With smaller clinical trials, it may be up to doctors to notice rare drug side effects

Tejas Patil, MD, is a medical oncologist. Lisa Ferrigno, MD, MPH, FACS, is a trauma surgeon. Working with lung cancer patients at University of Colorado Cancer Center, they both, independently, noticed something strange: A small percentage of patients taking high…

Aspirin linked to reduction in risk of several cancers of the digestive tract

Aspirin is associated with a reduction in the risk of developing several cancers of the digestive tract, including some that are almost invariably fatal, such as pancreatic and liver cancers. The largest and most comprehensive analysis to date of the…

Researchers Reveal Important Genetic Mechanism Behind Inflammatory Bowel Disease

Researchers at Children’s Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target.

The effects of inflammatory bowel disease on pregnancy

Inflammatory bowel disease (IBD)–including Crohn’s disease and ulcerative colitis–often affects women of childbearing age. A study published in Alimentary Pharmacology & Therapeutics compared the health of pregnant and non-pregnant women with IBD. The study included 2,058 Korean women with IBD…

Differences by race/ethnicity in stage at diagnosis, treatment, survival for cancers

What The Study Did: Data for 950,000 black, white, Asian and Hispanic patients in the U.S. diagnosed with prostate, ovarian, breast, stomach, pancreatic, lung, liver, esophageal, or colorectal cancers were analyzed to examine differences by race and ethnicity in stage…

The Lancet Gasteroenterology & Hepatology: First clinical trial finds probiotic treatment with dead bacteria is better than placebo at alleviating symptoms of irritable bowel syndrome

Probiotic bacteria that have been killed by heat can significantly improve symptoms of irritable bowel syndrome (IBS) compared to placebo, and are not associated with any safety risk, according to a new 12-week, randomised, double-blind, placebo-controlled clinical trial with 443…

Magnetic stimulation may help common problem of fecal incontinence

AUGUSTA, Ga. (April 1, 2020) – A low-cost, noninvasive treatment that uses the power of the magnet to stimulate and heal nerves key to bowel control is under study for the disabling and common problem of stool leakage, or fecal…

Unconscious food cravings may make bariatric surgery less effective for extreme obesity

WASHINGTON–Patients with extreme obesity are prone to unconscious food impulses and cravings that may make it challenging for them to maintain weight loss after bariatric surgery, according to research that was accepted for presentation at ENDO 2020, the Endocrine Society’s…

Unconscious food cravings may make bariatric surgery less effective for extreme obesity

WASHINGTON–Patients with extreme obesity are prone to unconscious food impulses and cravings that may make it challenging for them to maintain weight loss after bariatric surgery, according to research that was accepted for presentation at ENDO 2020, the Endocrine Society’s…

‘Revita’ improves blood glucose levels, liver metabolic health in type 2 diabetes

WASHINGTON–Patients with poorly controlled type 2 diabetes who underwent a novel, minimally invasive, endoscopic procedure called Revita® duodenal mucosal resurfacing (DMR) had significantly improved blood glucose (sugar) levels, liver insulin sensitivity, and other metabolic measures three months later, according to…

Loss of protein disturbs intestinal homeostasis and can drive cancer

Colorectal carcinoma (CRC), the most common form of intestinal cancer, is the second leading cause of cancer related death worldwide. While some patients have a genetic predisposition to the disease, the majority of cases are sporadic and largely influenced by…