Although various image-based central position estimation (termed “centroid fitting”) methods such as 2D Gaussian fitting methods have been commonly used in single-molecule localization microscopy (SMLM) to precisely determine the location of each fluorophore, it is still a challenge to improve…
Tag: Biology
Overcoming resistance in pancreatic cancer
Cold Spring Harbor, NY — Cancer is relentless and resilient. When a drug blocks a cancer cell’s main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called “developing resistance,”…
How brain rhythms organize our visual perception
A team of neuroscientists from Göttingen and Tehran shows how our brain combines visual features to
Identity crisis for fossil beetle helps rewrite beetle family tree
There are more different kinds of beetle than just about any other kind of animal–scientists have described about 5,800 different species of mammals, compared with nearly 400,000 species of beetles. Of those 400,000 kinds of beetles, more than 64,000 species…
Frontier research boosted by international commitment to top science
The Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Ministry of Economy, Trade and Industry (METI), and the Japan Agency for Medical Research and Development (AMED) of Japan hosted the 2019 Triennial Conference of HFSPO Members (TCHM) to…
Zika virus infects the adult human brain and causes memory deficits in animal models
Brazilian researchers found the cause of neurological complications observed in adults patients infe
Underrated and underground, tuber evolution study earns NSF grant
EAST LANSING, Mich – The United States grew more than a million acres of potatoes in 2017, making the number one vegetable crop in the country a tuber. But potatoes are not the only tubers. Jerusalem artichoke, potato bean and…
Discovery of neuronal ensemble activities that is orchestrated to represent one memory
Success in observing how memory is consolidated in brain during sleep
Helminthic infections may be beneficial against HIV-1
Infection with parasitic helminths can reduce the susceptibility of T-cells to HIV-1 infection, according to a study published September 5 in the open-access journal PLOS Pathogens by Esther de Jong of the University of Amsterdam and William Paxton of the…
SPEECHLESS, SCREAM and stomata development in plant leaves
The key step in stomata development in plants has been discovered; genes that make stomata and enfor
New research discovers the financial cost of trachoma surveys
Impact surveys critical to tracking bacterial disease that causes blindness
Cataloguing the human impact on the world’s oceans
Norwegian researcher awarded European Research Council grant to explore the ocean’s many woes
Source water key to bacterial water safety in remote Northern Australia
In the wet-dry topics of Australia, drinking water in remote communities is often sourced from groundwater bores. The geochemistry of that groundwater impacts the occurrence of opportunistic pathogens in the drinking water supply, researchers now report in PLOS Neglected Tropical…
Size matters: How cells pack in epithelial tissues
KANSAS CITY, MO–Small-cell clones in proliferating epithelia – tissues that line all body surfaces – organize very differently than their normal-sized counterparts, according to a recent study from the Stowers Institute for Medical Research. Published online September 5, 2019, in…
Time saving software in an age of ever-expanding data
It is hard to get people excited about research software says Eliza Grames, a PhD candidate in ecology and evolutionary biology. Yet, the software she has developed is exciting and to understand why, it is important to put yourself into…
UB and IRBio experts sequence the genome of an endemic spider from the Canary Islands
A ravening predator in the Canary laurel forests
The paradox of different house flies with few genetic differences
UH evolutionary biologist publishes findings on sex determinates of house flies
Penn researcher Virginia M.Y. Lee, Ph.D., receives $3 million breakthrough prize
Award recognizes Lee’s work studying underlying mechanisms of neurodegenerative diseases
Kīlauea lava fuels phytoplankton bloom off Hawai’i Island
When Kīlauea Volcano erupted in 2018, it injected millions of cubic feet of molten lava into the nutrient-poor waters off the Big Island of Hawai’i. The lava-impacted seawater contained high concentrations of nutrients that stimulated phytoplankton growth, resulting in an…
Diversity of Plasmodium falciparum across Sub-Saharan Africa
SILVER SPRING, Md. – Scientists from the Walter Reed Army Institute of Research joined a network of African scientists, the Plasmodium Diversity Network Africa, and Wellcome Trust Sanger Institute to publish a groundbreaking study about the genetic diversity of the…
A molecular ‘atlas’ of animal development
Researchers from the University of Pennsylvania provide a molecular map of every cell in a developin
Breakdown of spawning synchrony silently threatens coral survival in red sea reefs
Changes to the environmental conditions that underpin the reproductive success of some corals may be causing their highly synchronized mass-spawning strategy to break down, a new study finds. This desynchronization – a previously unnoticed threat – could drive aging coral…
Scientists who raced to study Kilauea’s lava as it fueled rare phytoplankton bloom find surprise
Results from a rapid-response oceanographic expedition in the North Pacific reveal a surprise about how lava from the K?lauea Volcano, which erupted on the island of Hawai’i during the summer of 2018, triggered a vast phytoplankton bloom. The study –…
Breakdown in coral spawning places species at risk of extinction
Synchronized coral spawning has become erratic, endangering the long-term survival of coral species,
First ancient DNA from Indus Valley civilization links its people to modern South Asians
Researchers have successfully sequenced the first genome of an individual from the Harappan civilization, also called the Indus Valley Civilization (IVC). The DNA, which belongs to an individual who lived four to five millennia ago, suggests that modern people in…
Resistance can spread even without the use of antibiotics
Bacteria are becoming increasingly resistant to common antibiotics. Often, resistance is mediated by resistance genes, which can simply jump from one bacterial population to the next. It’s a common assumption that the resistance genes spread primarily when antibiotics are used,…
Horwitz Prize awarded for work on critical cancer pathway
Columbia University will award the 2019 Louisa Gross Horwitz Prize to three scientists: Lewis C. Cantley, Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA, David M. Sabatini, Massachusetts Institute of Technology, Cambridge, Massachusetts, and Howard Hughes…
Climate change could bring short-term gain, long-term pain for loggerhead turtles
TALLAHASSEE, Fla. — An overwhelming scientific consensus affirms that for thousands of species across the globe, climate change is an immediate and existential threat. For the loggerhead turtle, whose vast range extends from the chilly shores of Newfoundland to the…
Novel study reveals presence of fungal DNA in the fetal human gut
A recent human study published in The FASEB Journal discovered the presence of fungal communities in the fetal gut. The study marks the first of its kind to observe fungal DNA in this developmental setting. To conduct the experiment, researchers…
MouseLight project maps 1,000 neurons (and counting) in the mouse brain
Scientists are batting a thousand in a project to reconstruct the mouse brain’s wiring diagram. Researchers at the Howard Hughes Medical Institute’s Janelia Research Campus have now carefully unraveled a tangle of more than 1,000 neurons, tracing each cell’s branching…
New method for imaging biological molecules
Researchers at Karolinska Institutet in Sweden have, together with colleagues from Aalto University in Finland, developed a new method for creating images of molecules in cells or tissue samples. The method is based on the use of DNA snippets and…
A new duck-billed dinosaur, Kamuysaurus japonicus, identified
The dinosaur, whose nearly complete skeleton was unearthed from 72 million year old marine deposits in Mukawa Town in northern Japan, belongs to a new genus and species of a herbivorous hadrosaurid dinosaur, according to the study published in Scientific…
Innovative technique for labeling and mapping inhibitory neurons reveals diverse tuning profile
Researchers at the Max Planck Florida Institute for Neuroscience uncovered a diverse palette of inhi
The argument for sexual selection in bacteria
The evolutionary pressure to pass on DNA can produce behavior that otherwise makes no sense in a struggle to survive. Rams bash heads in fights over females; peacocks grow elaborate tail feathers that attract mates and predators alike. Sexual selection…
Potential vaccine treats and prevents deadly streptococcal toxic shock
A new vaccine developed by Griffith University Institute for Glycomics researchers has the potential to treat and prevent toxic shock caused by invasive streptococcal disease, which kills more than 160,000 people every year. “Streptococcal toxic shock syndrome is an acute…
NIH, Cincinnati Children’s scientists develop possible strategy for cancer drug resistance
Two-pronged approach stymies AML escape plan, could have applications to many cancers
New insight into motor neuron death mechanisms could be a step toward ALS treatment
CORVALLIS, Ore. – Researchers at Oregon State University have made an important advance toward understanding why certain cells in the nervous system are prone to breaking down and dying, which is what happens in patients with ALS and other neurodegenerative…
Mathematical model provides new support for environmental taxes
Taxes that incentivize environmentally friendly practices could promote green development
Squirrels listen in to birds’ conversations as signal of safety
Hearing casual chatter of birds after predator call reassures squirrels to come off high alert
Livestock disease risk tied to herd management style
A new study provides an updated picture of the prevalence of the sheep and goat plague virus (PPRV), a widespread and often fatal disease that threatens 80 percent of the world’s sheep and goats, in northern Tanzania. According to the…
Texas Biomed hires new primate center researcher
Professor studies the impact of cannabinoids on HIV infection and inflammation
Why transporters really matter for cell factories
Scientists discover the secret behind some protein transporters’ superiority
UTEP School of Pharmacy awarded NIH grant to study thirdhand smoke
Researchers at The University of Texas at El Paso’s School of Pharmacy have been awarded $1.8 million from the National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to study the effects of thirdhand smoke…
New model predicts Painted Lady butterfly migrations based on breeding sites data
Institute of Evolutionary Biology press release
Brain circuit connects feeding and mood in response to stress
Many people have experienced stressful situations that trigger a particular mood and also change certain feelings toward food. An international team led by researchers at Baylor College of Medicine looked into the possibility of crosstalk between eating and mood and…
Scientists to use advances in 3D imaging to predict effects of rising CO2 levels on crops
ST. LOUIS, MO, September 4, 2019 – Carbon dioxide (CO2) levels are higher than at any point in the past 800,000 years and in 2017, the global average amount of CO2 hit a new record: 405 parts per million, according…
Genome mining reveals novel production pathway for promising malaria treatment
Microbes are well-known among biologists as master engineers of useful small molecules, and there are many tricks of their trade. When researchers at the University of Illinois took a closer look at how a known microbe makes a known so-called…
New study confirms the long-term benefits of a low-fat diet
Findings in Journal of Nutrition show positive outcomes for cancer and other diseases in women
New viruses discovered in endangered wild Pacific salmon populations
Three new viruses — including one from a group of viruses never before shown to infect fish — have
Denisovan finger bone more closely resembles modern human digits than Neanderthals
Morphology of the denisovan phalanx closer to modern humans than to Neanderthals