Blocking Protein in Mouse Lung Cells May Prevent or Heal Lung Injury

Article title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b

Authors: Ian Rochford, Jagdish Chandra Joshi, Sheikh Rayees, Mumtaz Anwar, Md Zahid Akhter, Lakshmi Yalagala, Somenath Banerjee, Dolly Mehta

From the authors: “Owing to the pivotal role of PDE4b in monocyte differentiation, we suggest that inhibition of PDE4b in [alveolar macrophages] is a potentially useful approach for the rapid generation of anti-inflammatory [alveolar macrophages] that subsequently prevent or resolve [acute lung injury].”

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.