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UrduFor the first time, scientists are able to directly compare the different kinds of injury that mechanical ventilation causes to cells in the lungs.
Tag: Lung Injury
Serious flu damage prevented by compound that blocks unnecessary cell death
In a study in mice published in Nature, a research team showed that a newly developed compound was able to block necroptosis, a type of cell death that leads to lung inflammation and damage following infection with the flu virus.
Promising Gene-Based Approaches to Repair Lethal Lung Injury in the Elderly from COVID-19, Pneumonia, Flu, Sepsis
Discovery from the lab of Youyang Zhao, PhD, from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago offers promising treatment approaches for acute respiratory distress syndrome (ARDS) in the elderly that can be caused by severe COVID-19, pneumonia, flu or sepsis.
A lung injury therapy derived from adult skin cells
Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.
UNC Researchers Tackle the E-cigarette or Vaping Product Use–associated Lung Injury (EVALI) Epidemic
Although doctors and researchers sympathize with smokers wanting to quit smoking, scientists are discovering that vaping might not be a healthier alternative to smoking, especially in adolescents. E-cigarette products have recently been linked to a new, serious lung condition known as E-cigarette or Vaping Product Use-associated Lung Injury, or EVALI, which primarily affects youth and young adults. In 2019, the illness was declared an epidemic by the CDC.
Light Exposure Enhances Circadian Rhythm Protein, Protects against Bacterial Lung Injury in Mice
Article title: Intense light elicited alveolar type 2 specific circadian PER2 protects from bacterial lung injury via BPIFB1 Authors: Yoshimasa Oyama, Sydney R. Shuff, Nana Burns, Christine U. Vohwinkel, Tobias Eckle From the authors: “Our studies indicate that light-elicited [alveolar…
Blocking Protein in Mouse Lung Cells May Prevent or Heal Lung Injury
Article title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b Authors: Ian Rochford, Jagdish Chandra Joshi, Sheikh Rayees, Mumtaz Anwar, Md Zahid Akhter, Lakshmi Yalagala, Somenath Banerjee, Dolly Mehta From the authors: “Owing to…
Decades After Toxic Exposure, 9/11 First Responders May Still Lower Their Risk of Lung Injury
Losing weight and treating excess levels of fat in the blood may help prevent lung disease in firefighters exposed to dangerous levels of fine particles from fire, smoke, and toxic chemicals on Sept. 11, 2001, a new study shows.
Mouse Model of COVID-19–induced Lung Injury May Aid Development of Coronavirus Treatments
Article title: The SARS-CoV-2 spike protein subunit 1 induces COVID-19–like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells Authors: Ruben Colunga Biancatelli, Pavel Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul Ellis Marik, John…
A new treatment that might keep COVID-19 patients off the ventilator
A new treatment is among the first known to reduce the severity of acute respiratory distress syndrome caused by the flu in animals, according to a new study.
Newly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…
Protecting lungs from ventilator-induced injury
An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists are working to boost a natural cellular process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators.
Bacterial Extracellular Vesicles from Poultry Farm Dust Causes Lung Inflammation in Mice
Article title: Bacterial extracellular vesicles isolated from organic dust induce neutrophilic inflammation in the lung Authors: Velmurugan Meganathan, Regina Moyana, Kartiga Natarajan, Weshely Kujur, Shilpa Kusampudi, Sachin Mulik, Vijay Boggaram From the authors: “In summary, our studies have found that…
Breathing problems in teens: COVID-19 or lung injury due to vaping?
In a case series of three teen patients, UC Davis Health pediatricians present the common manifestations of COVID-19 and lung injury due to vaping (EVALI). As EVALI and COVID-19 share many symptoms, it is critical for health providers to get the vaping history of teenagers with unexplained breathing problems.
Aging Limits Lung Cells’ Ability to Regenerate after Injury
A new study in mice explores the effect of aging on the regenerative properties of lung cells after lung injury. The study is published in the American Journal of Physiology-Lung Cellular and Molecular Physiology. It was chosen as an APSselect article for November.
Tear Gas Use During COVID-19 Pandemic Irresponsible; Moratorium Needed, Says American Thoracic Society
The American Thoracic Society calls for a moratorium on the use of tear gas and other chemical agents deployed by law enforcement against protestors participating in demonstrations, including current campaigns sparked by the death of George Floyd.
#CDC Follow-up to Guide on #EVALI Expected Dec. 20; Guidance for Safe Discharge Planning
Don Hayes, Jr., MD, is the medical director of the Advanced Lung Disease Program and the Lung and Heart-Lung Transplant Programs at Nationwide Children’s Hospital. Dr. Hayes was one of the American Thoracic Society members who collaborated with the CDC…
Think Twice About Vaping
With the nationwide outbreak of vaping-related lung injuries, now is the time to learn the facts about e-cigarette use among kids and young adults.
Expert Available to Discuss Dangers of Vaping and Associated Lung Illness
WHO: Keith S. Naunheim, MD, Vallee L. Melba Willman Professor and Chief of Cardiothoracic Surgery at Saint Louis University (SLU); past president of The Society of Thoracic Surgeons WHY: The U.S. Food and Drug Administration and the U.S. Centers for…
@atscommunity members join #CDC to craft guidance on #vaping associated lung injury. Available for comment.
Don Hayes, Jr., MD, MS, MEd, is the medical director of the Advanced Lung Disease Program and the Lung and Heart-Lung Transplant Programs at Nationwide Children’s Hospital. He is a Professor of Pediatrics, Internal Medicine, and Surgery at The Ohio…