Tag: Amyotrophic Lateral Sclerosis (Als)

Decoding the influence of mitochondrial Ca2+ regulation on neurodegenerative disease progression

sarah JonasResearch Results

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes like ATP production and pathophysiological events, including cell death and cancer. The balance of Ca2+ uptake and efflux, mediated by mitochondrial transporters and mitochondria-endoplasmic reticulum contact sites (MERCS), is essential for maintaining Ca2+mito homeostasis. This review summarizes current insights into mitochondrial Ca2+ regulation, its roles in physiology and neurodegenerative diseases, and explores therapeutic strategies targeting Ca2+ homeostasis, including innovative drug delivery systems and calcium-modulating agents.

Ileana Howard, MD, Selected to Speak at the 2024 AANEM Annual Meeting

sarah JonasAnnouncement

The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM), is excited to announce Ileana Howard, MD, as a plenary speaker at the 2024 AANEM Annual Meeting Oct. 15-18, in Savannah, Georgia.

UC Irvine-led research team builds first tandem repeat expansions genetic reference maps

sarah JonasResearch Results

A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington’s disease and multiple cancers.

UM School of Medicine Brain and Tissue Bank to Receive $800,000 to Expand Research Initiatives and Outreach on Amyotrophic Lateral Sclerosis (ALS)

sarah JonasAnnouncement

The University of Maryland School of Medicine (UMSOM) will receive an $800,000 donation to be used by the University of Maryland Brain and Tissue Bank to advance research into the treatment and cure of Amyotrophic Lateral Sclerosis (ALS), commonly referred to as Lou Gehrig’s Disease.

First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting

sarah JonasResearch Tip Sheet

Investigators from Cedars-Sinai will present the latest novel stem cell and regenerative medicine research at the International Society for Stem Cell Research (ISSCR) Annual Meeting, which is being held in person and virtually June 15-19 in San Francisco.

Researchers link neurodegenerative disease protein to defective cholesterol metabolism

sarah JonasResearch Results

Researchers in Singapore have discovered that brain cells cannot maintain the cholesterol-rich myelin sheath that protects and insulates neurons in the absence of a protein called TDP-43. The study, which will be published August 4 in the Journal of Cell Biology (JCB), suggests that restoring cholesterol levels could be a new therapeutic approach for diseases associated with TDP-43, such as amyotrophic lateral sclerosis and frontotemporal dementia.