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UrduProliferation and differentiation of intestinal stem cell (ISC) to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation. However, when this disordered proliferation continue
Tag: Microenvironment
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
NEWS STORIES IN THIS ISSUE:
– Study Says Failure to Rid Amyloid Beta Protein from Brain May Lead to Alzheimer’s Disease
– Johns Hopkins Medicine Team Discovers Novel Mediator of Once Mysterious Chronic Itch – Study Suggests Molecular Changes in Tissue Microenvironment May Promote Colorectal Cancer
– Researchers ID Anti-Inflammatory Proteins as Therapy Targets for Nasal and Sinus Problem
– Johns Hopkins Children’s Center Receives NIH Award to Study Dangerous Pediatric Disease
Using Stimuli-Responsive Biomaterials to Understand Heart Development, Disease
The heart cannot regenerate new tissue, because cardiomyocytes, or heart muscle cells, do not divide after birth. However, researchers have now developed a shape memory polymer to grow cardiomyocytes. Raising the material’s temperature turned the polymer’s flat surface into nanowrinkles, which promoted cardiomyocyte alignment. The research is part of the growing field of mechanobiology, which investigates how physical forces between cells and changes in their mechanical properties contribute to development, cell differentiation, physiology, and disease.
Scientists Use Geometry to Track Cell Migrations
A team of physicists and biologists investigate the effect that the geometry of the biological environment has on cellular movement. Their findings are published in the journal Science.