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UrduA phase 2 trial of a monoclonal antibody known as tulisokibart for moderate-to-severe ulcerative colitis (UC) showed promising results for those who have not responded to conventional inflammatory bowel disease (IBD) treatment. The results were reported Thursday, September 26, in The New England Journal of Medicine.
Tag: irritable bowel disease
Oral Probiotic Delivers Colitis Treatment Directly to Gut in Multiple Animal Models
Article title: Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models Authors: Emelie Öhnstedt, Cristian Doñas, Kristel Parv, Yanhong Pang, Hava Lofton Tomenius, Macarena Carrasco López, Venkata Ram Gannavarapu, Jacqueline Choi, Maria Ovezik, Peter Frank, Margareth…
Mount Sinai Launches the Brain and Body Research Center, Among the First in the U.S.to Focus Solely on How the Brain and Body Interact
Have you ever experienced a stressful time in your life and then caught a cold, or wondered why you feel sad and depressed when you’re sick? It turns out that it’s not all in your head.
Recent research spanning the fields of neuroscience and immunology suggests that when the brain senses a threat in the environment—whether it be physical, psychological, or social—it sends signals via a complex network of peripheral nerves that mobilize the immune system, readying it to protect us from injury.
Irritable Bowel Syndrome: Mark Pimentel, MD
Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting 10-15% of the world’s population. Approximately two-thirds of those who suffer from IBS are women. The disease can have mild forms or cause severe debilitation as diarrhea alternates with constipation. Severe cramping and bloating also are common. Because chronic IBS is so debilitating, it often disrupts the daily lives of people with this disorder.
Mount Sinai Researchers Investigate COVID -19 Biology, Describe Receptors in Intestinal Tract
In a study published today in Gastroenterology, researchers with the Icahn School of Medicine at Mount Sinai describe their investigation into two key aspects of COVID-19 biology in their study of the intersection between COVID-19, intestinal inflammation, and inflammatory bowel…
Yes, inflammatory bowel disease and celiac disease are linked
A systematic review and meta-analysis has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease. Similarly, the risk for celiac disease is increased in IBD patients, though to a smaller extent.
Mount Sinai Researchers Unveil Mechanisms to Prevent Crohn’s Disease and First Study Linking Metals Exposure w/ IBD
In a series of four studies published today in Gastroenterology, a journal of the American Gastroenterological Association, Mount Sinai inflammatory bowel disease (IBD) researchers, describe the identification of predictive tools and a new understanding of environmental factors that trigger IBD.