English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduWhereas ATM signaling is well known to be activated by DNA doubles-strand breaks, this study provides new evidence that ATM signaling is directly activated by DNA single-strand breaks and activated and regulated by APE1 in eukaryotic systems.
Tag: Dna Damage
Rare Disease’s DNA-Damaging Mutation Could Have Consequences for More Common Conditions
In their pursuit to discover the mechanism behind how RVCL does its damage, researchers found some clues to the DNA damage theory of aging
Regular Exercise Prevents DNA Damage with Aging
Regular aerobic exercise later in life prevents genomic instability characterized by DNA damage and telomere dysfunction
Making Long-Term Memories Requires Nerve-Cell Damage
Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.
Study Details Toxic Elements Found in Stranded Whales, Dolphins Over 15 Years
Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples. Findings reveal how toxicant levels relate to their sex, breed, age and other demographic factors.
Key genes linked to DNA damage and human disease uncovered
Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.
Pesticides to help protect seeds can adversely affect earthworms’ health
Research published in ACS’ Environmental Science & Technology Letters reveals that worms are affected by small amounts of chemicals from pesticide-treated seeds.
Pediatric hepatoblastoma model hints at DNA damage repair pathway for novel therapeutics
Scientists at St. Jude Children’s Research Hospital used genomics to inform the creation of genetic and new cell-line models for hepatoblastoma, which pointed toward the DNA damage repair pathway as a promising therapeutic route.
Mapping DNA damage from exposure to a compound in cigarette, industrial smoke
A compound found in cigarette and industrial smoke, benzo(a)pyrene (BaP), is known to damage DNA. Now, researchers reporting in ACS Central Science have mapped these effects for the first time in human lung cells after BaP exposure, which could help predict exposures that lead to cancers.
Exploring Mutational Signatures Associated with Exposure to Carcinogenic Microplastic Compounds
According to the World Health Organization (WHO), plastic products and their chemical derivatives present in the environment present public health concerns, including elevated risk of cancer. Researchers from Rutgers Cancer Institute of New Jersey explored to what extent common components in microplastic pollutants cause DNA damage in human cells.
Insights into Why Loud Noise is Bad for Your Health
Two new mouse studies provide new insight into how noise exposure can lead to high blood pressure and cancer-related DNA damage.
Brain discovery suggests source of lifelong behavioral issues
Improper removal of faulty brain cells during neurodevelopment may cause lifelong behavioral issues, new research from the University of Virginia School of Medicine suggests. The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s.