A study led by researchers at UT Southwestern Medical Center reveals significant disparities across the country in the use of immunotherapy for patients with advanced kidney and bladder cancers.
Tag: immunotherapies
Study Uncovers At Least One Cause of Roadblocks to Cancer Immunotherapy
A study led by Yale scientists, published April 25 in the journal Science Immunology, investigated the potential causes associated with T cell exclusion using a genome-wide screen of more than 1,000 human proteins.
Researchers Characterize the Immune Landscape in Cancer
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February 14 online issue of Cell. Utilizing data from more than 1,000 tumors across 10 different cancers, the study is the first to integrate DNA, RNA, and proteomics (the study of proteins), revealing the complex interplay of immune cells in tumors. The data came from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), a program under the National Cancer Institute.
Cancer cells with thicker glycocalyx barrier are better at evading immune cells
Researchers examined the material properties of a thin surface barrier called the glycocalyx with unprecedented resolution, revealing information that could help improve current cell-based cancer immunotherapies.
Older Patients Benefit from Cancer Immunotherapies
A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.
UCLA researchers’ efforts to combat melanoma gets $13M boost from NIH
UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.
Novel label-free imaging technique brings out the inner light within T cells
A new imaging method developed by the Skala lab uses the natural autofluorescence within cells to assess T cell activity. The technique could help assess T cell involvement in immunotherapies.
Can the flu shot help fight cancer?
Physicians and scientists at Rush University Medical Center have found that injecting tumors with influenza vaccines, including some FDA-approved seasonal flu shots, turns cold tumors to hot, a discovery that could lead to an immunotherapy to treat cancer. The study results were published December 30th in the Proceedings of the National Academy of Sciences.
To kill tumors, activate this elite group of T cells
LJI’s new understanding of killer T cells inspires clinical studies of potential immunotherapies LA JOLLA, CA – Immunotherapies hold promise as a way to prompt a patient’s own immune system to fight cancer cells. Yet immunotherapies only work in about…