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UrduScientists have broken the rules of enzyme engineering to unlock a new method for creating chemical reactions that could unlock a wide range of new applications – from creating new drugs to food production. In their paper published today in…
Tag: PHARMACEUTICAL/COMBINATORIAL CHEMISTRY
New therapy for flu may help in fight against COVID-19
WEST LAFAYETTE, Ind. – A new therapy for influenza virus infections that may also prove effective against many other pathogenic virus infections, including HIV and COVID-19, has been developed by Purdue University scientists. In an average year, more than 2…
Understanding frustration could lead to better drugs
Rice scientists’ atomic resolution protein models reveal new details about protein binding
Tarantula toxin attacks with molecular stinger
Venom immobilizes prey by interfering with sodium channels that generate electrical signals in the animal’s nerve cells
A sulfur molecule to block the coronavirus
Some viruses can get inside cells via a mechanism that involves sulfur organic molecules. Chemists at UNIGE have discovered effective inhibitors and blocked the uptake of SARS-CoV-2.
More than 1.1 million deaths among Medicare recipients due to high cost of drugs
ore than 1.1 million Medicare patients could die over the next decade because they cannot afford to pay for their prescription medications, according to a new study released today by the West Health Policy Center, a nonprofit and nonpartisan policy research group and Xcenda, the research arm of the drug distributor AmerisourceBergen.
More than 1.1 million deaths among Medicare recipients due to high cost of drugs
Beneficiaries skipping medications is causing early death and worsening medical conditions that will cost Medicare an extra $177.4 billion over the next 10 years
Machine learning innovation to develop chemical library
One-step multicomponent reaction with interpretable machine learning innovation to develop chemical library for drug discovery
A DNA-based nanogel for targeted chemotherapy
Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers reporting in ACS’ Nano Letters have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within…
Gold nanoparticles turn the spotlight on drug candidates in cells
Osaka University researchers report a combination of alkyne tags and surface-enhanced Raman scattering (SERS) microscopy for following the dynamics of small-molecule drugs in cells
Merck KGaA, Darmstadt, Germany to deploy Insilico Medicine’s Chemistry42 AI platform
Insilico Medicine announces the first deployment of its flagship generative chemistry AI platform for de novo molecular design, Chemistry42™ on Merck KGaA, Darmstadt, Germany’s high-performance computing infrastructure
Killing cancer naturally: New process to produce compounds with anti-cancer properties
Scientists have uncovered a method of combining natural organic compounds which can create anticancer drugs with minimal side effects
New molecules derived from cannabidiol are designed with more potent antioxidants
Nowadays, cannabidiol is a star component, not only in the world of cosmetics, but also in pharmaceutics and nutrition due to its antioxidant properties and its therapeutical potential. It is a natural molecule that comes from medicinal cannabis and that,…
Personalized cancer vaccine clinical trial to expand following promising early results
A study led by University of Arizona Health Sciences researcher Dr. Julie Bauman that’s investigating a personalized cancer vaccine has reported a 50% response rate for patients with head and neck cancer in its preliminary data
Perspectives of infrared spectroscopy in quantitative estimation of proteins
This article by Dr. Rohit Bhatia and colleagues is published in Current Analytical Chemistry, 2020
Lighting the way to selective membrane imaging
Scientists at Kanazawa University demonstrate surface-specific molecular aggregates that emit visible light when attachment to artificial cell membrane surface with potential applications in new biological sensors and smart drug delivery platforms
New multicomponent reaction frontiers
An innovative protocol eases the synthesis of high structural complex molecules
In a hurry to develop drugs? Here’s your cHAT
Rice chemists pitch ‘green’ method for making pharmaceutical intermediates
Cleveland Clinic-led research team identifies differences between benign and pathogenic variants
CLEVELAND – An international team of researchers led by Cleveland Clinic’s Lerner Research Institute has performed for the first time a wide-scale characterization of missense variants from 1,330 disease-associated genes. Published in Proceedings of the National Academy of Sciences ,…
Computer vision helps find binding sites in drug targets
Scientists from the iMolecule group at Skoltech Center for Computational and Data-Intensive Science and Engineering (CDISE) developed BiteNet, a machine learning (ML) algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins. BiteNet can analyze 1,000 protein…
Rising opioid use during pandemic heightens need for safe drug disposal
UH Pharmacy professor receives $3.3 million grant for safe medication disposal education, research
Calcium bursts kill drug-resistant tumor cells
Multidrug resistance (MDR) — a process in which tumors become resistant to multiple medicines — is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of…
Machine learning model helps characterize compounds for drug discovery
WEST LAFAYETTE, Ind. – Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields. Now, Purdue University innovators have created a new method of applying machine learning concepts to the tandem…
DNA-peptide interactions create complex behaviours which may have helped shape biology
Researchers find that simple DNA-peptide interactions create a surprising diversity of compartmentalised higher-ordered phase behaviours, suggesting that these polymers’ primordial interactions helped create modern complex biological structures.
Design and test potential COVID-19 treatments from your phone
The ViDok app crowdsources the drug discovery process
RUDN University chemists developed a domino reaction for producing new antitumor drugs
A team of chemists from RUDN University suggested a new reaction to produce organic compounds in one vessel. The end products turned out to be effective against the cells of carcinomas, including drug-resistant ones. The new reaction was described in…
NIH award to fund UArizona research on opioid addiction and relapse in postpartum women
The $2.3 million National Institutes of Health grant enables University of Arizona College of Medicine Tucson’s Dr. Alicia Allen to explore how women’s hormones influence postpartum opioid relapse and if they can be used as a preventative strategy
Deep learning gives drug design a boost
Rice translator expands metabolite prediction of chemical reactions in the human body
Global Pharmaceutical Policy
The only text available today which provides an up to date account of international pharmaceutical policy research.
Planaria flatworms can be alternative screening tool to avoid rabbit skin testing
Tests for skin treatments could be screened using flatworms rather than other animals such as rabbits, according to new research. A team at the University of Reading and Newcastle University have found that planaria, a type of flatworm, can be…
Repurposed anti-malarial compounds kill diarrheal parasite, study finds
CHAMPAIGN, Ill. — A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new…
A single-application treatment for ear infections that doesn’t need refrigeration
Outer ear infections, which affect millions of people each year, are typically caused by the bacteria Pseudomonas aeruginosa or Staphylococcus aureus . Repeatedly administering antibiotic drops, the standard treatment, can be a problem for some people, and the only single-use…
Common antioxidant enzyme may provide potential treatment for COVID-19
Researchers from UCLA and China have found that catalase, a naturally occurring enzyme, holds potential as a low-cost therapeutic drug to treat COVID-19 symptoms and suppress the replication of coronavirus inside the body. A study detailing the research was published…
Facile synthesis of quinoline in water
The article by Dr. Bimal Banik and colleagues is published in Current Organic Chemistry, 2020
Microwaves are useful to combine amino acids with hetero-steroids
The article by Dr. Bimal Banik and colleagues is published in Current Organic Synthesis, 2020
Ascorbic acid-mediated reactions in organic synthesis
This article by Dr. Bimal Krishna Banik and colleagues is published in Current Organocatalysis, 2020
Opening an autophagy window as the apoptosis door starts to close
Tokyo – Many people across the globe are working hard to get the better of cancer; however cancer is always working too. Cancer cells can become resistant to the methods that have been adopted to kill them, so identifying drugs…
Lending color to dead cells — A novel natural dye for screening cell viability
Scientists discover a natural food pigment that can distinguish between living and dead cells in cell cultures
New drug candidate found for hand, foot and mouth disease
Targeting RNA with small molecules could pave the way for new antivirals
October issue SLAS Technology now available
October Issue SLAS Technology Features Cover Article, “Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable” Oak Brook, IL – The October issue of SLAS Technology features the cover article, “Role of Digital Microfl-uidics in…
IU researchers receive grant to study potential new opioid addiction treatment
Researchers at Indiana University School of Medicine are testing use of tezampanel, a novel antagonist at glutamate receptors that could treat opioid withdrawal syndrome and other addictions and mental illnesses. The school recently received a $12.3 million grant from the…
Scientists updated genome editing technology
Researchers compared their developed carriers for delivery of genome editing (GE) tools with other available analogues.
Fish oil without the fishy smell or taste
Sustainable processing delivers highest quality, minimizing odor and taste, says UC researcher
Phasing out a microscope’s tricks
An instrument error can lead to complete misidentification of certain crystals, reports a KAUST study that suggests researchers need to exercise caution when using electron microscopes to probe two-dimensional (2D) semiconductors. 2D transition metal dichalcogenides (TMDs) are being tapped for…
Designed antiviral proteins inhibit SARS-CoV-2 in the lab
Computer design of synthetic proteins is creating potent, stable antivirals that block infection at least as well as monoclonal antibodies
Examining the side effects of Alzheimer’s disease dementia drugs
Goal: To improve quality of medication used in dementia
Pharma aims to make a better CBD
Cannabidiol (CBD) is an increasingly popular wellness trend. The compound, which occurs naturally in cannabis plants, is added to many products that claim to reduce anxiety, alleviate pain and more, without the intoxication of its cousin tetrahydrocannabinol (THC). While CBD…
Making more of methane
Demand continues for plastics and solvents made from petrochemicals, which are mainly produced by refining oil despite diminishing global oil reserves, driving forward the search for new ways to produce the chemicals we need. Methane is the main component of…
Portland State lab finds finds new levels of detail about key membrane proteins
Portland State University researchers used advanced electron microscopy to create a 3-D reconstruction of a membrane protein at an unprecedented level of resolution, setting the stage for the development of drugs that could target the protein more effectively to treat…
New Nitrogen Assembly Carbon catalyst has potential to transform chemical manufacturing
Scientists at the U.S. Department of Energy’s Ames Laboratory have discovered a metal-free carbon-based catalyst that has the potential to be much less expensive and more efficient for many industrial concerns, including manufacturing of bio- and fossil fuels, electrocatalysis, and…