A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the destruction of bone cells. The research identifies the HIF1α-HMOX1 axis as a critical pathway that induces excessive autophagy and iron overload, leading to osteocyte demise.
Tag: bone
Alcohol misuse can disrupt gut microbiota, causing inflammation that leads to organ damage
Alcohol researchers have long known that excessive drinking can cause damage to the liver, pancreas, heart, muscle, bone, and brain. However, only a subset of patients with alcohol use disorder (AUD) appear to develop organ damage. New research shows that alcohol-induced gut inflammation is the missing link between unhealthy drinking and organ damage among certain AUD patients.
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation
Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow and adipose tissue, and differentiate into various cell types, such as osteoblasts and adipocytes. Recent studies on MSCs have revealed that many transcrip
Implant shows extreme promise for regenerating bone
Its powers may not rival Wolverine’s, but a regenerative implant engineered by researchers at the University of Nebraska Medical Center and University of Nebraska–Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis.
‘Break a leg’ not so lucky when it leads to limb deformities
Orthopaedic researchers are one step closer to preventing life-long arm and leg deformities from childhood fractures that do not heal properly.
UChicago scientists invent material inspired by bone that can strengthen from vibration
Our bones adapt to strain and get stronger, and now robots could do the same. New research from Aaron Esser-Kahn demonstrates how a soft gel can become harder when exposed to vibration
NuShores Biosciences receives $2.8 million contract for intelligent manufacturing automation of bone regeneration technology
NuShores Biosciences, a spin-off company of the University of Arkansas at Little Rock, has received a three-year, $2.8 million contract from the Medical Technology Enterprise Consortium, a biomedical technology consortium associated with the U.S. Army Medical Research and Development Command. The contract will enable NuShores to develop intelligent automated production of its NuCress™ bone void filler scaffold products using its factory-in-a-box concept. Key collaborators on the project include UA Little Rock and MiQ Partners of Cincinnati.
NEW APPROACH TO TREATING OSTEOARTHRITIS ADVANCES
Injections of a natural “energy” molecule prompted regrowth of almost half of the cartilage lost with aging in knees, a new study in rodents shows.
Hackensack Meridian Health Invests in EpiBone, Inc., A Regenerative Medicine Company
EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.
Hydrogel Offers Double Punch Against Orthopedic Bone Infections
Surgery prompted by automobile accidents, combat wounds, cancer treatment and other conditions can lead to bone infections that are difficult to treat and can delay healing until they are resolved. Now, researchers have a developed a double-duty hydrogel that both…