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UrduEveryone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare…
Tag: genes
An international study reveals how the ‘guardian’ of the genome works
The study is published in ‘Nature Structural & Molecular Biology’
New perspective to understand and treat a rare calcification disease
Researchers developed a new animal model to study a rare genetic disease that can lead to blindness at the age of 40-50.
Thirteen new Alzheimer’s genes identified in first-of-its-kind human genome study
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer’s disease (AD), researchers have identified 13 such variants (or mutations).
Scientists launch ‘herculean’ project creating atlas of human genome variants
SEATTLE (April 1, 2021) – An international consortium of geneticists, biologists, clinicians, mathematicians, and other scientists is determined to take the study of the human genome to the next level – creating a comprehensive atlas of genetic variants to advance…
Bringing gene editing into high schools
Toolkit easily incorporates into any laboratory science course
Everyone poops: Monitoring COVID-19 in wastewater
University of Missouri scientists receive $4 million grant from the National Institutes of Health to examine clues about the rate of infection in communities and virus variants
$1.7 million grant to unlock barley’s genetic superpowers
Project to groom undergrads for agricultural science careers
Prime editing enables precise gene editing without collateral damage
The latest gene editing technology, prime editing, expands the “genetic toolbox” for more precisely creating disease models and correcting genetic problems, scientists say. In only the second published study of prime editing’s use in a mouse model, Medical College of…
UC consortium launches first clinical trial using CRISPR to correct sickle cell gene
Project uses Nobel-Prize-winning technology to directly correct sickle mutation in blood stem cells, addressing underlying cause of debilitating disorder
UMD reports six novel variants for CRISPR-Cas12a in plants, expanding genome engineering
New publication in Nature Communications offers patentable tools to improve the efficiency of food production
Genetic sleuthing reveals endangered river dolphins in Asia as different species
Tissue collection at NOAA Fisheries lab helps reveal genetic distinction
Inflammation-fighting protein could improve treatment of rheumatoid arthritis
SPOKANE, Wash. – New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune…
Study shows survival mechanism for cells under stress
New research reveals how cancer cells endure stress and survive. Publishing in Molecular Cell , an international research team identified mechanisms that human and mouse cells use to survive heat shock and resume their original function – and even pass…
John D. Carpten elected fellow of AACR Academy
American Association for Cancer Research honors distinguished USC Norris Comprehensive Cancer Center scientist
A mouse’s bite holds venomous potential, finds new study
Startling new evidence shows mammal salivary glands and snake venom glands share a common genetic foundation.
Dogs (not) gone wild: DNA tests show most ‘wild dogs’ in Australia are pure dingoes
Almost all wild canines in Australia are genetically more than half dingo, a new study led by UNSW Sydney shows – suggesting that lethal measures to control ‘wild dog’ populations are primarily targeting dingoes.
Correcting altered brain circuit could tackle coinciding obesity and depression
Research has found that obesity and mental disorders such as depression and anxiety seem to often go hand in hand. Researchers at Baylor College of Medicine and collaborating institutions are providing new insights into this association by identifying and characterizing…
Gray’s beaked whales ‘resilient’ to ecosystem changes
An elusive whale species in the Southern Ocean could be resilient to near-future ecosystem changes, according to a new study by the universities of Exeter and Copenhagen. Gray’s beaked whales living in the deep oceans of the Southern Hemisphere are…
Dogs (not) gone wild: DNA tests show most ‘wild dogs’ in Australia are pure dingoes
It’s time to take dingoes out of the doghouse
Researchers discover why cold induces tooth pain and hypersensitivity — and how to stop it
Odontoblasts, the cells that form a tooth’s dentin, have a newly discovered function: Sensing cold, which can trigger pain in teeth; but scientists have also found a way to block the pathway to cold-sensitive teeth
Ancient genomes trace the origin and decline of the Scythians
Because of their interactions and conflicts with the major contemporaneous civilizations of Eurasia, the Scythians enjoy a legendary status in historiography and popular culture. The Scythians had major influences on the cultures of their powerful neighbors, spreading new technologies such…
Gene required for jumping identified in rabbits
Experiments with a rare type of rabbit that can’t jump pinpointed the necessary gene
Circadian clock gene Rev-erb linked to dawn phenomenon in type 2 diabetes
Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn phenomenon, an abnormal increase of blood sugar only in the morning, observed in many patients with type 2 diabetes. They…
Researchers improve plant prime editing efficiency with optimized pegRNA designs
Precision genome editing enables the precise modification of DNA in living cells, thus enabling a breadth of opportunities for plant breeding. Prime editors, developed by Prof. David R. Liu and his colleagues, permit the installation of desired edits in a…
Plant gene found in insect, shields it from leaf toxins
Millions of years ago, aphid-like insects called whiteflies incorporated a portion of DNA from plants into their genome. A Chinese research team, publishing March 25th in the journal Cell , reveals that whiteflies use this stolen gene to degrade common…
Study links genes with function across the human brain
Comparing two neural maps reveals the roles of genes in cognition, perception and feeling
Genome sequenced for pesky pumpkin pathogen
URBANA, Ill. – Pumpkin growers dread the tiny tan scabs that form on their fruit, each lesion a telltale sign of bacterial spot disease. The specks don’t just mar the fruit’s flesh, they provide entry points for rot-inducing fungus and…
Scientists discover how humans develop larger brains than other apes
A new study is the first to identify how human brains grow much larger, with three times as many neurons, compared with chimpanzee and gorilla brains. The study, led by researchers at the Medical Research Council (MRC) Laboratory of Molecular…
Rare genetic variant puts some younger men at risk of severe COVID-19
A subset of young men carry a genetic variant that dampens innate immunity to COVID-19 and may benefit from genetic testing and interferon treatment
Researchers hunt for drugs that keep HIV latent
When the human immunodeficiency virus infects cells, it can either exploit the cells to start making more copies of itself or remain dormant–a phenomenon called latency. Keeping these reservoirs latent is a challenge. A new paper, published in the Proceedings…
How human cells coordinate the start of DNA replication
Cold Spring Harbor Laboratory (CSHL) President and CEO Bruce Stillman has been dissecting DNA replication, a critical step in cell division, since the 1980s. His lab studies how Origin Recognition Complexes–ORCs–coordinate DNA duplication. They discovered how our cells assemble and…
Large-scale genome analysis identifies differences by sex in major psychiatric disorders
Investigators in a multinational study scanned genomes of nearly 200,000 people to find interactions with genes and sex for schizophrenia, major depressive disorder and bipolar disorder.
Massey researcher finds new strategy for fighting brain cancer
Most people relate cholesterol to heart health, but it is also a critical component in the growth and spread of brain cancer. VCU Massey Cancer Center researcher Suyun Huang, Ph.D., recently discovered how cholesterol becomes dysregulated in brain cancer cells…
Upgrade for CRISPR/Cas: Researchers knock out multiple genes in plants at once
Using an improved version of the gene editing tool CRISPR/Cas9, researchers knocked out up to twelve genes in plants in a single blow. Until now, this had only been possible for single or small groups of genes. The approach was…
Cholesterol accumulation contributes to genetic movement disorder
Family finds hope in research breakthrough for rare diagnosis
Budget impact of gene therapy for sickle cell disease
What The Study Did: This economic evaluation estimates the budget impact and affordability of a gene therapy for severe sickle cell disease from the perspective of U.S. Medicaid programs with the highest prevalence of sickle cell disease. Authors: Patrick DeMartino,…
What early-budding trees tell us about genetics, climate change
One of the surest signs of spring is the vibrantly lime-green tinge trees develop as their buds open and tiny new leaves unfurl. Bud-break is the scientific name for this process — a straightforward term for the grand genetic mechanism…
Image analysis based on machine learning reliably identifies haematological malignancies
Myelodysplastic syndrome (MDS) is a disease of the stem cells in the bone marrow, which disturbs the maturing and differentiation of blood cells. Annually, some 200 Finns are diagnosed with MDS, which can develop into acute leukaemia. Globally, the incidence…
Direct reprogramming of oral epithelial cells into mesenchymal-like cells
Point Epithelial cell rests of Malassez derived from the periodontal ligament were transformed into progenitor stem-like cells by stimulation with epigenetic agents. Subsequently, the progenitor stem-like cells were directly differentiated into endothelial, mesenchymal stem, and osteogenic cells that constitute the…
Vape aerosol and gene expression in human lung tissue compared to cigarette sm
Scientific Digital Communications Editor Arran Frood details the latest research findings at Imperial Brands.
Scientists study co-evolutionary relationship between rust fungi and wheat and barberry
Wheat stripe rust is one of the most important wheat diseases and is caused by the plant-pathogenic fungi Puccinia striiformis f. sp. tritici ( Pst ). Though Pst is known to be highly host-specific, it is interestingly able to infect…
Identifying rare genetic variants that increase risk for lung cancer
Lung cancer is the leading cause of cancer death in the U.S. for both men and women. While risk for this disease can be influenced by environmental and lifestyle factors like smoking, studies estimate that 18% of lung cancer cases…
Researchers identify DNA elements that affect MECP2 expression
Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (NRI) have identified and characterized two regions of DNA required for the proper expression of Mecp2/MECP2 in mice and humans. These…
Scientists uncover the underlying genetics that make flies champion fliers
A complex network of wing, muscle and nervous system genes all contribute to flight performance
University of Maryland co-publishes the first full reference genome for rye
Reference genome provides an invaluable resource for crop improvement across wheat, barley, triticale, and rye
Genome scalpel invented for industrial microalgae to efficiently turn CO2 into biofuel
A single-celled alga undergoes genome surgery to remove non-essential parts. This can lead to a most efficient cellular factory for producing sustainable biofuels from sunlight and carbon dioxide. Researchers from the Qingdao Institute of BioEnergy and Bioprocess Technology (QIBEBT) of…
Identifying cells to better understand healthy and diseased behavior
Graphical model an advance in common neuroscience bottleneck
Morris Animal Foundation, the Purina Institute join to study canine cognitive dysfunction
Morris Animal Foundation, a leader in advancing animal health, is partnering with the Purina Institute to advance the knowledge of canine cognitive dysfunction syndrome (CDS), through the Foundation’s Golden Retriever Lifetime Study . By collecting data from the Study’s dog…
Study explores how environmental exposures before conception may impact fetal development
GRAND RAPIDS, Mich. (March 16, 2021) — Older age at the time of conception and alcohol consumption during pregnancy have long been known to impact fetal development. Now, a new report published in Proceedings of the National Academy of Sciences…