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UrduLOS ANGELES, CA, October 23, 2019 – Parents of children affected by Phelan-McDermid syndrome (PMS) announce the formation of CureSHANK, a nonprofit organization to accelerate drug development in PMS and other diseases related to the SHANK genes. As one of…
Tag: genes
A weapon to make a superbug to become more deadly
A recent research led by a scientist at City University of Hong Kong (CityU) has discovered an easily transmitted DNA piece that can make a new type of hyper-resistant and deadly superbug become hyper-virulent quickly, posing an unprecedented threat to…
Glucose wears down circadian clocks in obesity, may drive cardiovascular risk
AUGUSTA, Ga. (Oct. 22, 2019) – High glucose in obesity appears to gum up the works of the circadian clocks inside our cells that help regulate the timing of many body functions across the 24-hour day and drive the risk…
LSU Health New Orleans awarded $1.74 million for Usher Syndrome antisense therapy research
New Orleans, LA – Jennifer J. Lentz, PhD, Associate Professor at LSU Health New Orleans Neuroscience Center of Excellence and Departments of Otorhinolaryngology, Genetics and Ophthalmology, in collaboration with Robert K. Koenekoop MD, PhD and Professor of Pediatric Surgery, Human…
Machine learning’s next frontier: Epigenetic drug discovery
Sanford Burnham Prebys scientists create a machine-learning algorithm that automates high-throughput screens of epigenetic medicines
By cutting out one gene, researchers remove a tadpole’s ability to regenerate
Tadpoles of frogs that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the…
New therapeutic strategy may help reverse autism behavioral abnormalities
Houston — (Oct., 21, 2019) — Autism is a developmental disorder that affects 1 in 59 children in the U.S. Mutations in specific genes, such as PTEN, can explain many autism cases. While children with mutations in PTEN exhibit autism,…
Defining the centromere
Investigating the roles of kinetochores in cell division
Salk scientists receive $12.9 million from NIH BRAIN Initiative
LA JOLLA–(October 21, 2019) Salk Institute scientists Nicola Allen, Eiman Azim, Margarita Behrens, and Joseph Ecker have been named recipients in the 2019 round of grants from the National Institutes of Health (NIH) to better understand the brain. The grants,…
New diagnostic method finds aggressive tumors
Researchers at Karolinska Institutet in Sweden have developed a new cheap method that can identify highly heterogeneous tumours that tend to be very aggressive, and therefore need to be treated more aggressively. The technique is presented in the scientific journal…
NIH funds new All of Us Research Program genome center to test advanced sequencing tools
HudsonAlpha awarded $7 million to expand national health dataset with uncharted genetic variants
CNIO researchers obtain the first mice born with hyper-long telomeres
The study shows that it is possible to extend life without any genetic modification
Photosynthesis olympics: can the best wheat varieties be even better?
Scientists have put elite wheat varieties through a sort of “Photosynthesis Olympics” to find which varieties have the best performing photosynthesis. This could ultimately help grain growers to get more yield for less inputs in the farm. “In this study…
Leading children’s hospitals to use $8.5 million+ grant to advance collaboration in genomics research
Building a genomics ‘information commons’ will enable more medical centers to share growing volumes of data
Next-generation sequencing used to identify cotton blue disease in the United States
St. Paul, MN (October, 2019)–Cotton blue disease, caused by Cotton leafroll dwarf virus (CLRDV), was first reported in 1949 in the Central African Republic and then not again until 2005, when it was reported from Brazil. In 2017, cotton blue…
Researchers quantify limitations of health reports from direct-to-consumer genetic tests
Findings reported at ASHG 2019 Annual Meeting
New human reference genome resources help capture global genetic diversity
Findings reported at ASHG 2019 Annual Meeting
Researchers Develop mouse model of human gene involved in Alzheimer’s disease
Findings reported at ASHG 2019 Annual Meeting
Rice blast fungus discovery will drive crop innovation
A secret weapon used by the killer rice blast fungus to infect host plants has been discovered in new research. Rice blast is the most serious disease of rice and is caused by the fungus Magnaporthe oryzae. Each year, blast…
‘The ethics of human genome editing’ special issue published in The CRISPR Journal
New Rochelle, NY, October 15, 2019–The Ethics of Human Genome Editing is the subject of intensive discussion and debate in a special issue of The CRISPR Journal , a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here…
Rutgers Shellfish Expert Available to Discuss East Coast Oyster Breeding Project
New Brunswick, N.J. (Oct. 15, 2019) – Rutgers University–New Brunswick shellfish geneticist Ximing Guo is available to comment on a five-year Rutgers-led consortium project to breed better, more disease-resistant East Coast oysters. Improved oyster broodstock will then be made available…
DNA fracturing rewires gene control in cancer
Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at…
Protein that triggers plant defenses to light stress identified
To protect against damage from excess light, a newly identified protein triggers a defense mechanism in plant cells
New journal to explore the ‘mysterious ecosystem’ in our gut
A new open access journal from Cambridge University Press, published in partnership with The Nutrition Society, will explore the vital interaction between people and the complex community of microorganisms that live in our digestive systems. The journal, Gut Microbiome ,…
Researchers glean new insights into biological underpinnings of schizophrenia
Findings reported at ASHG 2019 Annual Meeting
Sox9 reshapes the biliary tree in Alagille syndrome
Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of this condition is abnormalities in the ducts that carry bile, a yellowish liquid that helps…
Family of crop viruses revealed at high resolution for the first time
For the first-time we can take a molecular-level look at one of the world’s deadliest crop killers. The Luteoviridae are pathogenic plant viruses responsible for major crop losses worldwide. Transmitted by aphids, the viruses infect a wide range of food…
Media alert: New articles on the ethics of genome editing published in The CRISPR Journal
All articles are embargoed until 10:00 EST / 15:00 GMT Oct. 10, 2019
Koala epidemic provides lesson in how DNA protects itself from viruses
In animals, infections are fought by the immune system. Studies on an unusual virus infecting wild koalas, by a team of researchers from the University of Massachusetts Medical School and the University of Queensland, reveal a new form of “genome…
Buttons and flies help Hopkins solve longtime DNA mystery
Biologists at Johns Hopkins University have uncovered an important clue in the longtime mystery of how long strands of DNA fold up to squeeze into microscopic cells, with each pair of chromosomes aligned to ensure perfect development. By studying flies,…
Scientists at the MDI biological laboratory are decoding the genetic mechanisms of aging
Discoveries could one day lead to new drugs to prolong healthy human lifespan
Fruit flies help in the development of personalized medicine
People with the same diagnosis typically receive a standard treatment that is not necessarily effective for everyone. With knowledge of the individual patient’s genome, it may be possible in the future to a greater extent to target the medical treatment…
New research uncovers how common genetic mutation drives cancer
Findings in Nature show that targeted therapy for mutated gene can slow or prevent tumor growth in many kinds of cancer
Carnegie Mellon and Yale receive NIH grant to further gene editing technique
The peptide nucleic acid-based technique offers an alternative to CRISPR-Cas9
Secrets of lung cancer spread found in patients’ blood and biopsies
Early signs that a patient’s lung cancer may spread and become untreatable can be picked up in samples of their blood and tumour, according to a trio of papers published in Nature Medicine today (Monday). The three studies are all…
Stem cell studies offer hope for childhood neurological condition
As both therapy and tool for drug discovery, stem cells present parallel opportunities for treatment
Study presents first genome sequence of Florida panther
The first genome sequence of the Florida panther is presented along with evidence of increased genetic variation in the population
Identifying a gene for canine night blindness
An international team including University of Pennsylvania researchers has identified the mutation associated with a form of canine night blindness that also affects humans
Complete genome of devastating soybean pathogen assembled
An international research collaboration has successfully assembled the complete genome sequence of the pathogen that causes the devastating disease Asian soybean rust. The research development marks a critical step in addressing the threat of the genetically-complex and highly-adaptive fungus Phakopsora…
Confronting colony collapse
Scientists sequence the genomes of the parasitic mites harming the world’s bees
ASHG 2019 in Houston highlights discoveries in genetic research and progress
Improve health, treat disease
Breakthrough in sex-chromosome regulation
Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the…
Ancient genomes provide insight into the genetic history of the second plague pandemic
Analysis of 34 ancient plague genomes from the Black Death and succeeding plague epidemics in Europe between the 14th and 17th centuries, reveals how the bacterium diversified after a single introduction
NIH researchers create new viral vector for improved gene therapy in sickle cell disease
‘Forward-oriented’ design might boost treatment effectiveness and broaden use
Father’s obesity in puberty doubles the risk of asthma in his future offspring
A Norwegian study shows that boys who are obese in pre-puberty have an over two times higher risk of having children with asthma than those who are not
A new route to blocking children’s bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading
Machine learning predicts behavior of biological circuits
Neural networks cut modeling times of complex biological circuits to enable new insights into their inner workings
Gene responsible for lutein esterification in bread wheat identified
This work provides insight into the timing and control of esterification, related to storage and nutritional qualities of bread wheat and other grains.
Room for improvement in drug dosage timing in hospitals
Too many hospitals provide medications according to the practicalities of their staffing schedules rather than the ideal dosing times for their patients, according to a new study led by experts at Cincinnati Children’s. The study, published Oct. 1 , 2019,…
Earthquake in the cell
Scientists discover how a modification of the nuclear lamina maintains nuclear shape