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Tag: genes
Role of subnuclear NSrp70 in immunity-studied at Gwangju Institute of Science & Technology
Scientists report that the alternative-splicing regulator NSrp70 influences immune T cell development
The path(way) less traveled in DNA double-strand break repair
Researchers from Osaka University find that protein phosphatase 1 helps protect the ends of double-strand DNA breaks to promote their repair through the non-homologous end joining pathway
Long-term memory setup requires a reliable delivery crew
Synaptic plasticity depends on molecular hauler KIF5C, carrier of more than 650 RNAs, study finds
A common ancestor for cells involved in hearing and touch
USC Stem Cell scientists point to developmental and evolutionary similarities between sensory cells in the inner ear and the skin
New technique reduces nicotine levels, harmful compounds simultaneously in tobacco
North Carolina State University researchers have developed a new technique that can alter plant metabolism. Tested in tobacco plants, the technique showed that it could reduce harmful chemical compounds, including some that are carcinogenic. The findings could be used to…
Genetic analysis to help predict sunflower oil properties
Skoltech researchers and their colleagues from the University of Southern California have performed genetic analysis of a Russian sunflower collection and identified genetic markers that can help predict the oil’s fatty acid composition. The research was published in BMC Genomics.…
Genome editing for food: how do people react?
Research team from the Universities of Göttingen and British Columbia investigates evaluations of breeding technology
Using genomics to save the bees
2021 Agricultural Greater Good Grant awarded to Göttingen University molecular biologist
Sweet success: CABBI demonstrates first precision breeding of sugarcane with CRISPR-Cas9
Gene-editing offers a targeted, efficient way to develop new varieties of this productive but complex plant
Match matters: The right combination of parents can turn a gene off indefinitely
UMD scientists discover that mating can cause epigenetic changes in nematode worms that last for 300 generations
Discovery of a mechanism for efficient autophagosome formation
Revealing the molecular role of the most famous autophagy factor
Research reveals structure of nanomachine that assembles a cell’s energy control system
Sussex researchers have determined the structure of a tiny multi-protein biological machine, furthering our understanding of human cells and helping to enhance research into cancer, neurodegeneration and other illnesses
New Alzheimer’s treatment targets identified
Study points to FDA-approved drugs that have potential to slow or reverse brain damage
Cell-type-specific insight into the function of risk factors in coronary artery disease
Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin…
Genetic analysis technique finds missing link between thyroid function and lipid profile
Using a genetic analysis called Mendelian randomization, researchers suggest causal association between thyroid function and serum lipid profiles
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Scientists at the University of Cambridge have identified rare genetic variants – carried by one in 3,000 people – that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect. Type 2…
Next generation cytogenetics is on its way
Does optical genome mapping turn cytogenetics upside down?
New generation anti-cancer drug shows promise for children with brain tumours
A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University…
New generation anti-cancer drug shows promise for children with brain tumors
A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University…
Protein’s ‘silent code’ affects how cells move
A University of Pennsylvania-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences
Leonardo Da Vinci: New family tree spans 21 generations, 690 years, finds 14 living male descendants
Paper offers foundation to advance search for Leonardo’s DNA
Relationship between chromosomal instability and senescence revealed in the fly Drosophila
Chromosomal instability is a feature of solid tumours such as carcinoma. Likewise, cellular senescence is a process that is highly related to cellular ageing and its link to cancer is becoming increasingly clear. Scientists led by ICREA researcher Dr. Marco…
Muscles retain positional memory from fetal life
New perspectives on the pathological mechanisms of muscle diseases and regenerative medicine development
Memory making involves extensive DNA breaking
The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations–more than previously realized, according to a new study–to provide quick…
Personalized medicine for cats with heart disease
Study finds genetic makeup influences response to common feline heart disease medication
Could genetics hold the key to preventing SIDS?
A state-of-the-art genetic biobank could hold the key to preventing Sudden Infant Death Syndrome (SIDS), potentially saving the lives of hundreds of babies who die from the devastating condition each year. Developed by the University of South Australia, the biobank*…
Three-in-one approach boosts the silencing power of CRISPR
A newly developed CRISPR-Cas9-based tool carries out efficient and long-term gene silencing by epigenetic editing
New approach can add diversity to crop species without breeding GMOs
Genetic technique edits every chloroplast in a plant, but does not change nuclear DNA of offspring
Spatial patterns of gene transcripts captured across single cells of mouse embryo
Sci-space could help construct mammal embryonic development atlases that map gene expression over time and location at single-cell resolution
How information beyond the genetic sequence is encoded in plant sperm
Hereditary information is passed from parent to offspring in the genetic code, DNA, and epigenetically through chemically induced modifications around the DNA. New research from the John Innes Centre has uncovered a mechanism which adjusts these modifications, altering the way…
Turning yeast cells into labs for studying drivers of gene regulation
Researchers have developed a more efficient platform for studying proteins that play a key role in regulating gene expression. The approach uses engineered yeast cells to produce enzyme and histone proteins, conduct biochemical assays internally, and then display the results.…
Folate deficiency demystified — why some people may be at a greater risk of disease
As many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be a life-long struggle which can…
Digging into the molecules of fossilized dinosaur eggshells
Dinosaurs roamed the Earth more than 65 million years ago, and paleontologists and amateur fossil hunters are still unearthing traces of them today. The minerals in fossilized eggs and shell fragments provide snapshots into these creatures’ early lives, as well…
Small-scale engineering could bring big progress in medical care
Effective diagnostics, therapies and treatments for diseases and infections could increasingly involve re-engineering the body’s internal biomechanisms at their most basic chemical and molecular foundations. Growing knowledge about the body’s biological processes is increasing the possibilities for restoring human health,…
‘Genomics of Rare Diseases. Understanding Disease Genetics Using Genomic Approaches’
In 2018, Dr. Claudia Gonzaga-Jáuregui, who years before had completed her doctorate studies in Dr. James R. Lupski’s lab at Baylor College of Medicine, received an email from an editor at Elsevier’s Academic Press with a proposal that immediately caught…
Cardiac atrophy findings may set course for preventing harm from long space flights
Team led by scientists at Cincinnati Children’s discover molecular process behind dangerous loss of heart muscle
Testing several genes can lead to better effect of medicinal products
Most of us have genetic variations that increase the risk of medicinal products not being effective. In order to provide a more effective treatment with fewer side effects, we need to analyse more of these genetic variations. This will provide…
Rap1 controls the body’s sugar levels from the brain
Managing type 2 diabetes typically involves losing weight, exercise and medication, but new research by Dr. Makoto Fukuda and colleagues at Baylor College of Medicine and other institutions suggests that there may be other ways to control the condition through…
Running in the blood: Blood lipids are linked to cancer, but depending on family history
Medical researchers identify the role of family history in the link between blood lipids and esophageal cancer
Study identifies trigger for ‘head-to-tail’ axis development in human embryo
Scientists have identified key molecular events in the developing human embryo between days 7 and 14 – one of the most mysterious, yet critical, stages of our development. The second week of gestation represents a critical stage of embryo development,…
Mutant genes can promote genetic transfer across taxonomic kingdoms
Bacteria do not sexually reproduce, but that does not stop them from exchanging genetic information as it evolves and adapts. During conjugal transfer, a bacterium can connect to another bacterium to pass along DNA and proteins. Escherichia coli bacteria, commonly…
Foresight diagnostics to show vision of the new standard of lymphoma MRD detection at ICML
AURORA, COLORADO, June 16, 2021 — Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the…
Beyond mere blueprints: Variable gene expression patterns and type 1 diabetes
A recently published review explores the role of epigenetic factors in the development and progression of type 1 diabetes
Natural killers: Using the body’s cells to target breast cancer
Study lays groundwork for possible new immunotherapy for the world’s most commonly diagnosed cancer
CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy
The PrimPol protein helps the cell to survive the damage caused by chemotherapy; the researchers want to make tumor cells more sensitive to cancer treatments by repressing PrimPol
A ‘pump’ gene’s surprising role in early brain formation
A mutation in four children with polymicrogyria illuminates the role of bioelectricity in early brain development
Reference genome comparison finds exome variant discrepancies in 206 genes
HOUSTON – (June 14, 2021) – In the two decades since the Human Genome Project mapped the entire human genome, improvements in technology have helped in developing updated reference genomes used for sequencing. But while the GRCh38 (hg38) human reference…
Understanding the cause of joint and tendon dysfunction in osteogenesis imperfecta
HOUSTON – (June 14, 2021) – Osteogenesis imperfecta (OI) is the most common genetic form of brittle bone disease and results in defects of both bone and connective tissue. OI patients can have significant problems with mobility due to joint…
USC study reveals potential new treatment target for Alzheimer’s disease
Researchers at Keck School of Medicine of USC identify a novel target related to the blood-brain barrier and a potential therapy that offers hope for slowing progression of Alzheimer’s disease in people with the APOE4 gene