Tag: Pharmaceutical Industry

Advancing Synthetic Ephedra-Type Alkaloids With a Two-Step Enzymatic Approach

sarah JonasResearch Results

The development of versatile and efficient biocatalysts for the synthesis of α-hydroxyketones and Ephedra-type alkaloids represents a significant advancement in synthetic biology and medicinal chemistry. In this study, researchers explore the potential of acetolactate synthase (AlsS) from Bacillus subtilis (BsAlsS) for the production of phenylacetylcarbinol (PAC) and its derivatives. Additionally, the study investigates the use of intermediate reductive amination enzymes (introduction of amine group using enzymes) for functionalizing α-hydroxyketones to generate synthetic Ephedra-type alkaloids.

Moffitt Researchers Develop New Chemical Method to Enhance Drug Discovery

sarah JonasResearch Results

Moffitt Cancer Center researchers have developed a novel reagent that enhances the precision of drug synthesis. This innovative method, published in Nature Communications, introduces a new sulfur fluoride exchange (SuFEx) reagent that allows for highly controlled production of crucial sulfur-based molecules, including sulfinamides, sulfonimidamides and sulfoximines.

Digital Science boosts pharma industry support following OntoChem acquisition

sarah JonasAnnouncement

Digital Science is positioning itself to play an even greater role in the pharmaceutical industry’s all-important drug discovery, by helping industry sift through a sea of information and focus on the research that matters.

Harnessing the Power of Proteins in our Cells to Combat Disease

sarah JonasResearch Results

A lab on UNLV’s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery — one that could potentially provide a solution for patients who have run out of options.