Melanoma metastasis: unveiling the ferroptosis pathway in bone

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the destruction of bone cells. The research identifies the HIF1α-HMOX1 axis as a critical pathway that induces excessive autophagy and iron overload, leading to osteocyte demise.

Alcohol misuse can disrupt gut microbiota, causing inflammation that leads to organ damage

Alcohol researchers have long known that excessive drinking can cause damage to the liver, pancreas, heart, muscle, bone, and brain. However, only a subset of patients with alcohol use disorder (AUD) appear to develop organ damage. New research shows that alcohol-induced gut inflammation is the missing link between unhealthy drinking and organ damage among certain AUD patients.

NuShores Biosciences receives $2.8 million contract for intelligent manufacturing automation of bone regeneration technology

NuShores Biosciences, a spin-off company of the University of Arkansas at Little Rock, has received a three-year, $2.8 million contract from the Medical Technology Enterprise Consortium, a biomedical technology consortium associated with the U.S. Army Medical Research and Development Command. The contract will enable NuShores to develop intelligent automated production of its NuCress™ bone void filler scaffold products using its factory-in-a-box concept. Key collaborators on the project include UA Little Rock and MiQ Partners of Cincinnati.

Hydrogel Offers Double Punch Against Orthopedic Bone Infections

Surgery prompted by automobile accidents, combat wounds, cancer treatment and other conditions can lead to bone infections that are difficult to treat and can delay healing until they are resolved. Now, researchers have a developed a double-duty hydrogel that both…