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UrduAlcohol researchers have long known that excessive drinking can cause damage to the liver, pancreas, heart, muscle, bone, and brain. However, only a subset of patients with alcohol use disorder (AUD) appear to develop organ damage. New research shows that alcohol-induced gut inflammation is the missing link between unhealthy drinking and organ damage among certain AUD patients.
Tag: Pancreas
Experimental Type 1 Diabetes Drug Shelters Pancreas Cells From Immune System Attack
Scientists at Johns Hopkins Medicine say that an experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, and in some cases, to lengthen the animals’ lifespan.
Pancreatic cancer hijacks a brain-building protein
Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making.
Study links small pancreas size to faster progression to stage 3 Type 1 diabetes
A multicenter, longitudinal study, co-led by investigators at the Vanderbilt Diabetes Research and Training Center (DRTC), has discovered that a small pancreas size predicts a faster progression to stage 3 Type 1 diabetes (T1D), the point at which clinical diagnosis occurs.
Exploring Genetic Changes in Aggressive Pancreatic Cancer
Investigators from Rutgers Cancer Institute of New Jersey and RWJBarnabas Health, the state’s leading cancer program and only National Cancer Institute-designated Comprehensive Cancer Center, investigated genomic alterations based on KRAS status to identify mutations in patients with KRAS wild type (WT). They share their findings, which were presented at the 2023 ASTRO meeting.
Aging alters pancreatic circadian rhythm
The evolutionarily conserved circadian system allows organisms to synchronize internal processes with 24-h cycling environmental timing cues, ensuring optimal adaptation. Like other organs, the pancreas function is under circadian control.
Packaging mRNA for the pancreas
Researchers at Carnegie Mellon University are developing lipid nanoparticles that are designed to carry mRNA specifically to the pancreas. Their study in mice could pave the way for novel therapies for intractable pancreatic diseases, such as diabetes and cancer.
Family’s participation key to advancing diabetes research
A study of one family from Alabama has led Vanderbilt University Medical Center researchers to discover that insulin deficiency, independent of the autoimmunity associated with Type 1 diabetes, is the principal factor leading to a markedly smaller pancreas.
Survival Is a Mixed Matter for Deadliest of Pancreatic Cancers
UC San Diego researchers discover that quality and mix of protein in a type of pancreatic cancer is the determinant of whether the prognosis is poor or very poor.
Single-cell RNA Sequencing IDs Cell Clusters, Genes, Pathways in Pancreas
Article title: Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis Authors: Brandon M. Blobner, Jami L. Saloman, Celeste A. Shelton Ohlsen, Randall Brand, Robert Lafyatis, Rita Bottino, Martin Wijkstrom, Amer H. Zureikat, Kenneth…
Researchers Show Novel Device Improves Blood Sugar Control in Hyperinsulinism Patients Whose Pancreas Has Been Removed
Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin. Using a combination of continuous glucose monitoring, two hormone pumps, and an algorithm, the device, known as the bihormonal bionic pancreas (BHBP) and developed by researchers at Boston University, helped HI patients with diabetes maintain stable glucose levels over the study period.
Diabetes researchers spot dangerous T cells in the pancreas—even in healthy people
It’s long been thought that having “autoreactive” T cells in the pancreas was a sure sign of type 1 diabetes. Yet a new study led by scientists at La Jolla Institute for Immunology (LJI) shows that even healthy people have these cells lurking in the pancreas—in surprisingly high numbers.
Novel diabetes drug candidate shows promising properties in human islets and mouse models
Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.
STUDY FINDS ‘VIRTUAL BIOPSY’ ALLOWS DOCTORS TO ACCURATELY DIAGNOSE PRECANCEROUS PANCREATIC CYSTS
Research from doctors at The Ohio State University Wexner Medical Center finds a new “virtual biopsy” allows them to definitively diagnose cysts in the pancreas with unprecedented accuracy. This means they can eliminate precancerous cysts and potentially save lives.
Researchers Find New Role for Dopamine in Gene Transcription and Cell Proliferation
A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for control of cell proliferation and organ identity and is implicated in cancer, thus having broad implications for health and development of new therapeutics