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UrduNipah virus, which is transmitted to humans from bats and pigs, has a high mortality rate and there are no licensed drugs against it. Now, researchers have used information on the structure of the Nipah virus to identified 150 possible…
Tag: Molecular Biology
Virus multiplication in 3D
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host’s nucleus can they find the machines, enzymes and building blocks with which they can multiply their genetic material before…
Understanding Asteraceae: Validation of a Hyb-Seq probe set for evolutionary studies
Accurately reconstructing the relationships between different species requires analyzing the sequences of a judiciously selected, and preferably large, sample of different genes. Hybrid capture with high-throughput sequencing, or Hyb-Seq, is a powerful tool for obtaining those gene sequences, but must…
Princeton researchers listen in on the chemical conversation of the human microbiome
Princeton researchers have developed new computational and experimental tools to identify microbial small molecules encoded in clinical samples, allowing scientists to explore microbial-host interactions and to mine the human microbiome for drug discovery
Australian and US team discover new human autoinflammatory disease
Scientists from Australia and the US have discovered and identified the genetic cause of a previously unknown human autoinflammatory disease. The researchers determined that the autoinflammatory disease, which they termed CRIA (cleavage-resistant RIPK1-induced autoinflammatory) syndrome, is caused by a mutation…
Princeton researchers listen in on the chemical conversation of the human microbiome
Princeton researchers have developed new computational and experimental tools to identify microbial small molecules encoded in clinical samples, allowing scientists to explore microbial-host interactions and to mine the human microbiome for drug discovery
Australian and US team discover new human autoinflammatory disease
Scientists from Australia and the US have discovered and identified the genetic cause of a previously unknown human autoinflammatory disease. The researchers determined that the autoinflammatory disease, which they termed CRIA (cleavage-resistant RIPK1-induced autoinflammatory) syndrome, is caused by a mutation…
A machine learning approach to identify functional human phosphosites
New resource for identifying functional human phosphosites relevant for diverse biological processes and disease
Single-cell analysis of the earliest cell fate decisions in development
Multi-omics analysis of the process establishing the mammalian body plan
Modifier Gene May Explain Why Some with Cystic Fibrosis are Less Prone to Infection
People with cystic fibrosis who carry genetic variants that lower RNF5 gene expression have more mutant CFTR protein on cell surfaces. Even if the CFTR protein isn’t fully functional, it’s better than none, and may explain why some with cystic fibrosis are less prone to infection than others.
Deep learning helps tease out gene interactions
New method could help identify disease-related genes, pathways
Scientists accidentally discover a new water mold threatening Christmas trees
Grown as Christmas trees, Fraser firs are highly prized for their rich color and pleasant scent as well as their ability to hold their needles. Unfortunately, they are also highly susceptible to devastating root rot diseases caused by water molds…
Increasing food intake by swapping mitochondrial genomes
Many of the characteristics that make people so different from each other, are often the result of small differences in the DNA between individuals. Variation in just a single base in our DNA can cause significant variation in traits like…
Liquid flow is influenced by a quantum effect in water
Water is the basis of all life on earth. Its structure is simple – two hydrogen atoms bound to one oxygen atom – yet its behavior is unique among liquids, and scientists still do not fully understand the origins of…
New clues to the link between ALS and type 2 diabetes
Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has since long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular mechanism linking these two diseases. The study is published…
Scientists accidentally discover a new water mold threatening Christmas trees
Grown as Christmas trees, Fraser firs are highly prized for their rich color and pleasant scent as well as their ability to hold their needles. Unfortunately, they are also highly susceptible to devastating root rot diseases caused by water molds…
Award to create clinical solution for life-threatening preemie condition
The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health has awarded Chosen Diagnostics Inc, a spin-out company, a $299,641 Phase I Small Business Technology Transfer award. Based on an LSU Health…
Increasing food intake by swapping mitochondrial genomes
Many of the characteristics that make people so different from each other, are often the result of small differences in the DNA between individuals. Variation in just a single base in our DNA can cause significant variation in traits like…
Liquid flow is influenced by a quantum effect in water
Water is the basis of all life on earth. Its structure is simple – two hydrogen atoms bound to one oxygen atom – yet its behavior is unique among liquids, and scientists still do not fully understand the origins of…
New clues to the link between ALS and type 2 diabetes
Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has since long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular mechanism linking these two diseases. The study is published…
Award to create clinical solution for life-threatening preemie condition
The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health has awarded Chosen Diagnostics Inc, a spin-out company, a $299,641 Phase I Small Business Technology Transfer award. Based on an LSU Health…
Ancient worm reveals way to destroy toxic cells in Huntington’s disease
Insights from their study may provide a novel therapeutic approach for diseases such as Huntington’s and Parkinson’s. Associate Professor Roger Pocock, from the Monash Biomedicine Discovery Institute (BDI), and colleagues from the University of Cambridge led by Professor David Rubinsztein,…
Scientists have spotted new compounds with herbicidal potential from sea fungus
Scientists of Far Eastern Federal University (FEFU) and the G.B. Elyakov Pacific Institute of Bioorganic Chemistry (FEB RAS) together with German colleagues spotted six new and three already known biologically active compounds in a new strain of the fungus Penicillium…
‘Conductor’ gene found in plant root stem cell ‘orchestra’
In a new paper, researchers at North Carolina State University lift the veil on the “conductor” plant root stem cell gene that helps orchestrate and coordinate stem cell division of different root stem cell types, ensuring the harmonic communication necessary…
Discovery of a new protein gives insight into a long-standing plant immunity mystery
When a plant senses an invading pathogen, it activates a molecular signaling cascade that switch on its defense mechanisms. One such mechanism involves sacrificing host cells to the pathogen. This is a tightly controlled process that involves the work of…
Scientist identify new marker for insecticide resistance in malaria mosquitoes
Researchers at LSTM have genetically modified malaria carrying mosquitoes in order to demonstrate the role of particular genes in conferring insecticide resistance. For the first time the team characterised three genes (Cyp6m2, Cyp6p3 and Gste2) most often associated with insecticide…
Recruitment of miR-8080 by luteolin inhibits AR-V7 in castration-resistant prostate cancer
MiR-8080 inhibits AR-V7 and CRPC
Scientist identify new marker for insecticide resistance in malaria mosquitoes
Researchers at LSTM have genetically modified malaria carrying mosquitoes in order to demonstrate the role of particular genes in conferring insecticide resistance. For the first time the team characterised three genes (Cyp6m2, Cyp6p3 and Gste2) most often associated with insecticide…
Recruitment of miR-8080 by luteolin inhibits AR-V7 in castration-resistant prostate cancer
MiR-8080 inhibits AR-V7 and CRPC
Alzheimer’s Drug Discovery Foundation’s Diagnostics Accelerator announces second round of awards
$50 million global research initiative, funded by Leonard A. Lauder, Bill Gates, Jeff and MacKenzie Bezos, among other leading philanthropists, targets resources to speed up development of blood, digital and other biomarkers for early detection
Alzheimer’s Drug Discovery Foundation’s Diagnostics Accelerator announces second round of awards
$50 million global research initiative, funded by Leonard A. Lauder, Bill Gates, Jeff and MacKenzie Bezos, among other leading philanthropists, targets resources to speed up development of blood, digital and other biomarkers for early detection
New approach to treating cystic fibrosis could lower risk of lung transplants and death
A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death. The study, led by researchers at RCSI…
How accumulating useful genes helps older yeast fare better in tougher times
Satellite DNA circles allow genome flexibility in challenging environments
Dramatic transition in Streptomyces life cycle explained in new discovery
Streptomyces bacteria are our primary source of antibiotics, which are produced in the transition from vegetative growth to sporulation in a complex developmental life cycle. Previous research by Professor Mark Buttner’s lab at the John Innes Centre has shown that…
EMBO welcomes first Global Investigators
Nine life scientists join the new EMBO Programme in its first year
Raising plants to withstand climate change
Proof of concept for changing mitochondrial respiration
New approach to treating cystic fibrosis could lower risk of lung transplants and death
A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death. The study, led by researchers at RCSI…
How accumulating useful genes helps older yeast fare better in tougher times
Satellite DNA circles allow genome flexibility in challenging environments
Dramatic transition in Streptomyces life cycle explained in new discovery
Streptomyces bacteria are our primary source of antibiotics, which are produced in the transition from vegetative growth to sporulation in a complex developmental life cycle. Previous research by Professor Mark Buttner’s lab at the John Innes Centre has shown that…
EMBO welcomes first Global Investigators
Nine life scientists join the new EMBO Programme in its first year
Raising plants to withstand climate change
Proof of concept for changing mitochondrial respiration
Cell-free synthetic biology comes of age
Cell-free systems stand to dramatically impact society, from the environment to medicine to education
EMBL and Leica sign open innovation collaboration agreement
EMBL often cooperates with industry partners, and has cooperated successfully with Leica for many years. Based on this strong partnership, Leica is among the companies supporting the upcoming EMBL Imaging Centre, which is currently under construction at the EMBL campus…
Designing and repurposing cell receptors
Called the “second secret of life”, allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development. But what is allostery? In…
Protein defect leaves sperm chasing their tails
A team led by researchers from Osaka University identify a protein required for electrical signal sensing, which, when defective, causes sperm to swim in circles
Researchers at IRB Barcelona study how altered protein degradation contributes to the development of tumors
To understand the molecular bases of cancer, it is imperative to determine the genetic alterations responsible for the development and spread of this condition and to identify the mechanisms through which healthy cells become malignant. In the last twenty years,…
New clues about the origins of familial forms of Amyotrophic lateral sclerosis
A team led by Brazilian researcher Elis Eleutherio, professor at the Federal University of Rio de Janeiro, in partnership with Tiago Outeiro, at University of Goettingen, Germany, made important progress in understanding the conformation and accumulation of certain proteins involved…
Oat pathogen defence discovery marks an important milestone
Researchers have identified the critical last pieces of a genetic defence system that gives oats resistance to soil pathogens. The discovery opens significant opportunities for scientists and breeders to introduce versions of this defence mechanism into other crops. It is…
Scientists reveal the structure of viral rhodopsins
The structure of an Organic Lake Phycodnavirus rhodopsin II (OLPVRII), which is a unique protein found in the genome of giant viruses, has been determined thanks to the work of MIPT graduates and PhD students. The paper was published in…
Anthracnose alert: How bacteria prime fifth-biggest global grain crop against deadly fungus
Anthracnose of Sorghum bicolor devastates crops of the drought- and heat-resistant cereal worldwide. Priming with rhizobacteria can boost the plants’ resistance and tolerance against a wide range of adverse conditions such as microbial attacks. University of Johannesburg researchers decoded how…