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UrduHard-to-study mutations in the human genome, called short tandem repeats, known as STRs or microsatellites, are implicated in the expression of genes associated with complex traits including schizophrenia, inflammatory bowel disease and even height and intelligence. That’s the conclusion of…
Tag: Bioinformatics
Elusive cancer-related protein captured in flight
Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in the cell. The study, published in Nature Structural and Molecular Biology ,…
Elusive cancer-related protein captured in flight
Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in the cell. The study, published in Nature Structural and Molecular Biology ,…
Eelgrass acid and resveratrol produced by cell factories for the first time
Scientists are now able to produce a wide range of sulfated aromatic compounds such as antifouling eelgrass acid, resveratrol and vanillic acid derivatives using microbial production hosts
Eelgrass acid and resveratrol produced by cell factories for the first time
Scientists are now able to produce a wide range of sulfated aromatic compounds such as antifouling eelgrass acid, resveratrol and vanillic acid derivatives using microbial production hosts
Gene-OFF switches tool up synthetic biology
Programmable repressor elements expand the toolbox of synthetic biologists, enabling more sophisticated and accurate diagnostic, environmental, and biofabrication approaches
Elusive cancer-related protein captured in flight
Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in the cell. The study, published in Nature Structural and Molecular Biology ,…
Gene-OFF switches tool up synthetic biology
Programmable repressor elements expand the toolbox of synthetic biologists, enabling more sophisticated and accurate diagnostic, environmental, and biofabrication approaches
Eelgrass acid and resveratrol produced by cell factories for the first time
Scientists are now able to produce a wide range of sulfated aromatic compounds such as antifouling eelgrass acid, resveratrol and vanillic acid derivatives using microbial production hosts
Gene-OFF switches tool up synthetic biology
Programmable repressor elements expand the toolbox of synthetic biologists, enabling more sophisticated and accurate diagnostic, environmental, and biofabrication approaches
New database enhances genomics research collaboration
Sharing datasets that reveal the function of genomic variants in health and disease has become easier, with the launch of a new, open-source database developed by Australian and North American researchers. The MaveDB database is a repository for data from…
Scientists sequence 1,100 plants, illuminating 1 billion years of evolution
GAINESVILLE, Fla. — Plants are evolutionary champions, dominating Earth’s ecosystems for more than a billion years and making the planet habitable for countless other life forms, including us. Now, scientists have completed a nine-year genetic quest to shine a light…
Nature: Scientists present new data on the evolution of plants and the origin of species
There are over 500,000 plant species in the world today. They all evolved from a common ancestor. How this leap in biodiversity happened is still unclear. In the upcoming issue of Nature , an international team of researchers, including scientists…
Flies that ‘stick’ upside down landings use different approach than thought
Flies land upside down on a ceiling using rapid visually mediated rotational maneuvers
Pacifier biosensor could help monitor newborn health
Wearable biosensors that non-invasively monitor health and fitness are growing in popularity among adults. But adapting this technology for use with babies is difficult because the devices are often bulky or have rigid surfaces that could harm infants’ delicate skin.…
Dartmouth Computer scientist receives $1.5 million to build new AI approaches to lung cancer
A $1.5 million National Cancer Institute grant to Computer Scientist Saeed Hassanpour of Dartmouth’s Norris Cotton Cancer Center will be used to build new artificial intelligence (AI) technologies for precision cancer care in lung cancer management
Swarm of tiny drones explores unknown environments
Researchers have presented a swarm of tiny drones that can explore unknown environments completely by themselves. This work, presented in Science Robotics on 23 October, forms a significant step in the field of swarm robotics. The challenge comes from the…
Machine learning’s next frontier: Epigenetic drug discovery
Sanford Burnham Prebys scientists create a machine-learning algorithm that automates high-throughput screens of epigenetic medicines
All is FAIR in biodiversity research: Mandatory data audit at Pensoft’s journals
A thorough data auditing workflow ensures that datasets described in data papers across Pensoft’s OA journal portfolio are fit-to-use prior to peer review
NIH funds new All of Us Research Program genome center to test advanced sequencing tools
HudsonAlpha awarded $7 million to expand national health dataset with uncharted genetic variants
BARseq builds a better brain map
Cold Spring Harbor Laboratory Professor Anthony Zador has taken the next step in his quest to solve exactly how the brain is wired. Zador, a neuroscientist whose lab studies how the brain’s circuitry mediates and controls complex behaviors, set out…
First scientific description of elusive bird illuminates plight of Borneo’s forests
Scientists document new species with eye toward the fate of a shrinking forest biodiversity hotspot and its inhabitants
Tiny droplets allow bacteria to survive daytime dryness on leaves
Bacteria on the surface of leaves survive dryness during the day by huddling in tiny droplets — a finding that may help scientists support microbiome health in crops and natural plants
The lunar cycle drives the nightjar’s migration
GPS tracking data reveals that the foraging activity of the European nightjar more than doubles during moon-lit nights, and the birds then migrate simultaneously about 10 days after the full moon, according to a study published October 15 in the…
Lehigh to present research, new programs at BMES 2019
3DP for tissue regeneration, biomechanics of Ebola adhesion, and more take center stage in Philadelphia
10 million Euro ERC Synergy Grant awarded for study of medieval populations
IAS’s Patrick Geary among four PIs to head study
Scientists at the MDI biological laboratory are decoding the genetic mechanisms of aging
Discoveries could one day lead to new drugs to prolong healthy human lifespan
Key uncertainties identified for models of mosquito distribution in the US
Understanding model limitations could improve strategies to deal with mosquito-borne diseases
Virtual review of cancer clinical trial treatment options quicker than conventional method
WASHINGTON — Using virtual, cloud-based, interconnected computing techniques applied to 51,000 variables, researchers at Georgetown University Medical Center and colleagues reduced the time needed to assess a cancer patient’s tumor profile and suitability for clinical trials from 14 to 4…
CTFH and Insilico collaborate on accelerating first-in-class therapeutics using AI
Research Collaboration Highlights The collaboration aims to accelerate drug discovery and development with an AI-enabled platform for triple-negative breast cancer; CTFH is one of the top pharmaceutical companies in China focused on innovative drug discovery and development, with a strong…
Threshold-dependent gene drives in wild populations
The BioScience Talks podcast features discussions of topical issues related to the biological sciences. By altering the heritability of certain traits, gene drive technologies have the potential to spread desired genes through wild populations. In practice, this could lead to…
CNIO and University of Wurzburg solve 3D structure of ‘nanomachine’ that makes tuberculosis virulent
The long-awaited finding is published in Nature
Tau-mediated RNA splicing errors linked to Alzheimer’s disease
A collaborative study published today in the journal Cell Reports provides evidence for a new molecular cause for neurodegeneration in Alzheimer’s disease. The study, led by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research…
New bioinformatics hub at UChicago enables next-gen infectious disease research
NIH-funded resource merges pathogen databases and adds AI capabilities
Complete genome of devastating soybean pathogen assembled
An international research collaboration has successfully assembled the complete genome sequence of the pathogen that causes the devastating disease Asian soybean rust. The research development marks a critical step in addressing the threat of the genetically-complex and highly-adaptive fungus Phakopsora…
ASHG 2019 in Houston highlights discoveries in genetic research and progress
Improve health, treat disease
New method to purify cell types to high purity
Cell type purification by single-cell transcriptome-trained sorting
Breakthrough in sex-chromosome regulation
Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the…
Study presents first genome sequence of Florida panther
The first genome sequence of the Florida panther is presented along with evidence of increased genetic variation in the population
Swimming toward an ‘internet of health’?
In recent years, the seemingly inevitable “internet of things” has attracted considerable attention: the idea that in the future, everything in the physical world — machines, objects, people — will be connected to the internet. Drawing on lessons learned from…
Amputees merge with their bionic leg
Djurica Resanovic lost his leg in a motorbike accident several years ago which resulted in amputation above the knee. Thanks to novel neuroprosthetic leg technology, Resanovic was successfully merged with his bionic leg during clinical trials in Belgrade, Serbia. “After…
Three UC San Diego Researchers Receive Top Honors with NIH Director’s Awards
Three University of California San Diego researchers have received prestigious awards through the National Institutes of Health (NIH) High-Risk, High-Reward Research Program, including the Pioneer Award, the program’s top honor.
Inscripta launches the world’s first benchtop platform for digital genome engineering
The Onyx™ platform enables scientists to create libraries of millions of precisely engineered single cells in one experiment through a fully automated workflow
New species of parasite is identified in fatal case of visceral leishmaniasis
Phylogenomic analysis shows that pathogen isolated in Brazilian hospital does not belong to the genus Leishmania; researchers are investigating whether this species alone can cause severe disease or intensifies symptoms in co-infected patients
Three UC San Diego researchers receive top honors with NIH Director’s Awards
Rob Knight, PhD, awarded the Pioneer Award; Omar Akbari, PhD, and Shadi Dayeh, PhD, receive the New Innovator Award, recognizing innovative approaches to biomedical research
The future of bone healing
UTA researchers pursuing innovative treatment for cranial injuries
Underwater manatee chatter may aid in their conservation
Listening in on manatee conversations could help restore populations of this endangered marine mammal. Each manatee has its own voice: their calls can be traced back to specific individuals, offering a way to estimate how many of them are present…
Cellular senescence is associated with age-related blood clots
Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September 24 edition of Cell Reports…
New mechanisms that regulate pluripotency in embryonic stem cells are discovered
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation
DNA is held together by hydrophobic forces
Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the two sides of the DNA structure. Instead, water is the key.…