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UrduBentham Science is pleased to announce the launch of the Open Access journal, New Emirates Medical Journal. The first issue of the journal, by Bentham Science, will be available online by the start of the year, 2020. Dr. Abdullah Shehab…
Tag: PHARMACEUTICAL SCIENCES
Computational ‘match game’ identifies potential antibiotics
CMU software tool speeds discovery using microbial datasets
Do surgeons get lower patient satisfaction ratings when they prescribe fewer opioids?
What The Study Did: A survey study of nearly 1,000 patients who underwent common outpatient surgical procedures reports no significant change in ratings for how satisfied patients were with surgeons when surgeons prescribed fewer opioids. To access the embargoed study:…
New method for quicker and simpler production of lipidated proteins
Some of the body’s proteins are not just made up of amino acids, they are also ‘decorated’ with lipid chains, which significantly influence the biological functions of the protein. An example is the Ras protein, which plays a role in…
MAP Congress 2019: Interpreting molecular alterations for clinical practice
Molecular Analysis for Personalised therapy (MAP) Congress, London, UK, 7-9 November 2019
AI gets access to big novel chemistry space for quick and effective drug discovery
San Diego (CA) – Insilico Medicine, in collaboration with ChemDiv, Inc., launched a drug discovery initiative that aims to use the power of artificial intelligence for screening chemistry space with newly designed compounds. The initiative is expected to identify a…
Clinical research improves health of UK economy and NHS
Findings show clinical research “adds billions to the economy, boosts jobs and generates much needed income for the NHS” according to Chief Executive Jonathan Sheffield New KPMG analysis shows that clinical trials supported by the NIHR Clinical Research Network contribute…
AI could offer warnings about serious side effects of drug-drug interactions
UNIVERSITY PARK, Pa. — The more medications a patient takes, the greater the likelihood that interactions between those drugs could trigger negative side effects, including long-term organ damage and even death. Now, researchers at Penn State have developed a machine…
Drug discovery platform may provide new options for treating mental health illnesses
WEST LAFAYETTE, Ind. – An estimated 46.6 million U.S. adults struggle with mental illnesses, such as anxiety disorder, according to the National Institute of Mental Health. About half of millennials and 75% of Gen-Zers report having quit jobs for mental…
Election 2019: Hope for a national pharmacare plan
The 2019 federal election in Canada brings hope for universal pharmacare if Canadians ensure the elected government delivers on the long-delayed promise of universal access to essential medications, argues an editorial in CMAJ (Canadian Medical Association Journal) . “For Canadians…
Aggressive and agitated behaviors in dementia are better treated without medications
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine . The summaries are not intended to substitute for the full articles as a source of information. 1. Aggressive and…
SLAS Discovery releases special issue
‘Membrane proteins: New approaches to probes, technologies and drug design’ now available
EMIDDT is now the official Journal of Italian Medical Endocrinology Association
Bentham Science Publishers is pleased to announce that the journal Endocrine, Metabolic & Immune Disorders – Drug Targets ( EMIDDT ) is now the official journal of Associazione Medici Endocrinologi (AME) / Italian Medical Endocrinology Association. The journal is currently…
‘Sticky’ gene may help Valium calm nerves
NIH mouse study could prompt scientists to rethink how benzodiazepines work
SLAS Technology releases part 1 of special 2-part issue
Engineering innovations for fundamental biology and translational medicine now available
Study assesses cost of overpayments for topical prescription medications
What The Study Did: This study examined how common and at what cost is the practice of so-called “clawbacks” for topical prescription drugs when an insured patient’s copayment exceeds the insurer’s cost for the drug. To access the embargoed study:…
Brain tissue kept alive for weeks on an artificial membrane
Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have developed a new system for keeping tissue viable for long-term study once transferred from an animal to a culture medium. The new system uses a microfluidic device that…
Safe and efficient tool to reduce seniors’ medication overload
A study shows that MedSafer, an electronic decision-support tool developed by RI-MUHC researchers, helps reduce inappropriate medications prescribed to the elderly
A Canadian essential medicines list must be evidence-based
An essential medicines list in Canada should be evidence-based and independent of conflicting interests, found a study of decision-makers and policy-makers that is published in CMAJ ( Canadian Medical Association Journal ). http://www. cmaj. ca/ press-release-7-oct-19 Prescription drug coverage in…
Molecular nanocarbons with mechanical bonds
Carbon materials with nano-scale periodicity such as graphene and carbon nanotubes, called “nanocarbons,” are expected to become light, highly functional next-generation materials. There have been demands for precise synthesis methods targeting only at the nanocarbon structure with desired property because…
Novel compound interrupts malaria parasite’s lifecycle
Compound inhibits key enzymes, interrupting the parasite’s lifecycle in human organisms and preventing transmission to vector insects. This discovery published in Science involved researchers funded by FAPESP.
Mason scientists invent new technology to streamline drug discovery
Manassas, Va. – George Mason University researchers have discovered the exact location where two proteins responsible for hiding cancer cells from the immune system bind. This discovery provides a novel approach to developing new cancer immunotherapy medicines that can be…
Did providing free essential medicines increase adherence?
Bottom Line: More patients who said they couldn’t afford their medications adhered to treatment when they received free essential medicines for one year in a randomized clinical trial, but not all measures of health outcomes improved. The trial enrolled 786…
New drug overcomes resistance in aggressive breast cancers
A new type of drug that blocks one of cancer’s key evolutionary escape routes from chemotherapy could be used to treat aggressive breast cancers, a new study has shown. Scientists at The Institute of Cancer Research, London, found that the…
Researchers discover a link between two important products of nitric oxide
Oxide plays a key role in cardiovascular and neurodegenerative diseases as well as cancer; experiments reveal a hitherto unknown mechanism underlying the formation of nitroso thiols
Scientists create brain-mimicking environment to grow 3D tissue models of brain tumors
Use of brain-like extracellular matrix allows cell growth and treatment to more closely replicate physiological response
$28m grant funds coordinating center for Rare Diseases Clinical Research Network
The federal agency that oversees a large network of research centers seeking cures for hundreds of rare, disabling and often fatal diseases has named Cincinnati Children’s as its new data management and coordinating center. The five-year, $28 million grant from…
Protein associated with many diseases fully visualized for first time
New drugs could be inspired by understanding how P2X7 protein receptor works
Large-scale mapping of protein networks behind tumor growth in the lungs
Researchers at the University of Copenhagen have used highly sophisticated molecular analyses to identify key proteins in the signaling pathways that cancers use to spread in the body. The study could help in personalizing cancer treatment and develop new drugs.…
Just add water: U-M chemists suggest a fix for insoluble drugs
ANN ARBOR–Stable metal organic frameworks are prized for their ability to capture carbon dioxide or harvest atmospheric water, but U-M researchers have developed a use for unstable metal organic frameworks: as a system for drug delivery. Ninety percent of drugs…
Pioneering red light-activated anti-tumor prodrug reduces side effects
Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient’s blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be…
Entos Pharmaceuticals announces research, development and collaboration agreement
EDMONTON, Alberta, October 2, 2019 — Entos Pharmaceuticals Inc. (“Entos” or the “Company”), a healthcare biotechnology company focused on the development of next-generation nucleic acid-based therapies using their Fusogenix drug delivery platform, today announced it has entered into a research,…
Novel material with strong action against fungi and tumors was developed
Researchers have created a composite with antifungal properties that are 32 times greater than those of silver by irradiating a metallic tungstate with electrons and femtosecond laser.
Codeine misuse in Australia reduced by prescription-only changes
Codeine rescheduling successfully reduces use and harm study finds
A new route to blocking children’s bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading
National Institute on Aging awards $73 million for new Alzheimer’s drug discovery centers
Collaborating institutions will lead development of openly distributed tools to test the efficacy of Alzheimer’s therapies and share results
IU School of Medicine awarded $36 million NIH grant for Alzheimer’s drug discovery center
INDIANAPOLIS — Indiana University School of Medicine has been awarded a grant expected to total $36 million over five years from the National Institutes of Health to launch a drug discovery center to accelerate the development of promising treatments for…
For the first time, UMD professor observes crystallized iron product, hemozoin, made in mammals
Findings could be used to treat sickle cell disease and malaria patients, while opening up diverse research avenues across immunology, parasitology, neuroscience, microbiology, and even urology
CSHL press publishes ‘Conscience and Courage,’ the remarkable life story of Henri Termeer
Cold Spring Harbor, New York, October 1, 2019 — Cold Spring Harbor Laboratory Press (CSHL Press) today announced the publication of Conscience and Courage: How Visionary CEO Henri Termeer Built a Biotech Giant and Pioneered the Rare Disease Industry. Written…
Treatment with long term, low dose antibiotic could help people born with chronic lung condition
Madrid, Spain: Taking a low dose of the antibiotic azithromycin for six months reduces symptoms for patients with the chronic lung condition primary ciliary dyskinesia (PCD), according to research presented at the European Respiratory Society International Congress. [1] PCD is…
Fruit flies live longer with combination drug treatment
A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study led by UCL and the Max Planck Institute for Biology of Ageing. The three drugs are all already in use…
Heart, kidney disease risk factors for adverse effects from gout medication
Heart disease is an independent risk factor for severe adverse skin reactions in patients taking allopurinol, found a study published in CMAJ (Canadian Medical Association Journal) . Allopurinol is a medication most commonly used to treat gout, a painful condition…
Blood test can replace invasive biopsy for more patients with lung cancer
ESMO 2019 Congress, Sept. 27 — Oct. 1, Barcelona, Spain
Mesothelioma trial suggests immunotherapy as an alternative to chemotherapy
ESMO 2019 Congress, Sept. 27 — Oct. 1, Barcelona, Spain
First targeted therapy for cholangiocarcinoma shows clinical benefit in phase III trial
ESMO 2019 Congress, Sept. 27 — Oct. 1, Barcelona, Spain
Targeted therapy slows progression of advanced prostate cancer
ESMO 2019 Congress, Sept. 27 — Oct. 1, Barcelona, Spain
GARDP and Entasis Therapeutics initiate global phase 3 trial of zoliflodacin
The Global Antibiotic Research and Development Partnership (GARDP), a not for profit organisation developing new treatments for drug resistant infections, and Entasis Therapeutics (NASDAQ: ETTX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel antibacterial products, today…
AI system accurately detects key findings in chest X-rays of pneumonia patients within 10 seconds
From 20 minutes or more to 10 seconds. Researchers from Intermountain Healthcare and Stanford University say 10 seconds is about how quickly it took a new system they studied that utilizes artificial intelligence to accurately identify key findings in chest…
First prostate cancer therapy to target genes delays cancer progression
Genetic-based treatment nearly doubles time without disease progression in metastatic prostate cancer
New guidelines: No need to reduce red or processed meat consumption
Embargoed news from Annals of Internal Medicine