Loss of protein disturbs intestinal homeostasis and can drive cancer

Colorectal carcinoma (CRC), the most common form of intestinal cancer, is the second leading cause of cancer related death worldwide. While some patients have a genetic predisposition to the disease, the majority of cases are sporadic and largely influenced by…

Solving obesity: Could manipulating microbes offer an alternative to weight loss surgery?

Already considered a global epidemic, human obesity continues to be on the rise. According to the Centers for Disease Control, more than 40% of the U.S. population is considered obese. The gamut of adverse health effects associated with obesity is…

March 2020 Issue of The American Journal of Gastroenterology Includes Complementary & Alternative Therapies for Functional GI Disorders

The March issue of The American Journal of Gastroenterology features evidence-based articles related to complementary and alternative medicine therapies for functional GI disorders, a new ACG Clinical Guideline for the diagnosis and management of Chronic Pancreatitis, opioid-related constipation, and more.

CHOP Researchers Develop Novel Approach to Capture Hard-to-View Portion of Colon in 3-D for the First Time

In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon – in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited clinical information.

Poop matters: Making the mouse gut microbiome more human-like

There is a growing consensus that the gut microbiome is involved in many aspects of physical and mental health, including the onset of Parkinson’s disease, multiple sclerosis, and even some behaviors. The microbiota of the small intestine in particular are…

Study: Bariatric surgeries can double peak blood alcohol levels, patients may be unaware

CHAMPAIGN, Ill. — A new study of 55 women found that two of the most popular forms of bariatric surgery – Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy – may dramatically change patients’ sensitivity to and absorption of alcohol. Some…

Poop matters: Making the mouse gut microbiome more human-like

There is a growing consensus that the gut microbiome is involved in many aspects of physical and mental health, including the onset of Parkinson’s disease, multiple sclerosis, and even some behaviors. The microbiota of the small intestine in particular are…

Study: Bariatric surgeries can double peak blood alcohol levels, patients may be unaware

CHAMPAIGN, Ill. — A new study of 55 women found that two of the most popular forms of bariatric surgery – Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy – may dramatically change patients’ sensitivity to and absorption of alcohol. Some…