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UrduDiet rich in sugar, fat damages immune cells in digestive tracts of mice
Tag: IMMUNOLOGY/ALLERGIES/ASTHMA
How to predict severe influenza in hospitalised patients
Published today in Nature Communications, the team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), Alfred Health and Monash University sought to understand which patients would recover quickly from influenza and which would become severely ill.
Agents that target viral RNA could be the basis for next generation anti-viral drugs
A new approach to tackling viruses by targeting the ‘control centre’ in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.
Do bacteria in the mouth affect risk of developing rheumatoid arthritis?
Investigators found similarities in the bacterial composition of the mouth among patients with early rheumatoid arthritis and those at risk of developing the disease, compared with healthy individuals who were not at risk. The findings come from a study published…
Study uncovers potentially avoidable acute care use for vaccine-preventable illnesses in lupus patients
A new study published in Arthritis Care & Research indicates that few individuals with the autoimmune disease lupus who were publicly insured through Medicaid received recommended vaccines in 2000-2010. Also, those who were unvaccinated needed more acute care for vaccine-preventable…
Can cancer cells help cure paralysis and reverse brain damage?
UMass Amherst biomedical engineer awarded NIH Trailblazer grant to advance promising research
Testing tool can quickly distinguish between viral and bacterial infections
The approach could help clinicians know when to correctly prescribe antibiotics
Researchers identify protein “signature” of severe COVID-19
These findings could help researchers identify the mechanisms that cause severe disease.
Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies
The most complete picture yet is coming into focus of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. In the journal Science, researchers at The University…
Chronic attack on the aging nervous system
Aging is the biggest risk factor for perturbation of the nervous system, even in the absence of distinct disease or trauma. For yet unknown reasons, the impulse conducting, myelinated projections and synaptic connections between nerve cells are especially vulnerable to…
Your stomach may be the secret to fighting obesity
Scientists believe a stomach-specific protein plays a major role in the progression of obesity, according to new research in Scientific Reports . The study co-authored by an Indiana University School of Medicine researcher, could help with development of therapeutics that…
Population-based study shows air pollution exposure contributes to childhood asthma
Children born in Sarnia, Ontario at higher risk of developing asthma, compared to neighbouring cities
A trait of the rare few whose bodies naturally control HIV: “trained” immune cells
Scientists at the Ragon Institute of MGH, MIT and Harvard discover that “elite controllers” have myeloid dendritic cells that display characteristics of trained innate immune cells.
Glandular fever increases the risk of depression
New research shows that patients who have had contact with the hospital due to serious glandular disease have a greater risk of subsequently developing depression. The study from iPSYCH is the largest yet to show a correlation between glandular fever and
Research with neutrons for better mRNA medicines
If not before, then certainly since the first messenger RNA (mRNA) vaccines to combat the SARS CoV2 virus were approved in Germany, mRNA has become a recognized term even outside scientific circles. What is less well known is that mRNA…
CityU scientists invent cryomicroneedles for intradermal therapeutic cell delivery
A research team led by City University of Hong Kong (CityU) scientists recently developed a new generation of microneedles technology which allows the intradermal delivery of living cells in a minimally invasive manner. Their experiment showed that vaccination using therapeutic…
Intranasal influenza vaccine enhances immune response and offers broad protection, researchers find
ATLANTA–An influenza vaccine that is made of nanoparticles and administered through the nose enhances the body’s immune response to influenza virus infection and offers broad protection against different viral strains, according to researchers in the Institute for Biomedical Sciences at…
Large collaboration creates cell atlas of COVID-19 pathology
Single-cell analysis of autopsy samples from COVID-19 patients shows how the lungs repeatedly tried, and failed, to repair themselves
Inflammation and inflammatory markers of head and neck tumor
‘Head and Neck Cancer: Hallmarks of The Inflammation Ecosystem’ aims to highlight the significant roles of inflammation in head and neck malignancy. This entails the screening, diagnosis, treatment as well as follow-up schemes of head and neck cancer patients. Now,…
Urine of COVID-19 patients could predict who will develop severe disease
Inflammatory markers were higher in people with high blood pressure and diabetes
Physical activity reduces cardiovascular risk in rheumatic patients
People with diseases such as rheumatoid arthritis and lupus are more likely to have heart attacks, angina, and strokes. A review of the scientific literature on the subject shows that regular exercise improves vascular function in these patients
High dose of vitamin D fails to improve condition of moderate to severe COVID-19 patients
A clinical trial was conducted with 240 patients who were given 200,000 IU of vitamin D3 on admission to hospital. The supplementation did not reduce length of stay or affect the proportion requiring intensive
Scientists unmask new neutralizing antibody target on SARS-CoV-2 spike protein
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity
New insights on inflammation in COVID-19
Severe cases of COVID-19 can involve extensive inflammation in the body, and clinicians have wondered if this state is similar to what are called cytokine storm syndromes, in which the immune system produces too many inflammatory signals that can sometimes lead to organ failure and death.
Gut’s immune response in COVID-19 may not provide efficient protection of other organs
A study of immune cells circulating in the blood hints the gut’s immune response to COVID-19 infection may not provide sufficient whole-body immunity from the virus
Overgrowth of gut yeast in newborns may increase asthma risk
Trans-kingdom imbalances in the gut microbes of newborns may increase the risk of asthma later in life, providing a possible target for treating the condition
Patients who are obese or overweight are at risk for a more severe course of COVID-19
COVID-19 patients who are overweight or obese are more likely to develop a more severe infection than patients of healthy weight, and they require oxygen and invasive mechanical ventilation more often.
POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner
Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner.…
Sweat sensor could alert doctors, patients to looming COVID cytokine storm (video)
WASHINGTON, April 16, 2021 — Early in the COVID-19 pandemic, doctors recognized that patients who developed a “cytokine storm” — a surge of pro-inflammatory immune proteins — were often the sickest and at highest risk of dying. But a cytokine…
One dose of SARS-CoV-2 mRNA vaccine may induce immunity in recovered patients, suggests new analysis
A new analysis of antibody and B cell responses in 44 people who received either the Pfizer or Moderna mRNA SARS-CoV-2 mRNA vaccines shows that only one dose may be needed for previously infected patients who have since recovered. The…
CNIO researchers discover that a drug already in use in humans corrects obesity in mice
The approach, with ,no side effects, was to treat obesity as an inflammatory disease
Self-assembling nanofibers prevent damage from inflammation
Nanomaterials strategically activate the immune system to fight inflammation as effectively as current standard therapeutics
Level of chromosomal abnormality in lung cancer may predict immunotherapy response
Dana-Farber researchers find patients whose tumors have low aneuploidy levels often have better outcomes following treatment with immune checkpoint inhibitors
First images of cells exposed to COVID-19 vaccine reveal native-like Coronavirus spikes
New research has for the first time compared images of the protein spikes that develop on the surface of cells exposed to the Oxford-AstraZeneca vaccine to the protein spike of the SARS-CoV-19 coronavirus.
New formulation of existing medicines prove highly effective against drug-resistant fungus
CLEVELAND–A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the presence of the fungus Candida auris ( C. auris ) on skin, controlling its spread and potentially keeping it…
Understanding itch: New insights at the intersection of the nervous system & immune system
Eczema, or atopic dermatitis (AD), is sometimes called “the itch that rashes.” Often, the itch begins before the rash appears, and, in many cases, the itchiness of the skin condition never really goes away.
Stem cell transplants prevent relapses of most common childhood cancer
Children and young adults who receive CAR T-cell therapy for the most common childhood cancer – acute lymphoblastic leukemia – suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem…
Pollen season in Switzerland earlier and more intense due to climate change
Pollen from trees, grasses and weeds are causing seasonal allergies for approximately one fifth of the Swiss population every year. A study now found that due to climate change, the pollen season has shifted substantially over the past 30 years…
Study reveals large and unequal health burden from air pollution in California’s Bay Area
Results underscore need for urgent action to reduce air pollution, particularly in overburdened areas
IIVS to collaborate with RIFM to develop non-animal technologies for respiratory allergy
The Institute for In Vitro Sciences (IIVS) and the Research Institute for Fragrance Materials (RIFM) announce a collaboration to develop a non-animal ( in vitro ) test designed to assess potential respiratory allergens. Environmental, consumer, or workplace exposure to respiratory…
Why SARS-CoV-2 replicates better in the upper respiratory tract
“SARS-CoV-2 and SARS-CoV are highly similar genetically, generate a homologous repertoire of viral proteins, and use the same receptor to infect human cells. However, despite these similarities, there are also important differences between the two viruses”, says Ronald Dijkman from…
Pathways leading to the extramedullary development of tissue-resident lymphocytes found
Researchers from the University of Science and Technology of China (USTC) of the Chinese Academy of Science (CAS), teamed up with scientists from Aix Marseille University, discovered that hematopoietic progenitors possessed the differentiation potential to type 1 innate lymphoid cells…
COVID-19 antibody tests, even rapid finger pricks, are effective, new study finds
The “litmus test” screening methods provide reliable and inexpensive alternatives in patient care settings.
Researchers reveal SARS-CoV-2 distribution and relation to tissue damage in patients
Researchers have mapped the distribution of SARS-CoV-2, the virus that causes COVID-19, in deceased patients with the disease, and shed new light on how viral load relates to tissue damage.
Researchers reveal SARS-CoV-2 distribution and relation to tissue damage in patients
The first known study to measure SARS-CoV-2 viral load in a variety of organs and tissues may aid our understanding of how COVID-19 develops following infection
High-fiber diet may play a role in controlling the inflammation associated with COVID-19
In vitro treatment of cells with these molecules reduced the expression of a gene that plays a key role in viral cell entry and a cytokine receptor.
Anti-inflammatory drug protects against lethal inflammation from COVID-19 in animal models
Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19. In a study published today in the journal Cell ,…
Contact lenses poised to detect cancer, treat disease and replace digital screens
Newly-published “contact lens technologies of the future” paper reviews innovative uses for disease detection and therapy, drug delivery, vision enhancement and mor
Analysis of the sensitivity of the UK (B.1.1.7) and South African (B.1.351) variants to SARS-CoV-2
The B.1.1.7 and B.1.351 variants of SARS-CoV-2 were first detected in the UK and South Africa respectively, and have since spread to many other countries. Scientists from the Institut Pasteur joined forces with Orléans Regional Hospital, Tours University Hospital, Créteil…
Inflammation-fighting protein could improve treatment of rheumatoid arthritis
SPOKANE, Wash. – New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune…