein levels in urine after acute kidney injury predict future loss of kidney function
High levels of protein in a patient’s urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.
Study Examines Kidney Injury in Patients Taking Immunotherapy Cancer Medications
In patients taking immune checkpoint inhibitors as a treatment for cancer, 17% experienced acute kidney injury (AKI), 8% experienced sustained AKI, and 3% had potential immune checkpoint inhibitor–related AKI.
• Use of proton pump inhibitors, which are commonly used to treat stomach ulcers or acid reflux, was associated with a higher risk of experiencing sustained AKI.