Researchers Look to Deleted Mitochondrial Protein to Treat Heart Disease

Article title: Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome

Authors: Jessica N. Peoples, Nasab Ghazal, Duc M. Duong, Katherine R. Hardin, Janet R. Manning, Nicholas T. Seyfried, Victor Faundez, Jennifer Q. Kwong

From the authors: “Together, our results position acylations as an arm of the mitochondrial response to energy dysfunction and suggest a mechanism by which focal disruption to the energy production machinery can have an expanded impact on global mitochondrial function.”

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.